52 Questions
What is a notable adverse drug interaction exhibited by tetracycline?
Interaction with dairy, antacids, vitamins
What is a potential adverse drug interaction of metronidazole?
Interaction with alcohol, lithium
What is a difficulty in determining drug-drug interaction risks?
All of the above
What is a potential adverse drug interaction of azithromycin or clarithromycin?
Interaction with digoxin
What is a potential adverse drug interaction of amoxicillin with Warfarin?
Bleeding risk increase (high anti-coagulation)
What is a mechanism of adverse drug interaction?
All of the above
What is a potential adverse drug interaction of NSAIDs?
All of the above
What is the potential consequence of co-administering epinephrine with tricyclic antidepressants (TCA's)?
Increased risk of cardiac arrhythmias
Which of the following drugs is most likely to displace a highly protein-bound drug from its binding site?
Warfarin
What is the primary mechanism of adverse drug interactions involving NSAIDs and lithium?
Reduced lithium excretion
Which of the following antibiotics is most likely to interact with benzodiazepines?
macrolide antibiotics (azithromycin and clarithromycin)
What is a common feature of drugs involved in adverse drug interactions?
Narrow therapeutic range
Which of the following drugs can interact with digoxin, leading to increased digoxin concentrations?
Clarithromycin
What is the potential consequence of co-administering benzodiazepines with opioids?
Enhanced sedative effects
What is the mechanism of adverse drug interaction between NSAIDs and lithium?
Inhibition of lithium excretion
Which of the following antibiotics is likely to interact with benzodiazepines?
Macrolide antibiotics
What is a common feature of drugs involved in adverse drug interactions?
High protein binding
Which of the following drugs can interact with digoxin, leading to increased digoxin concentrations?
Clarithromycin and Azithromycin (macrolide antibiotics)
What is the potential consequence of co-administering benzodiazepines with opioids?
Increased risk of respiratory depression
What is the primary mechanism by which azithromycin and clarithromycin interact with digoxin?
Induction of P-glycoprotein efflux
What is the primary mechanism by which metronidazole interacts with lithium?
Inhibition of lithium excretion
Which of the following drugs is most likely to interact with Warfarin?
Amoxicillin
What is the primary mechanism by which NSAIDs interact with ethanol?
Increased risk of gastrointestinal bleeding
Which of the following antibiotics is most likely to interact with benzodiazepines?
Clarithromycin and Azithromycin (macrolide antibiotics)
What is the primary mechanism by which epinephrine interacts with cocaine or methamphetamine?
Increased risk of cardiac arrhythmias
Which antibiotic is likely to exhibit an adverse drug interaction with Warfarin?
Amoxicillin
What is a potential adverse drug interaction of metronidazole with lithium?
Increased lithium levels
What is a potential adverse drug interaction of NSAIDs with ethanol?
Increased gastrointestinal bleeding
Which of the following antibiotics is likely to interact with digoxin?
Clarithromycin and Azithromycin (macrolide antibiotics)
What is a potential adverse drug interaction of epinephrine with cocaine or methamphetamine?
Cardiac arrhythmias
Which of the following NSAIDs is likely to interact with SSRIs?
All of the above
Which drug class is most likely to interact with macrolide antibiotics or protease inhibitors leading to inhibition of CYP3A4?
Benzodiazepines
What is a common feature of drugs that are highly protein-bound?
They are frequently involved in adverse drug interactions
Which drug is most likely to interact with lithium, leading to increased lithium concentrations?
Metronidazole
What is the primary mechanism of adverse drug interactions involving epinephrine and tricyclic antidepressants?
Increased risk of cardiac arrhythmias
Which drug class is most likely to interact with antihistamines, leading to increased sedative effects?
Benzodiazepines
What is the primary mechanism of adverse drug interactions between benzodiazepines and macrolide antibiotics?
Inhibition of CYP3A4
Which of the following drugs is most likely to displace warfarin from its binding site, leading to increased warfarin concentrations?
Aspirin
What is the primary mechanism of adverse drug interactions between NSAIDs and lithium?
Inhibition of renal excretion
What is the primary mechanism of adverse drug interactions between epinephrine and tricyclic antidepressants?
Increased sympathomimetic effects
What is the primary mechanism by which NSAIDs interact with Warfarin?
Displacement of highly protein-bound Warfarin from its binding sites
What is a common feature of drugs that are highly protein-bound?
Narrow therapeutic index
What is a common feature of drugs that are highly protein-bound?
They are easily displaced from their binding sites
Which of the following antibiotics is most likely to interact with benzodiazepines, leading to increased sedative effects?
Macrolide antibiotics
What is a potential adverse drug interaction of benzodiazepines with opioids?
Increased risk of respiratory depression
What is a common feature of drugs involved in adverse drug interactions?
They have a narrow therapeutic index
What is the primary mechanism of adverse drug interactions involving NSAIDs and ethanol?
Enhanced gastrointestinal toxicity, leading to increased bleeding risk
What is the mechanism by which azithromycin or clarithromycin interacts with digoxin, leading to increased digoxin concentrations?
P-glycoprotein inhibition, leading to increased digoxin concentrations
What is the primary mechanism of adverse drug interactions involving benzodiazepines and opioids?
Enhanced sedative effects, leading to increased risk of respiratory depression
What is the mechanism by which epinephrine interacts with tricyclic antidepressants, leading to increased risk of hypertension?
Enhanced vasoconstrictive effects, leading to increased blood pressure
What is the primary mechanism of adverse drug interactions involving metronidazole and lithium?
Inhibition of lithium excretion, leading to increased lithium concentrations
What is the mechanism by which tetracycline exhibits an adverse drug interaction?
Chelation of divalent cations, leading to decreased drug absorption
This quiz assesses your knowledge of adverse drug interactions involving various antibiotics, including tetracycline, metronidazole, amoxicillin, and more. Learn how these antibiotics interact with other medications and substances.
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