37 Questions
What is the main cause of Persistent Mullerian Duct Syndrome (PMDS)?
Mutation in the AMH gene
Which karyotype is most common in True Hermaphrodites?
46XX
What is the primary evaluation test for patients with 46XX DSD?
Ultrasound
Which group classifies True Hermaphrodites into Lateral, Bilateral, and Unilateral types?
Ambiguous genitalia
What is the effect of Androgen Insensitivity Syndrome (AIS) on XY males?
Lack of response to androgens
What is a potential result of Congenital Adrenal Hyperplasia (CAH) in newborns?
Development of ambiguous genitalia
'Leydig Cell Aplasia' is associated with which condition?
Androgen Insensitivity Syndrome (AIS)
Which of the following conditions is associated with defects in testosterone biosynthesis?
Male Pseudohermaphroditism (XY-FEMALE)
Which condition may present with the enzymatic conversion of testosterone to dihydrotestosterone?
Male Pseudohermaphroditism (XY-FEMALE)
What type of defect is commonly associated with Androgen Insensitivity Syndrome (AIS)?
Enzymatic conversion of testosterone to dihydrotestosterone
Which of the following conditions is characterized by Leydig Cell Aplasia?
Congenital Adrenal Hyperplasia (CAH)
What is a common feature of Persistent Mullerian Duct Syndrome?
Defects in androgen-dependent target tissues
Which condition is associated with aberrations in testicular gonadogenesis?
Persistent Mullerian Duct Syndrome
In which condition might you expect to see primary testicular failure?
Androgen Insensitivity Syndrome (AIS)
Which of the following is a cause of Ambiguous Genitalia?
Congenital Adrenal Hyperplasia (CAH)
What is the probable diagnosis for a patient with XY chromosomes but external female genitalia?
Male Pseudohermaphroditism (XY-FEMALE)
Which condition results in a lack of response to male hormones despite having male chromosomes?
Androgen Insensitivity Syndrome (AIS)
Which disorder involves the underdevelopment of male sexual characteristics in an individual with XY chromosomes?
Leydig Cell Aplasia
In which condition do individuals have both ovarian and testicular tissue?
Persistent Mullerian Duct Syndrome
Which disorder involves the overproduction of androgens by the adrenal glands?
Androgen Insensitivity Syndrome (AIS)
'Male Pseudohermaphroditism' refers to individuals with which chromosomal makeup?
XY
Which gene is required for the development of testes in humans?
SRY gene
In Male Pseudohermaphroditism (XY-FEMALE), what is one of the characteristics observed?
Testicular unresponsiveness to hCG & LH
Which condition accounts for the majority of 46XX DSD patients?
Congenital Adrenal Hyperplasia (CAH)
What genetic abnormality is associated with Mixed Gonadal Dysgenesis?
45,X0 / 46,XY
Which gene is affected by inactivating or loss-of-function mutations in Male Pseudohermaphroditism (XY-FEMALE)?
CYP21
In Androgen Insensitivity Syndrome (AIS), what is a common characteristic regarding genitalia?
Incomplete masculinization
What is the most common Disorder of Sex Development (DSD) mentioned in the text?
Male Pseudohermaphroditism (XY-FEMALE)
Which of the following is NOT a potential cause of ambiguous genitalia in newborns?
Excessive exposure to sunlight
What is the main goal of treatment for babies with ambiguous genitalia?
To assign a specific gender
In the context of the text, what does DSD stand for?
Disorder of Sexual Development
What type of surgery may be performed on a baby with ambiguous genitalia to correct an overly large clitoris?
Clitoroplasty
Which tennis player is mentioned in the text as someone who experienced DSD and underwent surgery to be legally recognized as a woman?
Sarah Gronert
What role does hormonal therapy play in the treatment of babies with ambiguous genitalia?
To help assign a specific gender
Which of the following statements is true about ambiguous genitalia?
It may result from hormonal imbalances
'Male pseudohermaphroditism' refers to a condition where an individual has:
XY chromosomes but female external genitalia
'Androgen Insensitivity Syndrome (AIS)' primarily affects individuals with:
Complete insensitivity to androgens
This quiz covers topics related to enzyme defects in testosterone biosynthesis, defects in androgen-dependent target tissues, the enzymatic conversion of testosterone to dihydrotestosterone, and more. Test your knowledge on endocrinology concepts from University of Baghdad's College of Medicine 2022-2023 curriculum.
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