Unraveling the Causes of Obesity

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Questions and Answers

Which of the following factors is believed to be the primary determinant of obesity?

  • Genetics (correct)
  • Environmental factors
  • Physiological factors
  • Psychiatric disorders

Which hormone increases appetite?

  • Melanocyte concentrating hormone
  • Leptin
  • Orexin
  • Ghrelin (correct)

Which part of the brain is referred to as the hunger center?

  • Brain stem
  • Hippocampus
  • Cortex
  • Lateral hypothalamus (correct)

Which hormone is important to the brain's processing of appetite?

<p>GLP-1 (B)</p> Signup and view all the answers

What is the largest determinate of energy expenditure in an individual?

<p>Metabolic rate (A)</p> Signup and view all the answers

What is the definition of Res9ng Energy Expenditure (REE)?

<p>Energy expended by a person at rest (A)</p> Signup and view all the answers

What is the prevalence of Non-Alcoholic FaMy Liver Disease (NAFLD) in obese patients?

<p>80-90% (A)</p> Signup and view all the answers

Which of the following is NOT a medical condition associated with obesity?

<p>Thyroid hormone deficiency (B)</p> Signup and view all the answers

Which neurotransmitters and neuropeptides impact the brain's appetite network?

<p>Orexin and melanocyte concentrating hormone (C)</p> Signup and view all the answers

What is the role of ghrelin in appetite?

<p>It increases appetite (D)</p> Signup and view all the answers

What is the role of leptin in appetite?

<p>It decreases appetite (A)</p> Signup and view all the answers

What is the effect of exogenous leptin in leptin-deficient patients?

<p>It decreases appetite (A)</p> Signup and view all the answers

Which part of the brain is NOT involved in the appetite network?

<p>Frontal cortex (D)</p> Signup and view all the answers

What is the primary determinant of obesity according to the text?

<p>Genetics (A)</p> Signup and view all the answers

What is the role of the lateral hypothalamus in the brain?

<p>It stimulates appetite (B)</p> Signup and view all the answers

What is the effect of growth hormone deficiency on obesity?

<p>It increases obesity (C)</p> Signup and view all the answers

What is the effect of cortisol on obesity?

<p>It increases obesity (C)</p> Signup and view all the answers

Which of the following is NOT a gut hormone important to the brain's processing of appetite?

<p>Insulin (C)</p> Signup and view all the answers

Which of the following stimuli can influence hunger and satiety in humans?

<p>Reward (C)</p> Signup and view all the answers

What is the largest determinate of energy expenditure in an individual?

<p>Metabolic rate (A)</p> Signup and view all the answers

When does the basal metabolic rate (BMR) occur?

<p>4 hours after a meal (C)</p> Signup and view all the answers

What happens to adipose cellularity in obese individuals?

<p>It increases (D)</p> Signup and view all the answers

Which of the following is NOT a risk factor for NAFLD/NASH?

<p>Advanced age (A)</p> Signup and view all the answers

Which of the following is associated with insulin resistance in obese individuals?

<p>Increased glucose uptake by the liver (D)</p> Signup and view all the answers

What is the early indication of cardiac dysfunction associated with obesity and diabetes?

<p>Myocardial remodeling (B)</p> Signup and view all the answers

How is BMI (Body Mass Index) calculated?

<p>Weight (kg) / Height (m) (C)</p> Signup and view all the answers

Which of the following is NOT a phase in the treatment and prevention of obesity?

<p>Quaternary phase (B)</p> Signup and view all the answers

What is the recommended BMI threshold for considering bariatric surgery?

<p>40 (A)</p> Signup and view all the answers

What is the daily energy deficit provided by a lower calorie diet (LCD)?

<p>500-750 kcal (B)</p> Signup and view all the answers

What is the recommended daily calorie intake for men on a lower calorie diet (LCD)?

<p>1500-1800 kcal (A)</p> Signup and view all the answers

What is the recommended daily calorie intake for women on a lower calorie diet (LCD)?

<p>1200-1500 kcal (D)</p> Signup and view all the answers

What is the primary goal of weight management?

<p>To improve weight-related complications (D)</p> Signup and view all the answers

What is the cornerstone of weight management?

<p>Comprehensive lifestyle intervention (A)</p> Signup and view all the answers

Which intervention is considered the most powerful and effective for the treatment of obesity?

<p>Bariatric surgery (A)</p> Signup and view all the answers

Which option is recommended for individuals who do not qualify for bariatric surgery?

<p>Medical devices (C)</p> Signup and view all the answers

When is pharmacologic therapy recommended for weight loss?

<p>When all other interventions have failed (A)</p> Signup and view all the answers

Which drug acts as a lipase inhibitor and induces weight loss by lowering dietary fat absorption?

<p>Orlistat (C)</p> Signup and view all the answers

Which drug combination acts as an appetite suppressant and increases energy expenditure?

<p>Phentermine and Topiramate (C)</p> Signup and view all the answers

Which drug combination works on the hypothalamus and mesolimbic dopamine circuit to reduce cravings?

<p>Naltrexone and Bupropion (C)</p> Signup and view all the answers

Which drug activates the GLP-1 receptor in the brain and regulates appetite and caloric intake?

<p>Liraglutide (D)</p> Signup and view all the answers

Which drug interferes with absorption of fat-soluble vitamins, cyclosporine, levothyroxine, and antiretrovirals?

<p>Orlistat (B)</p> Signup and view all the answers

Which drug combination has contraindications including MAO inhibitor use within 14 days, pregnancy, breastfeeding, hypothyroidism, and glaucoma?

<p>Phentermine and Topiramate (B)</p> Signup and view all the answers

Which drug combination has contraindications including MAO inhibitor use within 14 days, ESRD, uncontrolled HTN, seizure disorder/history, bulimia, and anorexia?

<p>Naltrexone and Bupropion (C)</p> Signup and view all the answers

Which drug has contraindications including pregnancy and personal/family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2?

<p>Liraglutide (B)</p> Signup and view all the answers

Which drug combination has cautionary warnings of suicidality, psychiatric disorder, bipolar disorder, and acute opioid withdrawal?

<p>Naltrexone and Bupropion (A)</p> Signup and view all the answers

Which drug has adverse effects including nausea, diarrhea, constipation, vomiting, abdominal pain, dyspepsia, hypoglycemia, headache, and tachycardia?

<p>Liraglutide (A)</p> Signup and view all the answers

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