Top 300: Analgesics
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Questions and Answers

Acetaminophen Pharmacological Class:

  • Centrally acting analgesic (correct)
  • NSAID
  • Urinary Analgesic
  • COX-2 Selective anti-inflamamtory agent

Acetaminophen contraindications:

  • Renal insufficiency
  • NSAID allergy or hypersensitivity; CABG surgery
  • Hepatic disease or impairment; hypersensitivity (correct)
  • History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other nonsteroidal anti-inflammatory drugs Major substrate of CYP2C9

Acetaminophen Precaution:

  • Caution in older adults due to GI bleeds; caution in hypertension, fluid retention, and HF; increase risk of renal injury; avoid in pregnancy
  • Alcoholism; hepatic impairment; limit dose from all sources/routes to <4g/day (correct)
  • Caution in glucose-6-phosphate dehydrogenase (G6PD) deficiency - may lead to hemolytic anemia
  • Increased risk of systemic absorption associated with irritated or broken skin, application of external heat sources, a covered application site, and large doses or large treatment areas

Acetominophen ADR:

<p>Hepatotoxicity (C)</p> Signup and view all the answers

Acetaminophen Counseling Points:

<p>limit dose from all sources/routes to &lt;4g/day; be aware of combination products containing acetaminophen; avoid alcohol use (D)</p> Signup and view all the answers

Ibuprofen Pharmacological Class

<p>NSAID (B)</p> Signup and view all the answers

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