Urine Analysis and Biochemistry Quiz

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Questions and Answers

Ketone bodies can be detected in urine only during severe dehydration.

False (B)

Bilirubin in urine indicates the presence of liver disease or biliary obstruction.

True (A)

Urobilinogen levels decrease during excessive hemolysis.

False (B)

Bilirubinuria is not generally found in cases of hemolytic jaundice.

<p>True (A)</p> Signup and view all the answers

The color of the ketone test ranges from purple to buff-pink.

<p>False (B)</p> Signup and view all the answers

Glucose is a component tested for using Multistix strips in urine analysis.

<p>True (A)</p> Signup and view all the answers

Urethra links the kidney to the bladder.

<p>False (B)</p> Signup and view all the answers

The reactions from urine tests can only be read visually without any tools.

<p>False (B)</p> Signup and view all the answers

The urine analysis is regarded as quantitative.

<p>False (B)</p> Signup and view all the answers

The bladder serves as a storehouse for urine.

<p>True (A)</p> Signup and view all the answers

Protein is not tested for using Multistix strips.

<p>False (B)</p> Signup and view all the answers

Renal function includes regulating the composition and volume of body fluids.

<p>True (A)</p> Signup and view all the answers

Urine is composed of approximately 90% water.

<p>False (B)</p> Signup and view all the answers

Specific gravity measures the density of urine relative to the density of air.

<p>False (B)</p> Signup and view all the answers

The presence of protein in urine usually indicates normal renal concentration.

<p>False (B)</p> Signup and view all the answers

Urinalysis can be used for routine medical examinations and monitoring diseases.

<p>True (A)</p> Signup and view all the answers

A specific gravity (sg) of 1.025 typically indicates normal renal concentration.

<p>True (A)</p> Signup and view all the answers

Specific gravity is not relevant in assessing the degree of glucosuria.

<p>False (B)</p> Signup and view all the answers

Urine chemistry strip tests do not include measurement of pH.

<p>False (B)</p> Signup and view all the answers

The preferable sample for measuring specific gravity should be urine that has been in the bladder for at least 2 hours.

<p>False (B)</p> Signup and view all the answers

Leucocytes are one of the components tested in standard urine chemistry strip tests.

<p>True (A)</p> Signup and view all the answers

Proteinuria is a condition that is only associated with diabetes mellitus.

<p>False (B)</p> Signup and view all the answers

Haematuria indicates the presence of blood in urine.

<p>True (A)</p> Signup and view all the answers

The renal threshold for glucose is approximately 5 mmol/l.

<p>False (B)</p> Signup and view all the answers

Jaundice can be caused by conditions such as Schistosomiasis.

<p>True (A)</p> Signup and view all the answers

Contaminated urine can lead to false negative reactions in glucometry tests.

<p>False (B)</p> Signup and view all the answers

Ketone bodies are produced during fat metabolism when glucose is absent.

<p>True (A)</p> Signup and view all the answers

Eclampsia is defined by low blood pressure and kidney function.

<p>False (B)</p> Signup and view all the answers

False positive reactions in urine tests may occur due to disinfectants containing ammonium compounds.

<p>True (A)</p> Signup and view all the answers

Sickle cell disease is associated with haemoglobinuria.

<p>True (A)</p> Signup and view all the answers

The enzyme glucose oxidase catalyzes the transformation of glucose into acetone.

<p>False (B)</p> Signup and view all the answers

Low urine specific gravity indicates an inability of the kidney to concentrate urine with values ranging from 1.001 to 1.003.

<p>True (A)</p> Signup and view all the answers

High urine specific gravity can result from excessive water loss and can reach values as high as 1.050 in cases of diabetes mellitus.

<p>True (A)</p> Signup and view all the answers

The pH of normal freshly passed urine is typically around 8.0.

<p>False (B)</p> Signup and view all the answers

Methyl red and bromthymol blue are indicators used in urine pH testing that provide colors from orange to blue.

<p>True (A)</p> Signup and view all the answers

Proximal tubular dysfunction leads to an elevation of hydrogen ions in the urine.

<p>False (B)</p> Signup and view all the answers

Alkaline urine causes the precipitation of uric acid.

<p>False (B)</p> Signup and view all the answers

Diet and renal tubular function are factors that influence urine pH.

<p>True (A)</p> Signup and view all the answers

Diabetes insipidus can lead to the high urine specific gravity of 1.050.

<p>False (B)</p> Signup and view all the answers

Renal disease can be diagnosed using urine pH as an important screening test.

<p>True (A)</p> Signup and view all the answers

The balance of acids and bases in the body has no effect on urine pH.

<p>False (B)</p> Signup and view all the answers

Flashcards

Macroscopic Examination of Urine

The color and appearance of urine can offer clues about a person's health. For example, dark yellow urine might indicate dehydration, while cloudy urine could suggest an infection.

Multistix 10 SG /COMBI-10 Test Strip

The Multistix 10 SG /COMBI-10 test strip is a common tool that helps measure 10 different components in urine, revealing valuable information about your health.

Urine Chemistry Tests

The Multistix test strip is used to measure various components in your urine, like glucose, bilirubin, ketones, and more.

Diagnostic Indications of Urine Chemistry Tests

Urine chemistry tests provide insights into your health based on the results of analyzing your urine components, aiding in diagnosis.

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Renal Structure and Functions

The kidneys, ureters, bladder, and urethra work together to filter waste from your body and produce urine.

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Urine in Diseased Conditions

In diseased conditions, the kidneys may not function correctly, causing substances that should be excreted or reabsorbed to appear in the urine in abnormal amounts.

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What is Urine?

Urine is a liquid waste product created by the kidneys through filtering blood and removing waste products.

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Urine

A waste product of the body composed of water, electrolytes like sodium, potassium, magnesium, chloride, bicarbonates and waste products of metabolism like urea, uric acid and creatinine.

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Urine production

The process of filtering blood in the kidneys and producing urine. It involves three steps: glomerular filtration, tubular reabsorption and tubular secretion.

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Urinalysis

A set of tests performed on urine to analyze its chemical composition and microscopic properties. It helps to diagnose, understand the cause and monitor progress of diseases.

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Urine chemistry strip test

A urine test that uses a strip with different chemical pads to detect various substances like protein, glucose, ketones, blood, etc.

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Specific Gravity (SG)

A measure of urine density compared to water. It indicates the concentration of dissolved substances like urea, sodium and glucose in urine.

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Specific gravity and kidney function

SG is a measure of urine concentration as a marker of kidney function. A normal SG usually suggests good kidney function, while a low SG may indicate kidney problems.

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Urine pH

A measure of acidity or alkalinity of urine. It can help diagnose kidney problems and infections.

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Nitrite test

A test for the presence of bacteria in urine, which can indicate a urinary tract infection (UTI).

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Leukocyte test

Detects the presence of white blood cells (leukocytes) in urine, which can be a sign of infection or inflammation.

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Urine Specific Gravity

A measurement of the concentration of dissolved substances in urine, indicating how well the kidneys are concentrating urine.

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Low Urine Specific Gravity

A urine specific gravity below 1.003, indicating the inability of the kidneys to concentrate urine.

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High Urine Specific Gravity

A urine specific gravity above 1.030, indicating the kidneys are concentrating urine too much.

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Normal Urine pH

The normal range of urine pH, which can vary depending on factors like diet and overall health.

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Factors Affecting Urine pH

The pH of urine can fluctuate based on diet, acid-base balance, and renal function.

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Abnormal Urine pH

An indicator of a problem with the kidneys' ability to reabsorb bicarbonate and secrete hydrogen ions.

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Measuring Urine Specific Gravity

The process of measuring the concentration of dissolved substances in urine to assess kidney function.

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Diagnostic Uses of Urine Tests

Urine tests can help diagnose a range of conditions, from kidney disease and respiratory problems to metabolic disorders.

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What are ketone bodies?

A substance produced by the body when there is not enough insulin to help glucose enter cells. Ketone bodies are used by the body when blood glucose levels are low.

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What is ketoacidosis?

A condition characterized by high levels of ketones in the blood, usually due to lack of insulin or starvation. It can lead to serious health issues.

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What is bilirubin?

A yellow pigment produced when red blood cells break down. It's usually processed by the liver but can build up in the blood and urine in certain conditions.

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What is urobilinogen?

A substance that originates from the breakdown of bilirubin by bacteria in the intestines. It's normally reabsorbed into the body and excreted in the urine.

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What is a urine ketone test?

A urine test that detects the presence of ketones in the urine. It is used to diagnose conditions like ketoacidosis, diabetes, and starvation.

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Glucosuria

A condition characterized by the presence of high glucose levels in the urine, usually due to uncontrolled diabetes, but can occur in other situations like pregnancy.

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Proteinuria

A type of protein in the urine, often associated with kidney damage, infections, or pregnancy-related complications like preeclampsia.

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Haematuria/Haemoglobinuria

The presence of blood or blood components in the urine, often indicating kidney problems, infection, or trauma.

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Ketone Bodies in Urine

A condition marked by high ketone bodies in the urine, typically due to the body burning fat for energy instead of glucose, often associated with poorly managed diabetes.

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Jaundice

A condition characterized by yellowing of the skin and whites of the eyes, usually caused by a buildup of bilirubin in the body.

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Hyperthyroidism

A condition where the thyroid gland produces too much thyroid hormone, leading to increased metabolism, weight loss, and other symptoms.

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Febrile illnesses

An increase in the body's temperature due to an infection, often accompanied by other symptoms like sweating and chills.

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Severe UTI

A severe urinary tract infection (UTI) that spreads to the kidneys, potentially leading to serious complications.

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Preeclampsia

A serious condition characterized by high blood pressure and proteinuria, often affecting the kidneys and other organs, commonly seen in pregnant women.

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Nephrotic syndrome

A condition characterized by a large amount of protein in the urine, often caused by kidney damage or other underlying health issues.

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Study Notes

Diagnostic Indications of Urinalysis

  • Urinalysis is a series of tests on urine (chemistry and microscopy) to determine the nature, causes, and prognosis of diseases.
  • Urinalysis has applications in routine medical examinations, screening and preventive medicine, and monitoring diseases and their treatments.

Macroscopic Examination

  • Examination of urine color and appearance are part of urinalysis.
  • Urine color and appearance testing uses commercial disposable test strips, like Multistix 10 SG/COMBI-10.

Chemical Examination of Urine Using Test Strips

  • Tests for glucose, bilirubin, ketones, specific gravity, blood, pH, protein, urobilinogen, nitrite, and leukocyte esterase.
  • Results from test strips are considered semi-quantitative.
  • Proper handling of urine samples and use of the correct test strips are crucial.

Urine Collection and Preparation for Testing

  • Urine specimens are collected in clean, dry containers.
  • The Multistix strip is immersed in the urine sample, covering all areas and then run against the rim of the container to remove excess urine.
  • The strip is held horizontally and read visually or automatically.
  • Results are compared to a chart and recorded. The strip is then discarded.

Diagnostic Indications of Urine Chemistry Tests

  • Diagnostic: A method for finding physical or mental problems a person has.
  • Indication: A sign, or a condition that something will happen is true or exists.
  • Diagnostic Indication: A determination of a condition based on urine chemistry test results.

Renal Structure and Functions

  • Kidney (Nephron and Tubules): Regulates body fluid volume and composition, maintains homeostasis.
  • Ureter: Connects the kidney to the bladder.
  • Bladder: Stores urine.
  • Urethra: Connects the bladder to the outside of the body.
  • Substances normally reabsorbed or excreted in small amounts may appear in large amounts in the urine during disease.
  • Substances normally removed might be reabsorbed.

Nephron Structure and Function

  • Proximal Convoluted Tubule: Reabsorbs water, ions, and nutrients.
  • Renal Corpuscle: Produces filtrate.
  • Loop of Henle: Reabsorbs water and solutes. - Distal Convoluted Tubule: Regulates water and electrolyte balance.
  • Collecting Duct: Concentrates urine.

What is Urine?

  • Urine is a waste product of the body, composed primarily of water (about 95%).
  • It also contains electrolytes (sodium, potassium, magnesium, chloride, bicarbonate) and metabolic wastes (urea, uric acid, creatinine).
  • Urine production and composition depend on glomerular filtration, tubular reabsorption, and tubular secretion.

Urine pH

  • Normal freshly voided urine is slightly acidic (pH 6.0), but can range from 4.5 to 8.0.
  • Urine pH depends on acid–base balance, water balance, diet, and renal tubular function.
  • Urine pH can be elevated in conditions associated with high acid loss (e.g., severe vomiting), or acidosis, while low pH can be seen with conditions like severe diarrheal illness.

Urine Specific Gravity (SG)

  • Specific gravity is a measurement of urine density compared to water.
  • It's an indicator of the amount of dissolved solids (solutes) in urine, reflecting hydration status and concentrating ability of the kidneys.
  • Normal values are typically between 1.003 and 1.030
  • Low specific gravity may indicate a concentrating defect, while high SG (>1.025) suggests urine is very concentrated

Microscopic Examination of Urine

  • Microscopic examination is a standard practice in many laboratories, even if chemical tests are normal.
  • The examination focuses on identifying formed elements (casts, cells, bacteria, yeast, parasites, and crystals) in the centrifuged urine sediment.
  • Specific microscopic techniques and procedures exist for detailed analysis.

Urine Testing Overview

  • Various urine components like glucose, proteins, ketones, bile pigments, formed elements,and crystals are commonly examined using both macroscopic and microscopic analysis.
  • Each component has specific significance in terms of disease diagnosis or detection of other issues.

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