Unravel the Secrets of Myocardial Electrophysiology
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Questions and Answers

Which cells in the heart generate force and are connected by intercalated discs?

  • Conduction cells
  • Desmosome cells
  • Sarcomere cells
  • Work cells (correct)
  • What initiates the heartbeat in the heart?

  • Work cells
  • Sinoatrial node (correct)
  • Desmosome cells
  • Conduction cells
  • What is the role of the nerve supply in the heart?

  • To regulate the heartbeat (correct)
  • To generate force
  • To spread electrical events
  • To initiate the heartbeat
  • What drives the beating of the heart?

    <p>Electrical signals generated by the heart itself</p> Signup and view all the answers

    What happens to the heart if it is not provided with oxygen and kept moist?

    <p>The heart gradually slows down and eventually stops.</p> Signup and view all the answers

    Which node in the heart initiates the electrical impulse?

    <p>Sino atrial node (SAN)</p> Signup and view all the answers

    What happens if the SA node is damaged?

    <p>AV node takes over as pacemaker</p> Signup and view all the answers

    What is the main cause of the AV delay in the heart?

    <p>Very few gap junctions</p> Signup and view all the answers

    Which fibers carry the electrical signal to the ventricle muscle cells?

    <p>Purkinje fibers</p> Signup and view all the answers

    Which type of action potential is exhibited by the SA node and AV node?

    <p>Slow response action potential</p> Signup and view all the answers

    Which channels are stimulated during hyperpolarization in slow response cardiac fibers?

    <p>Funny channels</p> Signup and view all the answers

    What is the membrane potential during repolarization in slow response cardiac fibers?

    <p>-70 mV</p> Signup and view all the answers

    What is the main characteristic of the pacemaker potential in slow response cardiac fibers?

    <p>Slow depolarization</p> Signup and view all the answers

    Which node in the heart acts as the fastest pacemaker and can be influenced by the autonomic nervous system?

    <p>SA node</p> Signup and view all the answers

    During phase 0 of the action potential in working cells (ventricular cells), what causes depolarization?

    <p>Opening of Na channels</p> Signup and view all the answers

    What initiates repolarization during phase 1 of the action potential in working cells?

    <p>Closing of Na channels</p> Signup and view all the answers

    What causes the plateau phase during phase 2 of the action potential in working cells?

    <p>Ca influx &gt; K efflux</p> Signup and view all the answers

    What initiates rapid repolarization during phase 3 of the action potential in working cells?

    <p>Opening of delayed K channels</p> Signup and view all the answers

    Which type of muscle contraction requires intracellular support to induce contraction?

    <p>Cardiac muscle contraction</p> Signup and view all the answers

    What is the mechanism by which ryanodine receptors in cardiac muscles are operated?

    <p>Ca binding</p> Signup and view all the answers

    What is the term for the process where the opening of ryanodine receptors allows more Ca in cardiac muscles?

    <p>Calcium induced Calcium release</p> Signup and view all the answers

    What provides 90% of the intracellular Ca in cardiac muscles?

    <p>Intracellular source</p> Signup and view all the answers

    Which type of channel blocker is commonly used to control force of contraction in cardiac muscles?

    <p>L-type Ca+ channel blocker</p> Signup and view all the answers

    Which part of the heart is primarily innervated by the right vagus nerve?

    <p>SA node</p> Signup and view all the answers

    Which part of the heart is primarily innervated by the left vagus nerve?

    <p>AV node</p> Signup and view all the answers

    Which part of the heart is lightly innervated by vagal efferent nerves?

    <p>Ventricular myocardium</p> Signup and view all the answers

    Which receptors are activated by the parasympathetic nervous system in the heart?

    <p>Muscarinic ACh receptors</p> Signup and view all the answers

    Which receptors are activated by the sympathetic nervous system in the heart?

    <p>B1-adrenergic receptors</p> Signup and view all the answers

    What effect does the sympathetic nervous system have on the cardiac excitability of the fast response action potential in cardiac muscle?

    <p>Positive bathmotropic effect</p> Signup and view all the answers

    What effect does the sympathetic nervous system have on the rate and rhythm of the fast response action potential in cardiac muscle?

    <p>Positive chronotropic effect</p> Signup and view all the answers

    What effect does the sympathetic nervous system have on the conduction speed of the fast response action potential in cardiac muscle?

    <p>Positive dromotropic effect</p> Signup and view all the answers

    Which ion is primarily responsible for speeding up the rate of pacemaker depolarization in the presence of sympathetic nervous system activation?

    <p>Na+</p> Signup and view all the answers

    What effect does the parasympathetic nervous system have on the rate of firing of the slow response action potential in cardiac muscle?

    <p>Decreases the rate of firing</p> Signup and view all the answers

    Which channels are inhibited by the parasympathetic nervous system in order to slow down the rate of pacemaker depolarization?

    <p>Ca++ channels</p> Signup and view all the answers

    Why does smoking increase the likelihood of a heart attack?

    <p>It helps atheroma to develop</p> Signup and view all the answers

    Which type of muscle does not tetanize?

    <p>Cardiac muscle</p> Signup and view all the answers

    During which phase of the action potential in working cells does depolarization occur?

    <p>Phase 0</p> Signup and view all the answers

    What is the duration of the absolute refractory period?

    <p>2/3rd part of the cardiac AP</p> Signup and view all the answers

    What happens if a new stimulus occurs during the absolute refractory period?

    <p>It is unable to elicit a new response</p> Signup and view all the answers

    What is the effect of the relative refractory period on the generation of an action potential?

    <p>A stronger stimulus is needed to generate an action potential</p> Signup and view all the answers

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