T.10 La RNA Pol III
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Questions and Answers

How many subunits does RNA Pol III consist of?

  • 19
  • 17 (correct)
  • 20
  • 15

What is the main function of RNA Pol III?

  • To transcribe a limited number of genes (correct)
  • To translate mRNAs
  • To catalyze protein synthesis
  • To transcribe all genes

What is the main difference between genes transcribed by RNA Pol III and other polymerases?

  • Sequence of the gene
  • Size of the gene
  • Type of RNA produced (correct)
  • Function of the gene product

What is the name of the additional trimer found in RNA Pol III?

<p>C82/C34/C31 (D)</p> Signup and view all the answers

What is unique about the promoters of genes type I and II?

<p>They are located within the sequence to be transcribed. (C)</p> Signup and view all the answers

What is the role of TFIIIA in the formation of the initiation complex?

<p>It binds to the C box and the A box. (B)</p> Signup and view all the answers

What is common to all three types of promoters?

<p>The presence of TBP. (C)</p> Signup and view all the answers

What is the difference between TFIIIB-1 and TFIIIB-2?

<p>TFIIIB-1 is found in genes type I, while TFIIIB-2 is found in genes type II. (B)</p> Signup and view all the answers

What is the role of BRF1 in the formation of the initiation complex?

<p>It is a subunit of TFIIIB. (C)</p> Signup and view all the answers

What is the significance of the nucleosome in genes type I?

<p>It enhances the transcription of the gene. (D)</p> Signup and view all the answers

What is the function of SNAPc?

<p>It binds to the TBP. (C)</p> Signup and view all the answers

What is the difference between the initiation complex of genes type I and II?

<p>The RNA Pol III is situated differently. (A)</p> Signup and view all the answers

What is the role of TFIIIC in the formation of the initiation complex?

<p>It binds to the A box and the B box. (B)</p> Signup and view all the answers

What is the composition of SNAPc?

<p>It is composed of 5 subunits, including SNAPc190. (A)</p> Signup and view all the answers

In which type of cells is the transcription of RNA Pol III not required to be very high?

<p>Retinal cells (C)</p> Signup and view all the answers

What is the effect of retinoblastoma on the transcription of RNA Pol III?

<p>It blocks the complex TFIIIB partially (A)</p> Signup and view all the answers

What is the result of a mutation in the retinoblastoma gene?

<p>An increase in cell growth (B)</p> Signup and view all the answers

What is the function of the heterotrimer C82/C34/C31 in RNA Pol III?

<p>It allows the RNA Pol III to rapidly terminate and reinitiate transcription (D)</p> Signup and view all the answers

What is the characteristic of RNA Pol I that allows it to overcome transcriptional pauses?

<p>It has a permanent system to solve transcriptional pauses (D)</p> Signup and view all the answers

What is the difference between the RNA Pol I and RNA Pol II in terms of transcriptional pauses?

<p>RNA Pol II needs the help of external factors to overcome transcriptional pauses (C)</p> Signup and view all the answers

What is the result of a mutation in the retinoblastoma gene in terms of cell growth?

<p>An increase in cell growth (C)</p> Signup and view all the answers

What is the function of the retinoblastoma protein in the regulation of RNA Pol III transcription?

<p>It blocks the transcription of RNA Pol III partially (A)</p> Signup and view all the answers

What is the name of the protein that regulates the transcription of the 5S rRNA gene?

<p>TFIIIA (B)</p> Signup and view all the answers

What is the function of the zinc fingers in the TFIIIA protein?

<p>To recognize specific DNA sequences (A)</p> Signup and view all the answers

What happens to the TFIIIA protein when there is an excess of 5S rRNA?

<p>It forms a complex with the excess 5S rRNA, blocking its activity (D)</p> Signup and view all the answers

What is the name of the mechanism by which the 5S rRNA gene is regulated?

<p>Autogenous regulation (C)</p> Signup and view all the answers

What is the function of the Maf1 protein in response to stress?

<p>To inhibit the transcription of the 5S rRNA gene (A)</p> Signup and view all the answers

What is the effect of stress on the Maf1 protein?

<p>It becomes dephosphorylated and moves to the nucleus (C)</p> Signup and view all the answers

What is the function of the retinoblastoma protein?

<p>To suppress tumor formation (C)</p> Signup and view all the answers

What is the type of RNA that is transcribed by RNA polymerase III?

<p>rRNA, tRNA, and other small RNAs (B)</p> Signup and view all the answers

What is the name of the complex that forms between TFIIIA and the promoter region of the 5S rRNA gene?

<p>TFIIIA-DNA complex (A)</p> Signup and view all the answers

What is the function of the TFIIIB complex?

<p>To initiate the transcription of the 5S rRNA gene (B)</p> Signup and view all the answers

What can be said about the complex of transcription?

<p>It makes a loop in the DNA. (C)</p> Signup and view all the answers

What is the function of the heterotrimer in RNA Pol III?

<p>It extends helices that help to maintain the DNA in place. (B)</p> Signup and view all the answers

Why does RNA Pol III have a 'hanging' center active?

<p>Because it facilitates rapid termination of the RNA polymerase. (B)</p> Signup and view all the answers

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