Podcast
Questions and Answers
The alteration of _____________ pH is important in pharmacology.
The alteration of _____________ pH is important in pharmacology.
urinary
Drugs for _____________ are used to increase drug elimination in overdose.
Drugs for _____________ are used to increase drug elimination in overdose.
alkalinization
In acidic pH, an _____________ drug becomes ionized.
In acidic pH, an _____________ drug becomes ionized.
acidic
Alkaline diuresis is used to remove _____________ drugs from the body.
Alkaline diuresis is used to remove _____________ drugs from the body.
Phenobarbitone is an example of a drug that undergoes _____________ diuresis.
Phenobarbitone is an example of a drug that undergoes _____________ diuresis.
Increasing the pH of urine can increase the efficacy of _____________ in the urine.
Increasing the pH of urine can increase the efficacy of _____________ in the urine.
Shimaa Mohamed Elkholy is a professor in the _____________ department.
Shimaa Mohamed Elkholy is a professor in the _____________ department.
Drugs for _____________ are used to increase the elimination of basic drugs from the body.
Drugs for _____________ are used to increase the elimination of basic drugs from the body.
Aminoglycosides are classified as ________ antibiotics.
Aminoglycosides are classified as ________ antibiotics.
To discourage the growth of certain urinary pathogen, ________ of urine is necessary.
To discourage the growth of certain urinary pathogen, ________ of urine is necessary.
Symptomatic relief of cystitis can be achieved through ________ of urine.
Symptomatic relief of cystitis can be achieved through ________ of urine.
Sulfonamide is an example of a drug that requires ________ of urine.
Sulfonamide is an example of a drug that requires ________ of urine.
To reduce stone formation, ________ of urine is necessary for urate stones.
To reduce stone formation, ________ of urine is necessary for urate stones.
Sodium bicarbonate is a drug used for ________ of urine.
Sodium bicarbonate is a drug used for ________ of urine.
Acetazolamide is a drug used for ________ of urine.
Acetazolamide is a drug used for ________ of urine.
Acidification of urine is necessary for ________ stones.
Acidification of urine is necessary for ________ stones.
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Study Notes
Importance of Urinary pH
- Alkaline or acidic diuresis can increase drug elimination in overdose cases
- Acidic diuresis is used for acidic drugs, while alkaline diuresis is used for basic drugs
Examples of Drugs
- Acidic drugs: phenobarbitone, salicylate, aspirin, pethidine
- Basic drugs: amphetamines, ephedrine
Importance of Urinary pH in Antimicrobial Efficacy
- Alkaline urine increases the efficacy of antimicrobials such as aminoglycosides, tetracycline, erythromycin, penicillins, nitrofurantoin, and cephalosporins
Importance of Urinary pH in Discouraging Growth of Urinary Pathogens
- Alkaline urine discourages the growth of E. coli
Importance of Urinary pH in Symptomatic Relief of Cystitis
- Alkaline urine provides symptomatic relief of cystitis
Importance of Urinary pH in Preventing Crystalluria
- Alkaline urine prevents crystalluria of sulfonamide
- Acidic urine prevents crystalluria of urate
- Alkaline urine prevents crystalluria of phosphate
Drugs for Alkalinization
- Sodium bicarbonate
- Sodium lactate
- Sodium or potassium citrate
- Acetazolamide
Drugs for Acidification
- (No specific drugs mentioned)
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