Antidepressants II
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Questions and Answers

Which adverse effect may be associated with MAOIs and can lead to potentially fatal outcomes characterized by occipital headache, palpitations, neck stiffness, nausea, vomiting, and chest pain?

  • Serotonin syndrome
  • Orthostatic hypotension
  • Liver toxicity
  • Hypertensive crisis (correct)

    • Which gastrointestinal effect can be seen with the use of MAOIs?

  • Anorexia (correct)
  • Changes in sexual function
  • Orthostatic hypotension
  • Urinary retention

    • What is a potential drug interaction effect of combining MAOIs with other antidepressants like TCAs and SSRIs?

  • Arrhythmias
  • Orthostatic hypotension
  • Serotonin syndrome (correct)
  • Hypertensive crisis

    • What potential side effect can occur if MAOIs are combined with sympathomimetic drugs like methyldopa?

    <p>Additive hypoglycemic effects</p> Signup and view all the answers

    Which symptom is NOT associated with the potentially fatal hypertensive crisis caused by MAOIs?

    <p>Dry mouth</p> Signup and view all the answers

    Which of the following is a central nervous system side effect that can occur with the use of MAOIs?

    <p>Tremors</p> Signup and view all the answers

    What is an important consideration for starting MAOI therapy after stopping an SSRI in terms of timing?

    <p>Wait for at least 6 weeks</p> Signup and view all the answers

    Which side effects are commonly associated with tricyclic antidepressants (TCAs) but not with selective serotonin reuptake inhibitors (SSRIs)?

    <p>Dry mouth and sedation</p> Signup and view all the answers

    Why have SSRIs largely replaced TCAs and monoamine oxidase inhibitors (MAOIs) in treating depression?

    <p>Because SSRIs are relatively safe even in overdose</p> Signup and view all the answers

    What is the primary therapeutic action of SSRIs in the treatment of depression?

    <p>Blocking the reuptake of serotonin</p> Signup and view all the answers

    What is the minimum time typically required for the full therapeutic effect of SSRIs to be realized?

    <p>4 weeks</p> Signup and view all the answers

    Which of the following is NOT an indication for the use of SSRIs?

    <p>Insomnia</p> Signup and view all the answers

    Why is it important to consider individual patient responses when choosing an SSRI?

    <p>To ensure optimal therapeutic effects</p> Signup and view all the answers

    Which of the following is a common misconception regarding SSRIs?

    <p>Patients will respond the same to any SSRI prescribed</p> Signup and view all the answers

    'University of Baghdad/College of Medicine 2022-2023' provides information about:

    <p><i>A list of SSRIs commonly used</i></p> Signup and view all the answers

    Which neurotransmitters are primarily affected by bupropion?

    <p>Dopamine and norepinephrine</p> Signup and view all the answers

    What is a significant side effect associated with the use of bupropion?

    <p>Increased risk for seizures</p> Signup and view all the answers

    How does mirtazapine primarily affect neurotransmission?

    <p>By serving as an antagonist at presynaptic α2 receptors</p> Signup and view all the answers

    What distinguishes mirtazapine from other antidepressants in terms of side effects?

    <p>Is sedating due to its antihistaminic activity</p> Signup and view all the answers

    Which atypical antidepressant is specifically mentioned for its usefulness in patients trying to quit smoking?

    <p>Bupropion</p> Signup and view all the answers

    What group of agents do atypical antidepressants belong to?

    <p>Mixed group with actions at different sites</p> Signup and view all the answers

    Why should the use of bupropion be avoided in some patients?

    <p>Risk for seizures</p> Signup and view all the answers

    What differentiates bupropion from SSRIs in terms of side effects?

    <p>Has a low incidence of sexual dysfunction</p> Signup and view all the answers

    Which antidepressant is known for its sedating effect and is commonly used for insomnia?

    <p>Trazodone</p> Signup and view all the answers

    What is the main reason behind the sedating effect of Nefazodone and Trazodone?

    <p>Histamine H1 blocking activity</p> Signup and view all the answers

    Which statement about the absorption of SSRIs after oral administration is correct?

    <p>Sertraline absorption is increased by food intake.</p> Signup and view all the answers

    Which antidepressant has been associated with a risk for hepatotoxicity?

    <p>Nefazodone</p> Signup and view all the answers

    What is the main route of excretion for SSRIs?

    <p>Urine</p> Signup and view all the answers

    Why is Vilazodone unique compared to SSRIs?

    <p>5-HT1a partial agonism</p> Signup and view all the answers

    What is the suggested mechanism of action for Vortioxetine in treating depression?

    <p>5-HT1a agonism and 5-HT3/5-HT7 antagonism</p> Signup and view all the answers

    Which SSRIs are potent inhibitors of CYP2D6 isoenzyme?

    <p>Fluoxetine and paroxetine</p> Signup and view all the answers

    Which antidepressant is specifically mentioned to have a risk for priapism?

    <p>Trazodone</p> Signup and view all the answers

    What is a contraindication for the use of SSRIs?

    <p>Allergy to any of the SSRIs</p> Signup and view all the answers

    What contributes to orthostasis and dizziness with Nefazodone and Trazodone use?

    <p>Mild to moderate α1 receptor antagonism</p> Signup and view all the answers

    Why should caution be used with severely depressed or suicidal patients when prescribing SSRIs?

    <p>Risk of increased suicidality</p> Signup and view all the answers

    What should be considered when prescribing SSRIs to pregnant women?

    <p>Benefits to the mother should outweigh potential risks to the fetus</p> Signup and view all the answers

    What is a common adverse effect profile shared by Vilazodone with SSRIs?

    <p>'Discontinuation syndrome' risk if abruptly stopped</p> Signup and view all the answers

    What effect can SSRIs in breast milk have on babies?

    <p>Negative adverse effects on babies</p> Signup and view all the answers

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