14 Questions
What is epigenetics?
Alterations in gene expression caused by modifications of the genome and its chromatin components.
What is epigenetics?
Heritable alterations in gene expression encoded by modifications of the genome and its chromatin components
How many genes are encoded in the human genome?
23,000
What are transcription factors?
Proteins that bind to gene promoters and regulate transcription
What are transcription factors?
Proteins that bind to gene promoters and regulate transcription.
How many transcription factors regulate the genes encoded in the human genome?
About 3000
How can the activity of a transcription factor be regulated?
All of the above
What are the four common types of DNA-binding domains?
Helix-turn-helix motif, leucine zipper motif, helix-loop-helix motif, and zinc finger motif
What are the four common types of DNA-binding domains found in transcription factors?
Helix-turn-helix motif, leucine zipper motif, helix-loop-helix motif, and zinc finger motif.
How can the activity of a transcription factor be regulated?
Covalent modification such as phosphorylation
What is the role of micro RNAs (miRNAs) in gene expression?
They regulate post-transcriptional gene expression.
What is the role of micro RNAs (miRNAs) in gene expression?
Regulation of post-transcriptional gene expression
What is the relationship between mutations in the promoter region of genes and carcinogenesis?
Mutations in the promoter region of genes can alter the regulation of gene expression and lead to carcinogenesis.
What is cancer?
A disease of the genome at the cellular level that may be manifested by alterations in gene expression
Study Notes
- Cancer is a disease of the genome at the cellular level that may be manifested by alterations in gene expression.
- Gene expression may be modulated through the regulation of transcription.
- Mutations in the promoter region of genes can alter the regulation of gene expression and lead to carcinogenesis.
- Epigenetics involves heritable alterations in gene expression encoded by modifications of the genome and its chromatin components, but not by changes in the DNA sequence.
- Transcription factors are proteins that bind to gene promoters and regulate transcription.
- There are about 3000 transcription factors that regulate the 23,000 genes encoded in the human genome.
- Transcription factors contain a set of independent protein modules or domains, each having a specific role important for the function of transcription factors.
- Four common types of DNA-binding domains are the helix-turn-helix motif, the leucine zipper motif, the helix-loop-helix motif, and the zinc finger motif.
- The activity of a transcription factor can be regulated by several means, including synthesis in particular cell types only, covalent modification such as phosphorylation, and ligand binding.
- The role of micro RNAs (miRNAs) in the regulation of post-transcriptional gene expression is also presented.
Test your knowledge on gene expression and regulation with this quiz! From the basics of transcription to the role of transcription factors and micro RNAs, this quiz covers topics related to cancer, epigenetics, and more. Challenge yourself with questions on the different types of DNA-binding domains and factors that regulate transcription. Sharpen your understanding of the cellular level of cancer and its genetic manifestations. Don't miss this opportunity to learn and review key concepts in gene expression and regulation.
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