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Questions and Answers
Which cells are called small pre-B cells?
Which cells are called small pre-B cells?
- Cells that express the μ protein only in the cytoplasm (correct)
- Cells that express the λ protein on the cell surface
- Cells that express the μ protein on the cell surface
- Cells that express the κ protein on the cell surface
What is the result of V to J rearrangement of the κ light-chain gene in small pre-B cells?
What is the result of V to J rearrangement of the κ light-chain gene in small pre-B cells?
- Production of the λ protein and assembly of cell surface IgM
- Production of the κ protein only in the cytoplasm
- Production of the κ protein and assembly of cell surface IgM (correct)
- Production of the μ protein and assembly of cell surface IgM
What happens if the rearranged κ chain locus fails to express a functional protein or generates a potentially harmful self-reactive receptor?
What happens if the rearranged κ chain locus fails to express a functional protein or generates a potentially harmful self-reactive receptor?
- The κ chain generates a complete antigen receptor
- The λ light chain is produced
- The κ chain is eliminated through receptor editing (correct)
- The μ protein is expressed on the cell surface
Which of the following is true about the pre-BCR complex?
Which of the following is true about the pre-BCR complex?
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What happens to pre-B cells that make nonproductive rearrangements at the heavy-chain locus?
What happens to pre-B cells that make nonproductive rearrangements at the heavy-chain locus?
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What is the consequence of mutations in the Btk gene in boys?
What is the consequence of mutations in the Btk gene in boys?
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