Antibiotics Spectrum Quiz

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What is the effect of a 4-methyl group on beta lactamases and gram negative bacteria activity?

Decreases stability to beta lactamases and activity against gram positive bacteria

Decreases stability to beta lactamases and activity against gram negative bacteria

Increases stability to beta lactamases and activity against gram positive bacteria

Increases stability to beta lactamases and activity against gram negative bacteria (correct)

What is the impact of a 4,4-Gem-dimethyl substitution on antibacterial potency after oral administration?

Greatly enhances antibacterial potency

Significantly increases antibacterial potency

Slightly decreases antibacterial potency (correct)

Does not affect antibacterial potency

Which penicillin binding protein does Aztreonam preferentially bind to?

PBP-2

PBP-3 (correct)

PBP-4

PBP-1

What is the excretory route of Aztreonam disodium for about 70% of the administered dose?

Urinary excretion Signup and view all the answers

Which type of infections is Aztreonam primarily used to treat?

Upper and lower respiratory tract infections Signup and view all the answers

What is the absorption rate of an orally administered dose of Aztreonam?

Less than 1% Signup and view all the answers

What is the main reason meropenem is not used in meningitis?

It causes seizures Signup and view all the answers

Which bacteria are carbapenems NOT active against?

Methicillin-resistant staphylococci Signup and view all the answers

What structural feature of carbapenems contributes to their stability against beta-lactamase enzymes?

Inverse stereochemistry at C6 Signup and view all the answers

Which carbapenem exhibits a longer half-life due to increased binding to plasma proteins?

Ertapenem Signup and view all the answers

Which carbapenem is commonly used in combination with cilastatin and now available in a triple-drug product with relebactam?

Ertapenem Signup and view all the answers

Which of the following statements about carbapenems is false?

Doripenem has increased binding to plasma proteins Signup and view all the answers

Which of the following cephalosporins is NOT active against S.aureus for skin and soft tissue infections?

Cefoperazone Signup and view all the answers

Which antibiotic is effective against Pseudomonas aeruginosa but lacks significant gram-positive activity?

Ceftibuten Signup and view all the answers

Which cephalosporin is the first orally active, 3rd generation cephalosporin that is not an ester prodrug approved for therapy in the US?

Cefexime Signup and view all the answers

Which cephalosporin has a broad spectrum, resistant to many beta lactamases, and used for respiratory tract infections, otitis media, uncomplicated UTI, and gonorrhea caused by beta lactamase-producing strains?

Ceftriaxone Signup and view all the answers

Which cephalosporin has broad spectrum activity against both Gram-positive and Gram-negative bacteria and is considered equivalent to ceftriaxone in safety and efficacy?

Cefotaxime Signup and view all the answers

Which antibiotic, when combined with avibactam, extends its spectrum to include Enterobacteriaceae producing AmpC, ESBL, or KPC?

Ceftazidime Signup and view all the answers