T.10 La RNA Pol III
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Questions and Answers

How many subunits does RNA Pol III consist of?

  • 19
  • 17 (correct)
  • 20
  • 15

    • What is the main function of RNA Pol III?

  • To transcribe a limited number of genes (correct)
  • To translate mRNAs
  • To catalyze protein synthesis
  • To transcribe all genes

    • What is the main difference between genes transcribed by RNA Pol III and other polymerases?

  • Sequence of the gene
  • Size of the gene
  • Type of RNA produced (correct)
  • Function of the gene product

    • What is the name of the additional trimer found in RNA Pol III?

    <p>C82/C34/C31</p> Signup and view all the answers

    What is unique about the promoters of genes type I and II?

    <p>They are located within the sequence to be transcribed.</p> Signup and view all the answers

    What is the role of TFIIIA in the formation of the initiation complex?

    <p>It binds to the C box and the A box.</p> Signup and view all the answers

    What is common to all three types of promoters?

    <p>The presence of TBP.</p> Signup and view all the answers

    What is the difference between TFIIIB-1 and TFIIIB-2?

    <p>TFIIIB-1 is found in genes type I, while TFIIIB-2 is found in genes type II.</p> Signup and view all the answers

    What is the role of BRF1 in the formation of the initiation complex?

    <p>It is a subunit of TFIIIB.</p> Signup and view all the answers

    What is the significance of the nucleosome in genes type I?

    <p>It enhances the transcription of the gene.</p> Signup and view all the answers

    What is the function of SNAPc?

    <p>It binds to the TBP.</p> Signup and view all the answers

    What is the difference between the initiation complex of genes type I and II?

    <p>The RNA Pol III is situated differently.</p> Signup and view all the answers

    What is the role of TFIIIC in the formation of the initiation complex?

    <p>It binds to the A box and the B box.</p> Signup and view all the answers

    What is the composition of SNAPc?

    <p>It is composed of 5 subunits, including SNAPc190.</p> Signup and view all the answers

    In which type of cells is the transcription of RNA Pol III not required to be very high?

    <p>Retinal cells</p> Signup and view all the answers

    What is the effect of retinoblastoma on the transcription of RNA Pol III?

    <p>It blocks the complex TFIIIB partially</p> Signup and view all the answers

    What is the result of a mutation in the retinoblastoma gene?

    <p>An increase in cell growth</p> Signup and view all the answers

    What is the function of the heterotrimer C82/C34/C31 in RNA Pol III?

    <p>It allows the RNA Pol III to rapidly terminate and reinitiate transcription</p> Signup and view all the answers

    What is the characteristic of RNA Pol I that allows it to overcome transcriptional pauses?

    <p>It has a permanent system to solve transcriptional pauses</p> Signup and view all the answers

    What is the difference between the RNA Pol I and RNA Pol II in terms of transcriptional pauses?

    <p>RNA Pol II needs the help of external factors to overcome transcriptional pauses</p> Signup and view all the answers

    What is the result of a mutation in the retinoblastoma gene in terms of cell growth?

    <p>An increase in cell growth</p> Signup and view all the answers

    What is the function of the retinoblastoma protein in the regulation of RNA Pol III transcription?

    <p>It blocks the transcription of RNA Pol III partially</p> Signup and view all the answers

    What is the name of the protein that regulates the transcription of the 5S rRNA gene?

    <p>TFIIIA</p> Signup and view all the answers

    What is the function of the zinc fingers in the TFIIIA protein?

    <p>To recognize specific DNA sequences</p> Signup and view all the answers

    What happens to the TFIIIA protein when there is an excess of 5S rRNA?

    <p>It forms a complex with the excess 5S rRNA, blocking its activity</p> Signup and view all the answers

    What is the name of the mechanism by which the 5S rRNA gene is regulated?

    <p>Autogenous regulation</p> Signup and view all the answers

    What is the function of the Maf1 protein in response to stress?

    <p>To inhibit the transcription of the 5S rRNA gene</p> Signup and view all the answers

    What is the effect of stress on the Maf1 protein?

    <p>It becomes dephosphorylated and moves to the nucleus</p> Signup and view all the answers

    What is the function of the retinoblastoma protein?

    <p>To suppress tumor formation</p> Signup and view all the answers

    What is the type of RNA that is transcribed by RNA polymerase III?

    <p>rRNA, tRNA, and other small RNAs</p> Signup and view all the answers

    What is the name of the complex that forms between TFIIIA and the promoter region of the 5S rRNA gene?

    <p>TFIIIA-DNA complex</p> Signup and view all the answers

    What is the function of the TFIIIB complex?

    <p>To initiate the transcription of the 5S rRNA gene</p> Signup and view all the answers

    What can be said about the complex of transcription?

    <p>It makes a loop in the DNA.</p> Signup and view all the answers

    What is the function of the heterotrimer in RNA Pol III?

    <p>It extends helices that help to maintain the DNA in place.</p> Signup and view all the answers

    Why does RNA Pol III have a 'hanging' center active?

    <p>Because it facilitates rapid termination of the RNA polymerase.</p> Signup and view all the answers

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