Adverse Drug Interactions of Antibiotics
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Questions and Answers

What is a notable adverse drug interaction exhibited by tetracycline?

  • Interaction with Warfarin
  • Interaction with dairy, antacids, vitamins (correct)
  • Interaction with oral contraceptives
  • Interaction with alcohol, lithium

    • What is a potential adverse drug interaction of metronidazole?

  • Interaction with NSAIDS
  • Interaction with Warfarin
  • Interaction with alcohol, lithium (correct)
  • Interaction with digoxin

    • What is a difficulty in determining drug-drug interaction risks?

  • Unavailability of data on drug interactions
  • Complexity of drug metabolism
  • Variability in patient response
  • All of the above (correct)

    • What is a potential adverse drug interaction of azithromycin or clarithromycin?

    <p>Interaction with digoxin</p> Signup and view all the answers

    What is a potential adverse drug interaction of amoxicillin with Warfarin?

    <p>Bleeding risk increase (high anti-coagulation)</p> Signup and view all the answers

    What is a mechanism of adverse drug interaction?

    <p>All of the above</p> Signup and view all the answers

    What is a potential adverse drug interaction of NSAIDs?

    <p>All of the above</p> Signup and view all the answers

    What is the potential consequence of co-administering epinephrine with tricyclic antidepressants (TCA's)?

    <p>Increased risk of cardiac arrhythmias</p> Signup and view all the answers

    Which of the following drugs is most likely to displace a highly protein-bound drug from its binding site?

    <p>Warfarin</p> Signup and view all the answers

    What is the primary mechanism of adverse drug interactions involving NSAIDs and lithium?

    <p>Reduced lithium excretion</p> Signup and view all the answers

    Which of the following antibiotics is most likely to interact with benzodiazepines?

    <p>macrolide antibiotics (azithromycin and clarithromycin)</p> Signup and view all the answers

    What is a common feature of drugs involved in adverse drug interactions?

    <p>Narrow therapeutic range</p> Signup and view all the answers

    Which of the following drugs can interact with digoxin, leading to increased digoxin concentrations?

    <p>Clarithromycin</p> Signup and view all the answers

    What is the potential consequence of co-administering benzodiazepines with opioids?

    <p>Enhanced sedative effects</p> Signup and view all the answers

    What is the mechanism of adverse drug interaction between NSAIDs and lithium?

    <p>Inhibition of lithium excretion</p> Signup and view all the answers

    Which of the following antibiotics is likely to interact with benzodiazepines?

    <p>Macrolide antibiotics</p> Signup and view all the answers

    What is a common feature of drugs involved in adverse drug interactions?

    <p>High protein binding</p> Signup and view all the answers

    Which of the following drugs can interact with digoxin, leading to increased digoxin concentrations?

    <p>Clarithromycin and Azithromycin (macrolide antibiotics)</p> Signup and view all the answers

    What is the potential consequence of co-administering benzodiazepines with opioids?

    <p>Increased risk of respiratory depression</p> Signup and view all the answers

    What is the primary mechanism by which azithromycin and clarithromycin interact with digoxin?

    <p>Induction of P-glycoprotein efflux</p> Signup and view all the answers

    What is the primary mechanism by which metronidazole interacts with lithium?

    <p>Inhibition of lithium excretion</p> Signup and view all the answers

    Which of the following drugs is most likely to interact with Warfarin?

    <p>Amoxicillin</p> Signup and view all the answers

    What is the primary mechanism by which NSAIDs interact with ethanol?

    <p>Increased risk of gastrointestinal bleeding</p> Signup and view all the answers

    Which of the following antibiotics is most likely to interact with benzodiazepines?

    <p>Clarithromycin and Azithromycin (macrolide antibiotics)</p> Signup and view all the answers

    What is the primary mechanism by which epinephrine interacts with cocaine or methamphetamine?

    <p>Increased risk of cardiac arrhythmias</p> Signup and view all the answers

    Which antibiotic is likely to exhibit an adverse drug interaction with Warfarin?

    <p>Amoxicillin</p> Signup and view all the answers

    What is a potential adverse drug interaction of metronidazole with lithium?

    <p>Increased lithium levels</p> Signup and view all the answers

    What is a potential adverse drug interaction of NSAIDs with ethanol?

    <p>Increased gastrointestinal bleeding</p> Signup and view all the answers

    Which of the following antibiotics is likely to interact with digoxin?

    <p>Clarithromycin and Azithromycin (macrolide antibiotics)</p> Signup and view all the answers

    What is a potential adverse drug interaction of epinephrine with cocaine or methamphetamine?

    <p>Cardiac arrhythmias</p> Signup and view all the answers

    Which of the following NSAIDs is likely to interact with SSRIs?

    <p>All of the above</p> Signup and view all the answers

    Which drug class is most likely to interact with macrolide antibiotics or protease inhibitors leading to inhibition of CYP3A4?

    <p>Benzodiazepines</p> Signup and view all the answers

    What is a common feature of drugs that are highly protein-bound?

    <p>They are frequently involved in adverse drug interactions</p> Signup and view all the answers

    Which drug is most likely to interact with lithium, leading to increased lithium concentrations?

    <p>Metronidazole</p> Signup and view all the answers

    What is the primary mechanism of adverse drug interactions involving epinephrine and tricyclic antidepressants?

    <p>Increased risk of cardiac arrhythmias</p> Signup and view all the answers

    Which drug class is most likely to interact with antihistamines, leading to increased sedative effects?

    <p>Benzodiazepines</p> Signup and view all the answers

    What is the primary mechanism of adverse drug interactions between benzodiazepines and macrolide antibiotics?

    <p>Inhibition of CYP3A4</p> Signup and view all the answers

    Which of the following drugs is most likely to displace warfarin from its binding site, leading to increased warfarin concentrations?

    <p>Aspirin</p> Signup and view all the answers

    What is the primary mechanism of adverse drug interactions between NSAIDs and lithium?

    <p>Inhibition of renal excretion</p> Signup and view all the answers

    What is the primary mechanism of adverse drug interactions between epinephrine and tricyclic antidepressants?

    <p>Increased sympathomimetic effects</p> Signup and view all the answers

    What is the primary mechanism by which NSAIDs interact with Warfarin?

    <p>Displacement of highly protein-bound Warfarin from its binding sites</p> Signup and view all the answers

    What is a common feature of drugs that are highly protein-bound?

    <p>Narrow therapeutic index</p> Signup and view all the answers

    What is a common feature of drugs that are highly protein-bound?

    <p>They are easily displaced from their binding sites</p> Signup and view all the answers

    Which of the following antibiotics is most likely to interact with benzodiazepines, leading to increased sedative effects?

    <p>Macrolide antibiotics</p> Signup and view all the answers

    What is a potential adverse drug interaction of benzodiazepines with opioids?

    <p>Increased risk of respiratory depression</p> Signup and view all the answers

    What is a common feature of drugs involved in adverse drug interactions?

    <p>They have a narrow therapeutic index</p> Signup and view all the answers

    What is the primary mechanism of adverse drug interactions involving NSAIDs and ethanol?

    <p>Enhanced gastrointestinal toxicity, leading to increased bleeding risk</p> Signup and view all the answers

    What is the mechanism by which azithromycin or clarithromycin interacts with digoxin, leading to increased digoxin concentrations?

    <p>P-glycoprotein inhibition, leading to increased digoxin concentrations</p> Signup and view all the answers

    What is the primary mechanism of adverse drug interactions involving benzodiazepines and opioids?

    <p>Enhanced sedative effects, leading to increased risk of respiratory depression</p> Signup and view all the answers

    What is the mechanism by which epinephrine interacts with tricyclic antidepressants, leading to increased risk of hypertension?

    <p>Enhanced vasoconstrictive effects, leading to increased blood pressure</p> Signup and view all the answers

    What is the primary mechanism of adverse drug interactions involving metronidazole and lithium?

    <p>Inhibition of lithium excretion, leading to increased lithium concentrations</p> Signup and view all the answers

    What is the mechanism by which tetracycline exhibits an adverse drug interaction?

    <p>Chelation of divalent cations, leading to decreased drug absorption</p> Signup and view all the answers

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