Unveiling the Power of mRNA Vaccines
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Questions and Answers

Which process produces siRNAs that silence complementary sequences?

  • RNA Interference (correct)
  • Gene disruption/knockout
  • Synthetic siRNAs
  • microRNA (miRNA)

What is the main function of synthetic siRNAs?

  • To protect the germline from transposable elements
  • To introduce mutated genes to embryonic stem cells
  • To produce a transient outcome by targeting mRNA (correct)
  • To block post-transcriptional expression of genes

Which method of vaccine production involves making recombinant gene to produce recombinant protein as vaccine?

  • Traditional method (correct)
  • Kariko & Weissman method
  • Bivalent vaccines
  • mRNA vaccines

What is the role of microRNA (miRNA) in gene expression?

<p>To bind to mRNA and prevent the protein from being translated (A)</p> Signup and view all the answers

Which scientists discovered that base-modified mRNA can be used to block activation of inflammatory reactions?

<p>Kariko &amp; Weissman (C)</p> Signup and view all the answers

What is the precursor of siRNA that forms a hairpin loop?

<p>shRNA (C)</p> Signup and view all the answers

Which of the following is an advantage of using lipid nanoparticles for delivering mRNA vaccines?

<p>Both A and B (C)</p> Signup and view all the answers

What is the main function of PIWI-interacting RNA (piRNA)?

<p>To protect genome integrity from transposable elements (B)</p> Signup and view all the answers

Which companies used lipid nanoparticles with PEG in their mRNA vaccines?

<p>Moderna &amp; Pfizer (D)</p> Signup and view all the answers

What enzyme complex binds to siRNA and attaches to the guide strand?

<p>RISC (B)</p> Signup and view all the answers

What is a limitation of mRNA vaccines?

<p>Need for low temperature (C)</p> Signup and view all the answers

What enzyme is part of the RISC and cleaves and degrades mRNA?

<p>Argonaute (B)</p> Signup and view all the answers

Which organisms are commonly used as eukaryotic model organisms for genome editing?

<p>Mus musculus (D)</p> Signup and view all the answers

What is the function of Dicer in RNA interference?

<p>To produce siRNAs from dsRNA (D)</p> Signup and view all the answers

What is the classic way of genome editing that involves changing DNA at a desired position using a PCR-based technique?

<p>Site-directed mutagenesis (C)</p> Signup and view all the answers

Which type of RNA contains the genetic information for protein translation?

<p>mRNA (A)</p> Signup and view all the answers

What is the purpose of cassette mutagenesis in genome editing?

<p>Introduce variety of mutations to a gene of interest (A)</p> Signup and view all the answers

What is the limitation of synthetic siRNAs as a treatment?

<p>They only produce a transient outcome (A)</p> Signup and view all the answers

What is the difference between random and targeted insertion in genome editing using viral vectors?

<p>Targeted insertion can occur anywhere in the genome (D)</p> Signup and view all the answers

What is the purpose of knockout mice in genome editing?

<p>Study genetic diseases and efficacy of treatments (B)</p> Signup and view all the answers

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