Adverse Drug Interactions
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Questions and Answers

What adverse drug interaction is associated with tetracycline?

  • Interaction with Warfarin
  • Interaction with alcohol
  • Interaction with oral contraceptives (correct)
  • Interaction with digoxin

    • Which antibiotic is known to interact with Warfarin?

  • Azithromycin
  • Clarithromycin
  • Amoxicillin (correct)
  • Metronidazole

    • What is a potential interaction of metronidazole?

  • Interaction with digoxin
  • Interaction with epinephrine
  • Interaction with lithium (correct)
  • Interaction with benzodiazepines

    • What is a common difficulty in determining drug-drug interaction risks?

    <p>Unknown</p> Signup and view all the answers

    Which drug class is known to interact with SSRIs?

    <p>NSAIDs</p> Signup and view all the answers

    What is a potential interaction of azithromycin or clarithromycin?

    <p>Interaction with digoxin</p> Signup and view all the answers

    What is a mechanism of adverse drug interactions?

    <p>Unknown</p> Signup and view all the answers

    What is the potential consequence of combining epinephrine with tricyclic antidepressants?

    <p>Increased risk of arrhythmias</p> Signup and view all the answers

    Which of the following is a common feature of drugs involved in adverse drug interactions?

    <p>Narrow therapeutic index</p> Signup and view all the answers

    What is the potential consequence of combining benzodiazepines with opioids or antihistamines?

    <p>Increased risk of respiratory depression</p> Signup and view all the answers

    Which of the following drugs is frequently involved in adverse drug interactions due to its high protein binding?

    <p>Warfarin</p> Signup and view all the answers

    What is the potential consequence of combining NSAIDs with lithium?

    <p>Increased lithium toxicity</p> Signup and view all the answers

    Which of the following drugs can displace highly protein-bound drugs, leading to adverse interactions?

    <p>Sulfonamides</p> Signup and view all the answers

    What is the potential consequence of combining clarithromycin with digoxin?

    <p>Increased risk of digoxin toxicity</p> Signup and view all the answers

    What is a potential consequence of combining antibiotics with oral contraceptives?

    <p>Reduced efficacy of the oral contraceptive</p> Signup and view all the answers

    What is a common characteristic of drugs involved in adverse drug interactions?

    <p>High protein binding</p> Signup and view all the answers

    What is a potential interaction of metronidazole with another drug?

    <p>All of the above</p> Signup and view all the answers

    What is a mechanism of adverse drug interactions?

    <p>All of the above</p> Signup and view all the answers

    What is a potential interaction of NSAIDs with another drug?

    <p>All of the above</p> Signup and view all the answers

    What is a difficulty in determining drug-drug interaction risks?

    <p>All of the above</p> Signup and view all the answers

    What is a potential interaction of azithromycin or clarithromycin with another drug?

    <p>Digoxin, increasing the risk of toxicity</p> Signup and view all the answers

    What is a common characteristic of drugs that interact with tricyclic antidepressants?

    <p>High protein binding</p> Signup and view all the answers

    Which class of drugs is known to interact with macrolide antibiotics or protease inhibitors?

    <p>Benzodiazepines</p> Signup and view all the answers

    What is a common mechanism of adverse drug interactions involving highly protein-bound drugs?

    <p>Displacement from protein binding sites</p> Signup and view all the answers

    Which of the following drugs is likely to interact with digoxin?

    <p>Clarithromycin</p> Signup and view all the answers

    What is a common feature of drugs that are highly protein bound?

    <p>Increased risk of adverse drug interactions</p> Signup and view all the answers

    Which of the following drug classes is known to interact with SSRIs?

    <p>Tricyclic antidepressants</p> Signup and view all the answers

    What is a common adverse drug interaction involving NSAIDs?

    <p>Increased risk of lithium toxicity</p> Signup and view all the answers

    What is the primary risk associated with combining epinephrine with tricyclic antidepressants?

    <p>Severe hypertension and cardiac arrhythmias</p> Signup and view all the answers

    Which of the following drug classes is most likely to interact with macrolide antibiotics or protease inhibitors?

    <p>Benzodiazepines</p> Signup and view all the answers

    What is a common feature of drugs involved in adverse drug interactions?

    <p>High protein binding</p> Signup and view all the answers

    Which of the following drugs is highly protein bound and can displace other highly bound drugs, leading to adverse interactions?

    <p>Warfarin</p> Signup and view all the answers

    What is the primary mechanism underlying the adverse interaction between NSAIDs and lithium?

    <p>Displacement from protein binding sites</p> Signup and view all the answers

    Which of the following antibiotics is known to interact with digoxin?

    <p>Clarithromycin</p> Signup and view all the answers

    What is a common characteristic of drugs that interact with tricyclic antidepressants?

    <p>Sympathomimetic effects</p> Signup and view all the answers

    What is a mechanism by which antibiotics can interact with oral contraceptives?

    <p>Altered gut flora, reducing the enterohepatic circulation of the contraceptive</p> Signup and view all the answers

    What is a potential consequence of combining metronidazole with lithium?

    <p>Increased risk of lithium toxicity due to reduced excretion</p> Signup and view all the answers

    What is a characteristic of drugs that are highly protein-bound?

    <p>They are more susceptible to displacement interactions with other drugs</p> Signup and view all the answers

    What is a potential interaction of azithromycin or clarithromycin with digoxin?

    <p>Increased digoxin levels due to inhibition of P-glycoprotein</p> Signup and view all the answers

    What is a common difficulty in determining drug-drug interaction risks?

    <p>Determining the clinical relevance of in vitro interactions</p> Signup and view all the answers

    What is a potential interaction of NSAIDs with ethanol?

    <p>Increased risk of gastrointestinal bleeding</p> Signup and view all the answers

    What is a mechanism of adverse drug interactions involving NSAIDs and SSRIs?

    <p>Increased risk of gastrointestinal bleeding due to synergistic effects</p> Signup and view all the answers

    What is a potential consequence of combining antibiotics with oral contraceptives?

    <p>Decreased efficacy of oral contraceptives</p> Signup and view all the answers

    What is a mechanism by which NSAIDs interact with lithium?

    <p>Decreased reabsorption of lithium in the kidneys</p> Signup and view all the answers

    What is a common characteristic of drugs involved in adverse drug interactions?

    <p>High protein binding</p> Signup and view all the answers

    What is a potential interaction of metronidazole with another drug?

    <p>Increased risk of neurotoxicity with lithium</p> Signup and view all the answers

    What is a mechanism of adverse drug interactions involving highly protein-bound drugs?

    <p>Displacement from protein-binding sites</p> Signup and view all the answers

    What is a potential consequence of combining epinephrine with cocaine or methamphetamine?

    <p>Increased risk of cardiovascular events</p> Signup and view all the answers

    What is a difficulty in determining drug-drug interaction risks?

    <p>Variability in patient responses</p> Signup and view all the answers

    What is the primary mechanism underlying the adverse interaction between benzodiazepines and opioids or antihistamines?

    <p>Displacement of benzodiazepines from protein-binding sites, leading to increased free drug concentrations</p> Signup and view all the answers

    Which of the following is a common feature of drugs that are highly protein-bound?

    <p>High potential for displacement from protein-binding sites</p> Signup and view all the answers

    What is the primary risk associated with combining epinephrine with tricyclic antidepressants?

    <p>Increased risk of cardiac arrhythmias</p> Signup and view all the answers

    Which of the following antibiotics is known to interact with oral contraceptives?

    <p>Rifampin</p> Signup and view all the answers

    What is the primary mechanism of adverse drug interactions involving NSAIDs and lithium?

    <p>Increased reabsorption of lithium in the kidneys, leading to toxicity</p> Signup and view all the answers

    Which of the following drugs is frequently involved in adverse drug interactions due to its high protein binding and potential for displacement?

    <p>Warfarin</p> Signup and view all the answers

    What is the common feature of drugs involved in adverse drug interactions?

    <p>High potential for displacement from protein-binding sites or inhibition of metabolic enzymes</p> Signup and view all the answers

    What is the common mechanism of adverse drug interactions between epinephrine and tricyclic antidepressants?

    <p>Enhanced sympathetic response</p> Signup and view all the answers

    Which of the following drugs is most likely to interact with macrolide antibiotics or protease inhibitors due to inhibition of cytochrome P450 enzymes?

    <p>Benzodiazepines</p> Signup and view all the answers

    What is the primary mechanism underlying the adverse interaction between NSAIDs and lithium?

    <p>Increased renal reabsorption</p> Signup and view all the answers

    Which of the following drugs is highly protein bound and can displace other highly bound drugs, leading to adverse interactions?

    <p>Tricyclic antidepressants</p> Signup and view all the answers

    What is the common feature of drugs involved in adverse drug interactions?

    <p>Narrow therapeutic index</p> Signup and view all the answers

    What is a common mechanism of adverse drug interactions involving macrolide antibiotics?

    <p>Inhibition of cytochrome P450 enzymes</p> Signup and view all the answers

    What is a potential consequence of combining NSAIDs with low-dose ASA?

    <p>Increased risk of gastrointestinal bleeding</p> Signup and view all the answers

    What is a characteristic of drugs that interact with tricyclic antidepressants?

    <p>Highly protein-bound</p> Signup and view all the answers

    What is a mechanism of adverse drug interactions involving highly protein-bound drugs?

    <p>Displacement of highly protein-bound drugs</p> Signup and view all the answers

    What is a potential consequence of combining epinephrine with cocaine or methamphetamine?

    <p>Increased risk of cardiac arrhythmias</p> Signup and view all the answers

    What is a difficulty in determining drug-drug interaction risks?

    <p>All of the above</p> Signup and view all the answers

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