term 1 - week9

Questions and Answers

Arrange the following cellular events in the proper order in which they occur in the activation of NFkB pathway 1= IKK complexes phosphorylate IκB proteins 2= IκB ubiquitination and proteasomal degradation 3= NF-κB complexes translocate into the nucleus 4= NF-κB complexes induce target gene expression

1, 2, 3, 4 (correct)

1, 3, 2, 4

2, 3, 1, 4

2, 3, 4, 1

How does NF-κB induce gene expression?

A small, hydrophobic ligand binds to NF-κB, activating it

Phosphorylation of the inhibitor Iκ-B dissociates the complex between it and NF-κB, and allows NF-κB to enter the nucleus and stimulate transcription (correct)

NF-κB is phosphorylated and is then free to enter the nucleus and bind DNA

. NF-κB is a kinase that phosphorylates a transcription factor that binds DNA and promotes protein production.

Activation of NFkB pathway results in the transcription of genes involved in cell survival and inflammation. What prevents this process from occurring in the absence of stimuli?

. Binding of IkBa to NFkB dimer (correct)

Phosphorylation of RelA

Lack of transcription of IkBa

Ubiquitination and proteasomal degradation of NFkB dimer

Ubiquitination is a post-translational modification process, that attaches ubiquitin to a target protein. This process plays an important role in the activation of NFkB pathway. What is ubiquitin?

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term 1 - week9

Questions and Answers

How does NF-κB induce gene expression?

Activation of NFkB pathway results in the transcription of genes involved in cell survival and inflammation. What prevents this process from occurring in the absence of stimuli?

Ubiquitination is a post-translational modification process, that attaches ubiquitin to a target protein. This process plays an important role in the activation of NFkB pathway. What is ubiquitin?

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