Questions and Answers
What is the difference between warm and cold AIHA?
Warm AIHA is chronic and caused by IgG, while cold AIHA is acute and caused by IgM and complement.
What is the characteristic feature of neutropenia?
Absolute neutrophil count < 1500 cells/mm3
What can cause eosinopenia?
Cushing syndrome and glucocorticoids
Which condition can cause microangiopathic hemolytic anemia?
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How is warm AIHA treated?
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Study Notes
- Extrinsic hemolytic anemias include autoimmune, drug-induced, microangiopathic, and macroangiopathic types.
- Warm AIHA is a chronic anemia caused by IgG, while cold AIHA is an acute anemia caused by IgM and complement.
- Spherocytes and agglutinated RBCs are seen in warm AIHA, while schistocytes are seen in microangiopathic and macroangiopathic hemolytic anemias.
- Hemolytic anemia can also be caused by infection, such as malaria and Babesia.
- Neutropenia is characterized by an absolute neutrophil count < 1500 cells/mm3 and can be caused by sepsis, drugs, and autoimmune disorders.
- Lymphopenia is characterized by an absolute lymphocyte count < 1500 cells/mm3 and can be caused by HIV, radiation, and sepsis.
- Eosinopenia is characterized by an absolute eosinophil count < 30 cells/mm3 and can be caused by Cushing syndrome and glucocorticoids.
- Glucocorticoids can cause neutrophilia despite causing lymphopenia and eosinopenia.
- Warm AIHA can be treated with steroids, rituximab, and splenectomy, while cold AIHA can be treated with cold avoidance and rituximab.
- Microangiopathic hemolytic anemia can be seen in DIC, TTP/HUS, SLE, HELLP syndrome, and hypertensive emergency.