Hemangioma and Ewing Sarcoma Overview

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Questions and Answers

Oral hemangiomas (OHs) are characterized by what cellular activity?

  • Normal rates of cell turnover.
  • Decreased rate of endothelial cell turnover.
  • Endothelial cell proliferation. (correct)
  • Localized anomalies in vascular morphogenesis.

While hemangiomas and vascular malformations are different, in what way have they been historically perceived?

  • Always recognized as distinct entities in medical literature.
  • Often used interchangeably, leading to confusion. (correct)
  • Clearly distinguished in clinical settings.
  • Consistently differentiated through established diagnostic criteria.

According to Mulliken and Glowacki's classification system, what feature characterizes hemangiomas?

  • Localized anomalies with normal cell turnover.
  • Defects in vascular morphogenesis.
  • Vascular anomalies with decreased cell proliferation.
  • True neoplasms with increased endothelial cell turnover. (correct)

According to Mulliken and Glowacki's classification system, what feature characterizes a vascular malformation?

<p>Localized anomalies with normal cell turnover. (D)</p> Signup and view all the answers

What percentage range is cited for hemangiomas appearing in the head and neck region?

<p>60 to 70 percent (B)</p> Signup and view all the answers

Which anatomical sites are most commonly affected by oral hemangiomas?

<p>Lips, tongue, buccal mucosa, and palate (A)</p> Signup and view all the answers

What is the nature of oral hemangiomas (OHs)?

<p>Benign tumors that arise due to endothelial cell proliferation. (A)</p> Signup and view all the answers

Where in the maxillofacial region have oral hemangiomas (OHs) been specifically observed?

<p>Mandible and maxilla, as well as within the masseter muscle (A)</p> Signup and view all the answers

In the context of Ewing sarcoma, which of the following is true regarding its typical patient population?

<p>It primarily occurs in children and young adults. (C)</p> Signup and view all the answers

What regions of the body are most commonly affected by Ewing sarcoma?

<p>Pelvis, axial skeleton, and extremities (C)</p> Signup and view all the answers

In what percentage of all Ewing tumor cases does the condition present in the head and neck region?

<p>3% to 9% (B)</p> Signup and view all the answers

How does the prognosis of Ewing sarcoma in the head and neck region compare to other sites?

<p>Slightly better than that of other anatomic sites. (C)</p> Signup and view all the answers

What therapeutic approach is considered the treatment of choice for Ewing sarcoma in the head and neck region?

<p>Multimodality therapy (D)</p> Signup and view all the answers

What is the role of vascular morphogenesis in the development of vascular malformations, according to Mulliken and Glowacki?

<p>It leads to localized anomalies or defects. (D)</p> Signup and view all the answers

Oral hemangiomas are sometimes found within the muscles of mastication. What term is used to refer to hemangiomas located in this region?

<p>Intramuscular hemangiomas (D)</p> Signup and view all the answers

If a patient is diagnosed with Ewing sarcoma in the head and neck region, what is the expected first step in their treatment?

<p>Perform an initial biopsy. (A)</p> Signup and view all the answers

What is the expected outcome of following a multimodality therapy approach for Ewing's sarcoma?

<p>Possible long-term survival. (C)</p> Signup and view all the answers

What cellular characteristic distinguishes hemangiomas from vascular malformations?

<p>Hemangiomas exhibit rapid and unregulated cell growth (D)</p> Signup and view all the answers

Which of the following correctly describes how hemangiomas of the mandible and maxilla (central hemangiomas) are classified?

<p>Classified by location in these gnathic bones (C)</p> Signup and view all the answers

How would Ewing sarcoma in the head and neck likely be managed?

<p>Initial biopsy and combination therapy (C)</p> Signup and view all the answers

Which patient population is primarily affected by Ewing sarcoma, a highly malignant tumor of the bone and soft tissues?

<p>Children and young adults (C)</p> Signup and view all the answers

In Ewing sarcoma, cancer treatment options often combine multiple therapeutic approaches. Which of the following accurately reflects treatment?

<p>All of the listed options (D)</p> Signup and view all the answers

Oral hemangiomas (OHs) are relatively rare benign tumors. What location is least likely influenced by lesions of this kind?

<p>Trachea (D)</p> Signup and view all the answers

Multimodality therapy is the treatment of choice when dealing with Ewing sarcoma. Which one of the following options is not used when following this approach?

<p>Administration of antiviral medication (B)</p> Signup and view all the answers

While localized anomalies due to defects in vascular morphogenesis commonly represents vascular malformations, how is cell turnover affected?

<p>There is a nominal rate (B)</p> Signup and view all the answers

Flashcards

Oral Hemangiomas (OHs)

Benign tumors that develop due to endothelial cell proliferation in and around the oral cavity.

Hemangiomas

Neoplasms characterized by proliferation and increased rates of endothelial cell turnover.

Vascular malformations

Localized anomalies due to defects in vascular morphogenesis with normal rates of cell turnover.

Ewing Sarcoma

A highly malignant tumor of bone and soft tissues, most common in children and young adults.

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Ewing Sarcoma Treatment

An initial biopsy, aggressive combination chemotherapy and localized radiotherapy.

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Ewing Sarcoma Appearance

Composed of small round blue cells with scant cytoplasm.

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CD99

A cell surface glycoprotein highly expressed in Ewing sarcoma and other small round cell tumors.

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FLI1

Transcription factor involved in cell differentiation, proliferation, and apoptosis. Expressed in Ewing Sarcoma.

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Study Notes

Hemangioma of Gnathic Bones

  • Oral hemangiomas (OHs) result from endothelial cell proliferation.
  • OHs are benign tumors in and around the oral cavity.
  • 60 to 70% of hemangiomas occur in the head and neck region.
  • Relatively rare, OHs commonly affect the lips, tongue, buccal mucosa, and palate.
  • Central hemangiomas manifest in the mandible and maxilla.
  • Intramuscular hemangiomas are seen within the masseter and mastication muscles.
  • "Hemangioma" and "vascular malformation" are often used interchangeably, which can cause confusion.
  • Hemangiomas are true neoplasms with endothelial cell proliferation, resulting in increased turnover.
  • Vascular malformations are localized anomalies due to vascular morphogenesis defects, with typical cell turnover rates.

Ewing Sarcoma

  • Ewing sarcoma is a highly malignant tumor of bone and soft tissues.
  • Primarily found in children and young adults.
  • Most commonly in the pelvis, axial skeleton, and extremities.
  • In the head and neck, it accounts for 3% to 9% of all Ewing tumors.
  • The prognosis for Ewing's sarcoma in the head and neck region is slightly better than in other sites.
  • Multimodality therapy, including biopsy, chemotherapy, and radiotherapy, is the treatment of choice and may lead to long-term survival.

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