Podcast
Questions and Answers
What is a primary objective of surgery in managing re-bleeding?
What is a primary objective of surgery in managing re-bleeding?
- To completely eliminate all symptoms
- To achieve curative goals and reduce acid component (correct)
- To avoid the use of medication
- To perform a diagnostic procedure
Which scoring systems are used for risk stratification?
Which scoring systems are used for risk stratification?
- Rockwell Score and Glasgow Score
- Rockall Score and CURB-65
- Rockall Score and APACHE II Score
- Rockall Score and Blatchford Scoring System (correct)
Which of the following is NOT a risk factor to consider during risk stratification?
Which of the following is NOT a risk factor to consider during risk stratification?
- Type of previous surgeries (correct)
- Shock due to tachycardia
- Major co-morbid conditions
- Age of the patient
What is the initial treatment for H. Pylori infection?
What is the initial treatment for H. Pylori infection?
What is a possible complication when using CT for mesenteric angiography?
What is a possible complication when using CT for mesenteric angiography?
If initial endoscopic hemostasis fails, what is the next recommended intervention?
If initial endoscopic hemostasis fails, what is the next recommended intervention?
What is the recommended duration for administering a PPI after treating H. Pylori infection?
What is the recommended duration for administering a PPI after treating H. Pylori infection?
Which of the following is an indication of stigmata of recent hemorrhage during physical examination?
Which of the following is an indication of stigmata of recent hemorrhage during physical examination?
What is a Curling ulcer?
What is a Curling ulcer?
Which of the following is associated with a Mallory-Weiss tear?
Which of the following is associated with a Mallory-Weiss tear?
What type of bleeding is most commonly associated with a Cushing’s ulcer?
What type of bleeding is most commonly associated with a Cushing’s ulcer?
Dieulafoy’s disease is characterized by which feature?
Dieulafoy’s disease is characterized by which feature?
What are some signs of anemia that can be observed?
What are some signs of anemia that can be observed?
Which condition can lead to anemia signs such as pallor of the palmar creases?
Which condition can lead to anemia signs such as pallor of the palmar creases?
In which patient demographic is Dieulafoy’s disease more commonly found?
In which patient demographic is Dieulafoy’s disease more commonly found?
What is the primary cause of a Cushing's ulcer?
What is the primary cause of a Cushing's ulcer?
What is the primary purpose of conducting a CT scan in the context of staging cancer?
What is the primary purpose of conducting a CT scan in the context of staging cancer?
Which imaging technique combines the spatial resolution of CT with the contrast resolution of PET?
Which imaging technique combines the spatial resolution of CT with the contrast resolution of PET?
In patients believed to have local-regional disease, what percentage of cases does routine laparoscopy detect small volume peritoneal and liver metastases?
In patients believed to have local-regional disease, what percentage of cases does routine laparoscopy detect small volume peritoneal and liver metastases?
Which stage indicates a Tis classification in cancer staging?
Which stage indicates a Tis classification in cancer staging?
What laboratory marker is considered poor nutritional status when its level falls below 35?
What laboratory marker is considered poor nutritional status when its level falls below 35?
Which staging classification reflects the presence of both nodal involvement and distant metastasis?
Which staging classification reflects the presence of both nodal involvement and distant metastasis?
Which of the following tests is primarily used to assess hemoglobin levels?
Which of the following tests is primarily used to assess hemoglobin levels?
What limitation does a CT scan have regarding nodal involvement assessment?
What limitation does a CT scan have regarding nodal involvement assessment?
What symptoms are associated with intermediate stage gastric carcinoma?
What symptoms are associated with intermediate stage gastric carcinoma?
Which of the following complications are indicative of symptomatic anemia?
Which of the following complications are indicative of symptomatic anemia?
In the management of a patient with massive hematemesis, what is the recommended initial fluid resuscitation?
In the management of a patient with massive hematemesis, what is the recommended initial fluid resuscitation?
What is a potential consequence of fluid overload during resuscitation?
What is a potential consequence of fluid overload during resuscitation?
Which class of blood loss is characterized by a narrowed pulse pressure and resting tachycardia?
Which class of blood loss is characterized by a narrowed pulse pressure and resting tachycardia?
What should be suspected in a patient with bleeding and no history of alcohol abuse or NSAID use?
What should be suspected in a patient with bleeding and no history of alcohol abuse or NSAID use?
What condition predisposes older patients (>60) to hypoxemia?
What condition predisposes older patients (>60) to hypoxemia?
In which stage of gastric carcinoma is a patient likely to experience loss of appetite and obstructive jaundice?
In which stage of gastric carcinoma is a patient likely to experience loss of appetite and obstructive jaundice?
What is the primary symptom of haemoptysis?
What is the primary symptom of haemoptysis?
How does melena differ from iron stool when mixed with water?
How does melena differ from iron stool when mixed with water?
What characteristic of the vomitus indicates hematemesis?
What characteristic of the vomitus indicates hematemesis?
What crucial detail should be assessed in a patient with a history of variceal bleeding?
What crucial detail should be assessed in a patient with a history of variceal bleeding?
A brisk upper GI bleed can cause what type of bleeding?
A brisk upper GI bleed can cause what type of bleeding?
What factor is least likely to influence the color of vomited blood in hematemesis?
What factor is least likely to influence the color of vomited blood in hematemesis?
What is the expected appearance of expectorated blood in a case of haemoptysis?
What is the expected appearance of expectorated blood in a case of haemoptysis?
Which sign would suggest that the vomited blood has been altered by gastric acid?
Which sign would suggest that the vomited blood has been altered by gastric acid?
What is a common site for lymphatic spread from gastric cancer?
What is a common site for lymphatic spread from gastric cancer?
Which type of gastric cancer accounts for the largest percentage of cases?
Which type of gastric cancer accounts for the largest percentage of cases?
What mechanism is primarily associated with the spread of gastric neuroendocrine tumors?
What mechanism is primarily associated with the spread of gastric neuroendocrine tumors?
Which of the following is NOT a potential site of haematogenous spread in gastric cancer?
Which of the following is NOT a potential site of haematogenous spread in gastric cancer?
Which histological type is categorized as a non-adenocarcinoma type of gastric cancer?
Which histological type is categorized as a non-adenocarcinoma type of gastric cancer?
What is a defining feature of gastrointestinal stromal tumours (GISTs)?
What is a defining feature of gastrointestinal stromal tumours (GISTs)?
Which artery's branches are implicated in the lymphatic spread of gastric cancer?
Which artery's branches are implicated in the lymphatic spread of gastric cancer?
What condition is associated with hypergastrinemia in gastric cancer development?
What condition is associated with hypergastrinemia in gastric cancer development?
Flashcards
Hematemesis
Hematemesis
Vomiting of blood from the upper gastrointestinal tract (proximal to the ligament of Treitz, at the D-J junction). The color depends on contact time with stomach acid, ranging from red to brown.
Haemoptysis
Haemoptysis
Bloody expectoration from the larynx, trachea, bronchi, and lungs. Patients describe feeling something in their throat followed by the sudden expulsion of often frothy, bright red blood.
Melena
Melena
Dark, tarry stools that are black due to the presence of digested blood. Occurs when blood has been in the digestive tract for a while and has been acted upon by stomach acid.
Iron stool
Iron stool
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Frank PR bleeding
Frank PR bleeding
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Determining etiology of GI bleed
Determining etiology of GI bleed
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Differential diagnosis for GI bleed
Differential diagnosis for GI bleed
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Nature of bleeding
Nature of bleeding
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Curling Ulcer
Curling Ulcer
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Cushing's Ulcer
Cushing's Ulcer
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Mallory-Weiss Tear
Mallory-Weiss Tear
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Dieulafoy's Disease
Dieulafoy's Disease
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Variceal Bleed
Variceal Bleed
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Non-Variceal Bleed
Non-Variceal Bleed
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Signs of Anemia
Signs of Anemia
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Looking for Complications
Looking for Complications
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Management of GI bleed
Management of GI bleed
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Comorbidities in GI bleeding
Comorbidities in GI bleeding
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Non-variceal Upper GI Bleed
Non-variceal Upper GI Bleed
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Rockall Score
Rockall Score
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Blatchford Scoring System
Blatchford Scoring System
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Endoscopic Haemostasis
Endoscopic Haemostasis
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Surgery or Radiological Intervention
Surgery or Radiological Intervention
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CT Mesenteric Angiogram
CT Mesenteric Angiogram
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Mesenteric Angiogram KIV Embolization
Mesenteric Angiogram KIV Embolization
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Stigmata of Recent Haemorrhage
Stigmata of Recent Haemorrhage
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PPI (Proton Pump Inhibitor)
PPI (Proton Pump Inhibitor)
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Stage M1
Stage M1
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PET Scan
PET Scan
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Laparoscopic Staging
Laparoscopic Staging
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TNM Staging System
TNM Staging System
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Endoscopy
Endoscopy
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Upper GI Endoscopy
Upper GI Endoscopy
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Variceal Band Ligation
Variceal Band Ligation
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Octreotide
Octreotide
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Gastrointestinal Stromal Tumors (GISTs)
Gastrointestinal Stromal Tumors (GISTs)
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Lymphatic Spread of Gastric Cancer
Lymphatic Spread of Gastric Cancer
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Haematogenous Spread of Gastric Cancer
Haematogenous Spread of Gastric Cancer
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Spread to Peri-gastric and Para-aortic Lymph Nodes
Spread to Peri-gastric and Para-aortic Lymph Nodes
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Virchow's Node
Virchow's Node
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Hepatosplenomegaly with Ascites and Jaundice
Hepatosplenomegaly with Ascites and Jaundice
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Hypergastrinemia
Hypergastrinemia
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H. Pylori and Trisomy 3 in Gastric Cancer
H. Pylori and Trisomy 3 in Gastric Cancer
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Study Notes
Upper Gastrointestinal Bleeding (UGIT) Causes
- Variceal Bleed: Gastro-oesophageal varices (30%) are a common cause of upper GI bleeding.
- Non-variceal Bleed:
- Mallory-Weiss tear (10%)
- Peptic ulcer disease (bleeding peptic ulcer) (50%)
- Gastritis, gastric erosions, duodenitis
- Gastric malignancy (10%)
- Dieulafoy lesion - large tortuous arteriole in the stomach
- Aorto-enteric fistula (5%)
- Bleeding from other sources: Haemoptysis, nasopharyngeal bleeding
History (Stable Patient)
- Nature of bleeding:
- Confirm hematemesis (vomiting blood) or rule out haemoptysis (coughing up blood).
- Haemoptysis: Bloody expectoration from the lungs.
- Hematemesis (blood or coffee-ground emesis): Vomiting of blood. Vomit colour depends on stomach acid contact time (fresh red = severe, coffee grounds = less severe).
- Melena (black tarry stool): Passage of altered blood from the upper GI tract (proximal to Treitz ligament).
- Fresh versus Stale Melena: Fresh melena is jet black and tarry, often almost liquid-like; stale melena is black-grey and dull, and sometimes mixed with normal stool.
Factors predictive of UBGIT
- Patient-reported history of melena (LR: 5.1-5.9)
- Melenic stool on examination (LR: 25)
- Blood or coffee grounds detected during NG lavage (LR: 9.6)
- Ratio of BUN (Blood Urea Nitrogen) to Serum Cr > 30 (LR: 7.5).
Determining Etiology (variceal vs. non-variceal bleed)
- Previous variceal bleed: ask about banding or OGD (upper endoscopy) screening.
- Chronic liver disease: identify potential risk factors (alcohol, hepatitis B/C).
Physical Examination
- Vital Signs: Assess hemodynamic stability and postural blood pressure. Include any tachycardia.
- Determine Etiology: Check for stigmata of chronic liver disease (i.e. jaundice).
- Look for complications: Signs of anemia (pallor of skin or mucous membranes). Cardiac auscultation, pulse (e.g. rate, strength), and condition of hands. Lung and abdominal examination to exclude peritonism.
Immediate Management
- Resuscitation:
- Airway assessment and management.
- IV access with large-bore cannulae.
- Bloods for investigation: Full blood count (FBC), Urea and electrolytes (U&E), coagulation profile (PT/PTT), Liver function tests (LFT), arterial blood gases (ABGs), lactate levels, ECG, chest x-ray (CXR).
- Initial IV fluid resuscitation: normal saline (0.9% NaCl).
- Closely monitor patient response.
- Adjuncts:
- Blood transfusion strategy (maintain Hb > 7g/dL).
- Platelets if patient on antiplatelets.
- Fresh frozen plasma (FFP) if patient is on anticoagulants or PT/PTT is prolonged.
- NG tube if hematemesis present to prevent aspiration.
- Early medications: IV omeprazole to increase stomach pH and stabilize blood clots. If varices suspected, consider somatostatin/ocreotide, and broad-spectrum antibiotics.
- Monitoring: Shock (HR, BP) and urine output, and patient parameters hourly. Stop NSAIDs, antiplatelets and anticoagulants if any.
Diagnostic Studies
- Acute GI bleed: OGD, blood/bile/no blood, Tagged RBC Scan/Angiography
- OGD to localize and treat.
Subsequent Management
- Risk Stratification: Assess using Rockall score or Blatchford scoring system. Include age and shock status prior to and after OGD.
- Management of re-bleeding: Repeat OGD for haemostasis. Consider surgery if endoscopic procedure fails.
Variceal Bleeding
- Active Variceal Bleed:
- Resuscitate, IV access, airway management.
- Labs (GXM, FBC, U&E, PT/PTT, LFT, ABG, etc.).
- Fluids, blood transfusion if Hb < 7g/dL aiming for > 7g/dL
- IV somatostatin/ocreotide, IV antibiotics, Omeprazole.
- Prophylaxis (Prevention):
- Band ligation and beta-blockers to reduce bleeding risk. This includes long-acting nitrates if beta-blockers contraindicated.
Gastric Cancer
- Epidemiology: 7th/8th most common cancers in males/females. Ethnicity, gender, and genetics are factors.
- Risk Factors: H. pylori infection. Diet (processed foods, smoked, high salt). Smoking, Family history, Alcohol, GERD, previous gastric surgery, etc.
- Classification: Borrmann's classification (polypoid, excavating, ulcerative, diffuse thickening).
- Histological types: Adenocarcinomas (95%) (intestinal/diffuse). Non-adenocarcinomas (5%): (neuroendocrine, lymphoma, GIST).
Investigations
- OGD and biopsies
- Barium meal and follow through
Pathophysiology:
- Active Processes: Gastric acid secretion, pepsin production, inflammation, presence of H. pylori, and prolonged NSAID use.
- Protective Mechanisms: Mucus, bicarbonate secretion, blood flow and cell regeneration.
Treatment (complicated PUD):
- Haemorrhage: Endoscopy [epinephrine injection, thermal, mechanical], pharmacologic (omeprazole), TAE (transcatheter arterial embolization) if needed, surgery.
- Perforation: NBM. IV hydration, antibiotics, NGT with low suction, serial abdominal exam.
- Gastric outlet obstruction: NGT. IV antisecretory agents (e.g., omeprazole), possible endoscopic or surgical interventions (dilation).
- Massive transfusion complications: Fluid overload, immunological complications, infections, and metabolic disturbance.
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