Embryology of the Reproductive Systems

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Questions and Answers

When is genetic sex determined?

  • during meiosis I of gametogenesis
  • fertilization (correct)
  • at then end of the embryonic period (GW8)
  • at birth

Which of the following is necessary and sufficient for the production of testes?

  • sperm
  • Y chromosome (correct)
  • X chromosome
  • DHT

What is the role of sex hormones produced by the gonads?

  • Control bone density
  • Regulate neurotransmitter production in the brain
  • Regulate development of secondary sexual characteristics (correct)
  • Aid in digestion

Which condition is characterized by an extra X chromosome in males?

<p>Klinefelter syndrome (D)</p> Signup and view all the answers

How do the hypothalamus and pituitary gland contribute to the endocrine system in relation to sex hormones?

<p>Regulate the production of sex hormones (B)</p> Signup and view all the answers

Which condition results in ovaries developing without functional follicles?

<p>Turner syndrome (A)</p> Signup and view all the answers

What arises from the mesoderm layer during embryonic development and eventually gives rise to the testes or ovaries?

<p>Gonadal ridge (A)</p> Signup and view all the answers

In humans, at what stage of gestation does gonadal development typically occur?

<p>Between weeks 7 and 12 (D)</p> Signup and view all the answers

What leads to the development of testes in males and ovary in females during sexual differentiation?

<p>Presence of SRY gene (B)</p> Signup and view all the answers

How do testes and ovaries develop differently under the influence of the SRY gene?

<p>Testes develop from mesenchyme, ovaries develop from the epithelium (C)</p> Signup and view all the answers

What is the primary role of Mullerian Inhibitory Factor (MIF) in sexual differentiation?

<p>Preventing the regression of Mullerian ducts in males (A)</p> Signup and view all the answers

What happens if there is a disruption in the balance between Mullerian Inhibitory Factor (MIF) and Anti-Mullerian Hormone (AMH)?

<p>Abnormal sexual development may result (B)</p> Signup and view all the answers

How does the endocrine system contribute to maintaining balanced levels of Mullerian Inhibitory Factor (MIF) and Anti-Mullerian Hormone (AMH)?

<p>By ensuring that MIF and AMH levels remain balanced (A)</p> Signup and view all the answers

What role does the SRY gene play in sexual development?

<p>Triggers the synthesis of testosterone (A)</p> Signup and view all the answers

How does testosterone influence embryonic development?

<p>Directs the development of male internal and external reproductive structures (C)</p> Signup and view all the answers

Which statement accurately describes the function of Testis Determining Factor (TDF) in sexual differentiation?

<p>Influences the development of testes and sperm production (A)</p> Signup and view all the answers

Which enzyme is primarily responsible for converting pregnenolone into 17-hydroxyprogesterone in the synthesis of testosterone?

<p>17α-hydroxylase/17,20-lyase (C)</p> Signup and view all the answers

In female embryos, what role does testosterone play in the development of the reproductive system?

<p>Develops the Mullerian ducts (C)</p> Signup and view all the answers

Which of the following disorders might result from disruptions in testosterone regulation during embryonic development?

<p>Androgen insensitivity syndrome (B)</p> Signup and view all the answers

Where is the mesonephric/wolffian duct derived from?

<p>Mesoderm (B)</p> Signup and view all the answers

Which of thee following is the main driver of penis and scrotum formation prior to puberty?

<p>DHT (C)</p> Signup and view all the answers

Patients likely have a deficiency in which of the following if they have male internal genitalia and atypical/feminized external genitalia at birth?

<p>5α-reductase (D)</p> Signup and view all the answers

What is a potential complication of an undescended testicle?

<p>Higher risk of developing testicular cancer (B)</p> Signup and view all the answers

What is the recommended surgical procedure for most cases of cryptorchidism?

<p>Orchiopexy (A)</p> Signup and view all the answers

Why is it particularly important to monitor and treat cryptorchidism in preterm infants?

<p>To promote proper testicular descent and development (A)</p> Signup and view all the answers

How do epigenetic modifications, such as DNA methylation and histone acetylation, contribute to the regulation of the SRY gene expression?

<p>DNA methylation silences the SRY gene on the X chromosome, while histone acetylation enhances its expression on the Y chromosome. (C)</p> Signup and view all the answers

What impact do post-translational modifications, like phosphorylation and ubiquitination, have on the SRY gene activity?

<p>They influence the interaction of SRY with other proteins. (B)</p> Signup and view all the answers

In human biology, what can mutations in the SRY gene potentially lead to?

<p>Sex reversal or ambiguous genitalia. (D)</p> Signup and view all the answers

Match the following with they embryonic origin

<p>glans penis / glans clitoris = genital tubercle prostate / Bartholin's glands = UG sinus ventral shaft of penis / labia minora = UG fold scrotum / labia majora = labioscrotal swellings</p> Signup and view all the answers

Match the following treatment options with their descriptions:

<p>Reconstructive surgery = Aims to restore the structure and function of the penis and urinary tract Urinary diversion methods = May involve a Mitrofanoff procedure to create a new urinary tract pathway Sexual and reproductive counseling = Beneficial for adult patients with epispadias and their partners to discuss options Medication therapy = Involves drug treatment to manage symptoms of epispadias</p> Signup and view all the answers

Match the following complications of epispadias with their descriptions:

<p>Urinary incontinence = Can lead to frequent urinary tract infections Chronic renal insufficiency = May occur if the urinary tract is not fully developed Psychological effects = Include self-esteem issues and anxiety that can be addressed through counseling Respiratory distress = Linked to complications arising from epispadias</p> Signup and view all the answers

Match the following actions with their impact on individuals affected by epispadias:

<p>Early diagnosis = Can lead to improved quality of life for those with epispadias Consulting healthcare provider = Essential to obtain the best and most current information available Participating in support groups = Can help address psychological effects of epispadias Avoiding medical consultation = Can hinder effective management of epispadias</p> Signup and view all the answers

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