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Questions and Answers
What is the effect of a 4-methyl group on beta lactamases and gram negative bacteria activity?
What is the effect of a 4-methyl group on beta lactamases and gram negative bacteria activity?
- Decreases stability to beta lactamases and activity against gram positive bacteria
- Decreases stability to beta lactamases and activity against gram negative bacteria
- Increases stability to beta lactamases and activity against gram positive bacteria
- Increases stability to beta lactamases and activity against gram negative bacteria (correct)
What is the impact of a 4,4-Gem-dimethyl substitution on antibacterial potency after oral administration?
What is the impact of a 4,4-Gem-dimethyl substitution on antibacterial potency after oral administration?
- Greatly enhances antibacterial potency
- Significantly increases antibacterial potency
- Slightly decreases antibacterial potency (correct)
- Does not affect antibacterial potency
Which penicillin binding protein does Aztreonam preferentially bind to?
Which penicillin binding protein does Aztreonam preferentially bind to?
- PBP-2
- PBP-3 (correct)
- PBP-4
- PBP-1
What is the excretory route of Aztreonam disodium for about 70% of the administered dose?
What is the excretory route of Aztreonam disodium for about 70% of the administered dose?
Which type of infections is Aztreonam primarily used to treat?
Which type of infections is Aztreonam primarily used to treat?
What is the absorption rate of an orally administered dose of Aztreonam?
What is the absorption rate of an orally administered dose of Aztreonam?
What is the main reason meropenem is not used in meningitis?
What is the main reason meropenem is not used in meningitis?
Which bacteria are carbapenems NOT active against?
Which bacteria are carbapenems NOT active against?
What structural feature of carbapenems contributes to their stability against beta-lactamase enzymes?
What structural feature of carbapenems contributes to their stability against beta-lactamase enzymes?
Which carbapenem exhibits a longer half-life due to increased binding to plasma proteins?
Which carbapenem exhibits a longer half-life due to increased binding to plasma proteins?
Which carbapenem is commonly used in combination with cilastatin and now available in a triple-drug product with relebactam?
Which carbapenem is commonly used in combination with cilastatin and now available in a triple-drug product with relebactam?
Which of the following statements about carbapenems is false?
Which of the following statements about carbapenems is false?
Which of the following cephalosporins is NOT active against S.aureus for skin and soft tissue infections?
Which of the following cephalosporins is NOT active against S.aureus for skin and soft tissue infections?
Which antibiotic is effective against Pseudomonas aeruginosa but lacks significant gram-positive activity?
Which antibiotic is effective against Pseudomonas aeruginosa but lacks significant gram-positive activity?
Which cephalosporin is the first orally active, 3rd generation cephalosporin that is not an ester prodrug approved for therapy in the US?
Which cephalosporin is the first orally active, 3rd generation cephalosporin that is not an ester prodrug approved for therapy in the US?
Which cephalosporin has a broad spectrum, resistant to many beta lactamases, and used for respiratory tract infections, otitis media, uncomplicated UTI, and gonorrhea caused by beta lactamase-producing strains?
Which cephalosporin has a broad spectrum, resistant to many beta lactamases, and used for respiratory tract infections, otitis media, uncomplicated UTI, and gonorrhea caused by beta lactamase-producing strains?
Which cephalosporin has broad spectrum activity against both Gram-positive and Gram-negative bacteria and is considered equivalent to ceftriaxone in safety and efficacy?
Which cephalosporin has broad spectrum activity against both Gram-positive and Gram-negative bacteria and is considered equivalent to ceftriaxone in safety and efficacy?
Which antibiotic, when combined with avibactam, extends its spectrum to include Enterobacteriaceae producing AmpC, ESBL, or KPC?
Which antibiotic, when combined with avibactam, extends its spectrum to include Enterobacteriaceae producing AmpC, ESBL, or KPC?
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