Adverse Drug Interactions of Antibiotics
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Questions and Answers

What is a notable adverse drug interaction exhibited by tetracycline?

  • Interaction with Warfarin
  • Interaction with dairy, antacids, vitamins (correct)
  • Interaction with oral contraceptives
  • Interaction with alcohol, lithium

What is a potential adverse drug interaction of metronidazole?

  • Interaction with NSAIDS
  • Interaction with Warfarin
  • Interaction with alcohol, lithium (correct)
  • Interaction with digoxin

What is a difficulty in determining drug-drug interaction risks?

  • Unavailability of data on drug interactions
  • Complexity of drug metabolism
  • Variability in patient response
  • All of the above (correct)

What is a potential adverse drug interaction of azithromycin or clarithromycin?

<p>Interaction with digoxin (D)</p> Signup and view all the answers

What is a potential adverse drug interaction of amoxicillin with Warfarin?

<p>Bleeding risk increase (high anti-coagulation) (D)</p> Signup and view all the answers

What is a mechanism of adverse drug interaction?

<p>All of the above (D)</p> Signup and view all the answers

What is a potential adverse drug interaction of NSAIDs?

<p>All of the above (D)</p> Signup and view all the answers

What is the potential consequence of co-administering epinephrine with tricyclic antidepressants (TCA's)?

<p>Increased risk of cardiac arrhythmias (D)</p> Signup and view all the answers

Which of the following drugs is most likely to displace a highly protein-bound drug from its binding site?

<p>Warfarin (C)</p> Signup and view all the answers

What is the primary mechanism of adverse drug interactions involving NSAIDs and lithium?

<p>Reduced lithium excretion (D)</p> Signup and view all the answers

Which of the following antibiotics is most likely to interact with benzodiazepines?

<p>macrolide antibiotics (azithromycin and clarithromycin) (A)</p> Signup and view all the answers

What is a common feature of drugs involved in adverse drug interactions?

<p>Narrow therapeutic range (C)</p> Signup and view all the answers

Which of the following drugs can interact with digoxin, leading to increased digoxin concentrations?

<p>Clarithromycin (D)</p> Signup and view all the answers

What is the potential consequence of co-administering benzodiazepines with opioids?

<p>Enhanced sedative effects (D)</p> Signup and view all the answers

What is the mechanism of adverse drug interaction between NSAIDs and lithium?

<p>Inhibition of lithium excretion (C)</p> Signup and view all the answers

Which of the following antibiotics is likely to interact with benzodiazepines?

<p>Macrolide antibiotics (D)</p> Signup and view all the answers

What is a common feature of drugs involved in adverse drug interactions?

<p>High protein binding (A)</p> Signup and view all the answers

Which of the following drugs can interact with digoxin, leading to increased digoxin concentrations?

<p>Clarithromycin and Azithromycin (macrolide antibiotics) (A)</p> Signup and view all the answers

What is the potential consequence of co-administering benzodiazepines with opioids?

<p>Increased risk of respiratory depression (D)</p> Signup and view all the answers

What is the primary mechanism by which azithromycin and clarithromycin interact with digoxin?

<p>Induction of P-glycoprotein efflux (A)</p> Signup and view all the answers

What is the primary mechanism by which metronidazole interacts with lithium?

<p>Inhibition of lithium excretion (B)</p> Signup and view all the answers

Which of the following drugs is most likely to interact with Warfarin?

<p>Amoxicillin (D)</p> Signup and view all the answers

What is the primary mechanism by which NSAIDs interact with ethanol?

<p>Increased risk of gastrointestinal bleeding (D)</p> Signup and view all the answers

Which of the following antibiotics is most likely to interact with benzodiazepines?

<p>Clarithromycin and Azithromycin (macrolide antibiotics) (B)</p> Signup and view all the answers

What is the primary mechanism by which epinephrine interacts with cocaine or methamphetamine?

<p>Increased risk of cardiac arrhythmias (D)</p> Signup and view all the answers

Which antibiotic is likely to exhibit an adverse drug interaction with Warfarin?

<p>Amoxicillin (B)</p> Signup and view all the answers

What is a potential adverse drug interaction of metronidazole with lithium?

<p>Increased lithium levels (A)</p> Signup and view all the answers

What is a potential adverse drug interaction of NSAIDs with ethanol?

<p>Increased gastrointestinal bleeding (D)</p> Signup and view all the answers

Which of the following antibiotics is likely to interact with digoxin?

<p>Clarithromycin and Azithromycin (macrolide antibiotics) (D)</p> Signup and view all the answers

What is a potential adverse drug interaction of epinephrine with cocaine or methamphetamine?

<p>Cardiac arrhythmias (A)</p> Signup and view all the answers

Which of the following NSAIDs is likely to interact with SSRIs?

<p>All of the above (D)</p> Signup and view all the answers

Which drug class is most likely to interact with macrolide antibiotics or protease inhibitors leading to inhibition of CYP3A4?

<p>Benzodiazepines (C)</p> Signup and view all the answers

What is a common feature of drugs that are highly protein-bound?

<p>They are frequently involved in adverse drug interactions (C)</p> Signup and view all the answers

Which drug is most likely to interact with lithium, leading to increased lithium concentrations?

<p>Metronidazole (C)</p> Signup and view all the answers

What is the primary mechanism of adverse drug interactions involving epinephrine and tricyclic antidepressants?

<p>Increased risk of cardiac arrhythmias (A)</p> Signup and view all the answers

Which drug class is most likely to interact with antihistamines, leading to increased sedative effects?

<p>Benzodiazepines (C)</p> Signup and view all the answers

What is the primary mechanism of adverse drug interactions between benzodiazepines and macrolide antibiotics?

<p>Inhibition of CYP3A4 (A)</p> Signup and view all the answers

Which of the following drugs is most likely to displace warfarin from its binding site, leading to increased warfarin concentrations?

<p>Aspirin (D)</p> Signup and view all the answers

What is the primary mechanism of adverse drug interactions between NSAIDs and lithium?

<p>Inhibition of renal excretion (C)</p> Signup and view all the answers

What is the primary mechanism of adverse drug interactions between epinephrine and tricyclic antidepressants?

<p>Increased sympathomimetic effects (B)</p> Signup and view all the answers

What is the primary mechanism by which NSAIDs interact with Warfarin?

<p>Displacement of highly protein-bound Warfarin from its binding sites (C)</p> Signup and view all the answers

What is a common feature of drugs that are highly protein-bound?

<p>Narrow therapeutic index (D)</p> Signup and view all the answers

What is a common feature of drugs that are highly protein-bound?

<p>They are easily displaced from their binding sites (A)</p> Signup and view all the answers

Which of the following antibiotics is most likely to interact with benzodiazepines, leading to increased sedative effects?

<p>Macrolide antibiotics (D)</p> Signup and view all the answers

What is a potential adverse drug interaction of benzodiazepines with opioids?

<p>Increased risk of respiratory depression (A)</p> Signup and view all the answers

What is a common feature of drugs involved in adverse drug interactions?

<p>They have a narrow therapeutic index (D)</p> Signup and view all the answers

What is the primary mechanism of adverse drug interactions involving NSAIDs and ethanol?

<p>Enhanced gastrointestinal toxicity, leading to increased bleeding risk (C)</p> Signup and view all the answers

What is the mechanism by which azithromycin or clarithromycin interacts with digoxin, leading to increased digoxin concentrations?

<p>P-glycoprotein inhibition, leading to increased digoxin concentrations (B)</p> Signup and view all the answers

What is the primary mechanism of adverse drug interactions involving benzodiazepines and opioids?

<p>Enhanced sedative effects, leading to increased risk of respiratory depression (D)</p> Signup and view all the answers

What is the mechanism by which epinephrine interacts with tricyclic antidepressants, leading to increased risk of hypertension?

<p>Enhanced vasoconstrictive effects, leading to increased blood pressure (D)</p> Signup and view all the answers

What is the primary mechanism of adverse drug interactions involving metronidazole and lithium?

<p>Inhibition of lithium excretion, leading to increased lithium concentrations (D)</p> Signup and view all the answers

What is the mechanism by which tetracycline exhibits an adverse drug interaction?

<p>Chelation of divalent cations, leading to decreased drug absorption (B)</p> Signup and view all the answers

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