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Questions and Answers
Mention two mechanisms by which the Mg2+ block is removed from the channel.
Mention two mechanisms by which the Mg2+ block is removed from the channel.
A change in the transmembrane potential due to Na+ entry and displacement of the Mg2+ ion.
What are the two types of glutamate receptors mentioned in the text?
What are the two types of glutamate receptors mentioned in the text?
AMPA receptor and NMDA receptor.
What are the three classes of metabotropic glutamate receptors?
What are the three classes of metabotropic glutamate receptors?
Group I, Group II, and Group III.
What is the main role of group I metabotropic glutamate receptors?
What is the main role of group I metabotropic glutamate receptors?
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What is the main role of group II and III metabotropic glutamate receptors?
What is the main role of group II and III metabotropic glutamate receptors?
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What is the role of mGluR inhibitors?
What is the role of mGluR inhibitors?
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What is the role of NMDA receptor activation in potentiating signalling via mGluRs?
What is the role of NMDA receptor activation in potentiating signalling via mGluRs?
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What is excitotoxicity?
What is excitotoxicity?
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Name two NMDA receptor antagonists that provide protection in models of ischemia.
Name two NMDA receptor antagonists that provide protection in models of ischemia.
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What is the main inhibitory neurotransmitter in the brain?
What is the main inhibitory neurotransmitter in the brain?
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Who was the first scientist to suggest that the message crosses the synaptic cleft via a chemical compound?
Who was the first scientist to suggest that the message crosses the synaptic cleft via a chemical compound?
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What compound did Henry Dale discover was secreted by fungus ergot and produced effects on organs similar to those produced by nerves?
What compound did Henry Dale discover was secreted by fungus ergot and produced effects on organs similar to those produced by nerves?
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Who devised a method to test Elliott's hypothesis and showed that stimulation of nerves attached to a frog's heart caused the release of chemical substances?
Who devised a method to test Elliott's hypothesis and showed that stimulation of nerves attached to a frog's heart caused the release of chemical substances?
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What did Loewi name the chemical substance he discovered was released by the stimulation of nerves attached to a frog's heart?
What did Loewi name the chemical substance he discovered was released by the stimulation of nerves attached to a frog's heart?
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What year did Loewi and Dale share the Nobel Prize?
What year did Loewi and Dale share the Nobel Prize?
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What is the name of the transporter responsible for storing acetylcholine into synaptic vesicles?
What is the name of the transporter responsible for storing acetylcholine into synaptic vesicles?
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What are the two receptor types that acetylcholine can bind to?
What are the two receptor types that acetylcholine can bind to?
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How many subunits does the nicotinic acetylcholine receptor channel have?
How many subunits does the nicotinic acetylcholine receptor channel have?
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Which subunits are mostly involved in binding acetylcholine in the nicotinic acetylcholine receptor channel?
Which subunits are mostly involved in binding acetylcholine in the nicotinic acetylcholine receptor channel?
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What is the term used for a compound that binds to a receptor and mimics the action of the physiological ligand?
What is the term used for a compound that binds to a receptor and mimics the action of the physiological ligand?
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What is the term used for a compound that binds to a receptor and inhibits the action of the physiological ligand?
What is the term used for a compound that binds to a receptor and inhibits the action of the physiological ligand?
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What is the physiological ligand blocked by the compound mentioned in the text?
What is the physiological ligand blocked by the compound mentioned in the text?
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Which compound is an agonist of the ACh ionotropic receptor?
Which compound is an agonist of the ACh ionotropic receptor?
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Which compound is an antagonist of the ACh ionotropic receptor?
Which compound is an antagonist of the ACh ionotropic receptor?
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How many different subtypes of mAChRs can activate different G proteins?
How many different subtypes of mAChRs can activate different G proteins?
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Which subtypes of mAChRs activate phospholipase C (PLC) via Go or Gq?
Which subtypes of mAChRs activate phospholipase C (PLC) via Go or Gq?
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Which subtypes of mAChRs inhibit adenylate cyclase via Gi and stimulate a K+ channel via Gs?
Which subtypes of mAChRs inhibit adenylate cyclase via Gi and stimulate a K+ channel via Gs?
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Which compound is a fungal alkaloid that binds with high affinity to Muscarinic AChRs?
Which compound is a fungal alkaloid that binds with high affinity to Muscarinic AChRs?
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Which compound can distinguish different subclasses of mAChR?
Which compound can distinguish different subclasses of mAChR?
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Which enzyme degrades acetylcholine in the synaptic cleft?
Which enzyme degrades acetylcholine in the synaptic cleft?
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What is the name of the autoimmune disorder characterized by muscle weakness and a decreased number of functional AChRs?
What is the name of the autoimmune disorder characterized by muscle weakness and a decreased number of functional AChRs?
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