Understanding the Functions of Pre-BCR in B Cell Maturation
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Questions and Answers

Which cells are called small pre-B cells?

  • Cells that express the μ protein only in the cytoplasm (correct)
  • Cells that express the λ protein on the cell surface
  • Cells that express the μ protein on the cell surface
  • Cells that express the κ protein on the cell surface
  • What is the result of V to J rearrangement of the κ light-chain gene in small pre-B cells?

  • Production of the λ protein and assembly of cell surface IgM
  • Production of the κ protein only in the cytoplasm
  • Production of the κ protein and assembly of cell surface IgM (correct)
  • Production of the μ protein and assembly of cell surface IgM
  • What happens if the rearranged κ chain locus fails to express a functional protein or generates a potentially harmful self-reactive receptor?

  • The κ chain generates a complete antigen receptor
  • The λ light chain is produced
  • The κ chain is eliminated through receptor editing (correct)
  • The μ protein is expressed on the cell surface
  • Which of the following is true about the pre-BCR complex?

    <p>It promotes the survival and proliferation of B lineage cells.</p> Signup and view all the answers

    What happens to pre-B cells that make nonproductive rearrangements at the heavy-chain locus?

    <p>They undergo programmed cell death (apoptosis).</p> Signup and view all the answers

    What is the consequence of mutations in the Btk gene in boys?

    <p>The failure of pre-B cells to survive and the subsequent absence of B cells.</p> Signup and view all the answers

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