Understanding the Physiological Roles of COX Enzyme
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Questions and Answers

What is the physiological role of COX-1 in the stomach?

  • Reduces the formation of gastric mucosa and promotes peptic ulcer
  • Stimulates gastric acid secretion and decreases gastric blood flow
  • Has no significant role in stomach physiology
  • Inhibits gastric acid secretion and enhances the formation of gastric mucosa (correct)

What is the physiological role of COX-1 in platelets?

  • Has no effect on platelet function
  • Increases platelet aggregation and causes vasoconstriction (correct)
  • Inhibits platelet aggregation and prevents clot formation
  • Promotes bleeding time and clot formation

What is the physiological role of COX-2 in the kidney?

  • Promotes renal vasoconstriction & decreases renal blood flow
  • Important for the maintenance of renal blood flow & normal renal function (correct)
  • Has no significant role in kidney physiology
  • Induces inflammation & impairs renal function

What is the main difference between COX-1 and COX-2?

<p>COX-1 is constitutive while COX-2 is inducible and responsible for inflammation, fever &amp; pain (D)</p> Signup and view all the answers

What are the clinical indications of NSAIDs?

<p>Relieving mild to moderate pain and reducing inflammation (C)</p> Signup and view all the answers

Which enzyme is responsible for maintaining renal blood flow and normal renal function?

<p>COX-2 (D)</p> Signup and view all the answers

What is the physiological role of COX-1 in platelets?

<p>Increases platelet aggregation (B)</p> Signup and view all the answers

What is the primary function of COX-1 in the stomach?

<p>Enhances gastric mucosa formation (C)</p> Signup and view all the answers

Which COX isoenzyme is responsible for inflammation, fever, and pain?

<p>COX-2 (C)</p> Signup and view all the answers

5

<p>NSAIDs are less powerful than opioids but adequate for mild to moderate pain. (B)</p> Signup and view all the answers

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