Adverse Drug Interactions
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Questions and Answers

What adverse drug interaction is associated with tetracycline?

  • Interaction with Warfarin
  • Interaction with alcohol
  • Interaction with oral contraceptives (correct)
  • Interaction with digoxin

Which antibiotic is known to interact with Warfarin?

  • Azithromycin
  • Clarithromycin
  • Amoxicillin (correct)
  • Metronidazole

What is a potential interaction of metronidazole?

  • Interaction with digoxin
  • Interaction with epinephrine
  • Interaction with lithium (correct)
  • Interaction with benzodiazepines

What is a common difficulty in determining drug-drug interaction risks?

<p>Unknown (C)</p> Signup and view all the answers

Which drug class is known to interact with SSRIs?

<p>NSAIDs (B)</p> Signup and view all the answers

What is a potential interaction of azithromycin or clarithromycin?

<p>Interaction with digoxin (A)</p> Signup and view all the answers

What is a mechanism of adverse drug interactions?

<p>Unknown (D)</p> Signup and view all the answers

What is the potential consequence of combining epinephrine with tricyclic antidepressants?

<p>Increased risk of arrhythmias (A)</p> Signup and view all the answers

Which of the following is a common feature of drugs involved in adverse drug interactions?

<p>Narrow therapeutic index (D)</p> Signup and view all the answers

What is the potential consequence of combining benzodiazepines with opioids or antihistamines?

<p>Increased risk of respiratory depression (C)</p> Signup and view all the answers

Which of the following drugs is frequently involved in adverse drug interactions due to its high protein binding?

<p>Warfarin (A)</p> Signup and view all the answers

What is the potential consequence of combining NSAIDs with lithium?

<p>Increased lithium toxicity (D)</p> Signup and view all the answers

Which of the following drugs can displace highly protein-bound drugs, leading to adverse interactions?

<p>Sulfonamides (D)</p> Signup and view all the answers

What is the potential consequence of combining clarithromycin with digoxin?

<p>Increased risk of digoxin toxicity (A)</p> Signup and view all the answers

What is a potential consequence of combining antibiotics with oral contraceptives?

<p>Reduced efficacy of the oral contraceptive (A)</p> Signup and view all the answers

What is a common characteristic of drugs involved in adverse drug interactions?

<p>High protein binding (A)</p> Signup and view all the answers

What is a potential interaction of metronidazole with another drug?

<p>All of the above (D)</p> Signup and view all the answers

What is a mechanism of adverse drug interactions?

<p>All of the above (D)</p> Signup and view all the answers

What is a potential interaction of NSAIDs with another drug?

<p>All of the above (D)</p> Signup and view all the answers

What is a difficulty in determining drug-drug interaction risks?

<p>All of the above (D)</p> Signup and view all the answers

What is a potential interaction of azithromycin or clarithromycin with another drug?

<p>Digoxin, increasing the risk of toxicity (B)</p> Signup and view all the answers

What is a common characteristic of drugs that interact with tricyclic antidepressants?

<p>High protein binding (B)</p> Signup and view all the answers

Which class of drugs is known to interact with macrolide antibiotics or protease inhibitors?

<p>Benzodiazepines (A)</p> Signup and view all the answers

What is a common mechanism of adverse drug interactions involving highly protein-bound drugs?

<p>Displacement from protein binding sites (B)</p> Signup and view all the answers

Which of the following drugs is likely to interact with digoxin?

<p>Clarithromycin (A)</p> Signup and view all the answers

What is a common feature of drugs that are highly protein bound?

<p>Increased risk of adverse drug interactions (D)</p> Signup and view all the answers

Which of the following drug classes is known to interact with SSRIs?

<p>Tricyclic antidepressants (C)</p> Signup and view all the answers

What is a common adverse drug interaction involving NSAIDs?

<p>Increased risk of lithium toxicity (C)</p> Signup and view all the answers

What is the primary risk associated with combining epinephrine with tricyclic antidepressants?

<p>Severe hypertension and cardiac arrhythmias (C)</p> Signup and view all the answers

Which of the following drug classes is most likely to interact with macrolide antibiotics or protease inhibitors?

<p>Benzodiazepines (A)</p> Signup and view all the answers

What is a common feature of drugs involved in adverse drug interactions?

<p>High protein binding (A)</p> Signup and view all the answers

Which of the following drugs is highly protein bound and can displace other highly bound drugs, leading to adverse interactions?

<p>Warfarin (B)</p> Signup and view all the answers

What is the primary mechanism underlying the adverse interaction between NSAIDs and lithium?

<p>Displacement from protein binding sites (B)</p> Signup and view all the answers

Which of the following antibiotics is known to interact with digoxin?

<p>Clarithromycin (B)</p> Signup and view all the answers

What is a common characteristic of drugs that interact with tricyclic antidepressants?

<p>Sympathomimetic effects (C)</p> Signup and view all the answers

What is a mechanism by which antibiotics can interact with oral contraceptives?

<p>Altered gut flora, reducing the enterohepatic circulation of the contraceptive (B)</p> Signup and view all the answers

What is a potential consequence of combining metronidazole with lithium?

<p>Increased risk of lithium toxicity due to reduced excretion (B)</p> Signup and view all the answers

What is a characteristic of drugs that are highly protein-bound?

<p>They are more susceptible to displacement interactions with other drugs (B)</p> Signup and view all the answers

What is a potential interaction of azithromycin or clarithromycin with digoxin?

<p>Increased digoxin levels due to inhibition of P-glycoprotein (A)</p> Signup and view all the answers

What is a common difficulty in determining drug-drug interaction risks?

<p>Determining the clinical relevance of in vitro interactions (B)</p> Signup and view all the answers

What is a potential interaction of NSAIDs with ethanol?

<p>Increased risk of gastrointestinal bleeding (A)</p> Signup and view all the answers

What is a mechanism of adverse drug interactions involving NSAIDs and SSRIs?

<p>Increased risk of gastrointestinal bleeding due to synergistic effects (D)</p> Signup and view all the answers

What is a potential consequence of combining antibiotics with oral contraceptives?

<p>Decreased efficacy of oral contraceptives (B)</p> Signup and view all the answers

What is a mechanism by which NSAIDs interact with lithium?

<p>Decreased reabsorption of lithium in the kidneys (A)</p> Signup and view all the answers

What is a common characteristic of drugs involved in adverse drug interactions?

<p>High protein binding (A)</p> Signup and view all the answers

What is a potential interaction of metronidazole with another drug?

<p>Increased risk of neurotoxicity with lithium (C)</p> Signup and view all the answers

What is a mechanism of adverse drug interactions involving highly protein-bound drugs?

<p>Displacement from protein-binding sites (C)</p> Signup and view all the answers

What is a potential consequence of combining epinephrine with cocaine or methamphetamine?

<p>Increased risk of cardiovascular events (A)</p> Signup and view all the answers

What is a difficulty in determining drug-drug interaction risks?

<p>Variability in patient responses (D)</p> Signup and view all the answers

What is the primary mechanism underlying the adverse interaction between benzodiazepines and opioids or antihistamines?

<p>Displacement of benzodiazepines from protein-binding sites, leading to increased free drug concentrations (D)</p> Signup and view all the answers

Which of the following is a common feature of drugs that are highly protein-bound?

<p>High potential for displacement from protein-binding sites (B)</p> Signup and view all the answers

What is the primary risk associated with combining epinephrine with tricyclic antidepressants?

<p>Increased risk of cardiac arrhythmias (A)</p> Signup and view all the answers

Which of the following antibiotics is known to interact with oral contraceptives?

<p>Rifampin (A)</p> Signup and view all the answers

What is the primary mechanism of adverse drug interactions involving NSAIDs and lithium?

<p>Increased reabsorption of lithium in the kidneys, leading to toxicity (C)</p> Signup and view all the answers

Which of the following drugs is frequently involved in adverse drug interactions due to its high protein binding and potential for displacement?

<p>Warfarin (D)</p> Signup and view all the answers

What is the common feature of drugs involved in adverse drug interactions?

<p>High potential for displacement from protein-binding sites or inhibition of metabolic enzymes (C)</p> Signup and view all the answers

What is the common mechanism of adverse drug interactions between epinephrine and tricyclic antidepressants?

<p>Enhanced sympathetic response (D)</p> Signup and view all the answers

Which of the following drugs is most likely to interact with macrolide antibiotics or protease inhibitors due to inhibition of cytochrome P450 enzymes?

<p>Benzodiazepines (D)</p> Signup and view all the answers

What is the primary mechanism underlying the adverse interaction between NSAIDs and lithium?

<p>Increased renal reabsorption (A)</p> Signup and view all the answers

Which of the following drugs is highly protein bound and can displace other highly bound drugs, leading to adverse interactions?

<p>Tricyclic antidepressants (B)</p> Signup and view all the answers

What is the common feature of drugs involved in adverse drug interactions?

<p>Narrow therapeutic index (A)</p> Signup and view all the answers

What is a common mechanism of adverse drug interactions involving macrolide antibiotics?

<p>Inhibition of cytochrome P450 enzymes (A)</p> Signup and view all the answers

What is a potential consequence of combining NSAIDs with low-dose ASA?

<p>Increased risk of gastrointestinal bleeding (C)</p> Signup and view all the answers

What is a characteristic of drugs that interact with tricyclic antidepressants?

<p>Highly protein-bound (D)</p> Signup and view all the answers

What is a mechanism of adverse drug interactions involving highly protein-bound drugs?

<p>Displacement of highly protein-bound drugs (B)</p> Signup and view all the answers

What is a potential consequence of combining epinephrine with cocaine or methamphetamine?

<p>Increased risk of cardiac arrhythmias (A)</p> Signup and view all the answers

What is a difficulty in determining drug-drug interaction risks?

<p>All of the above (D)</p> Signup and view all the answers

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