6 Questions
Which cells are called small pre-B cells?
Cells that express the μ protein only in the cytoplasm
What is the result of V to J rearrangement of the κ light-chain gene in small pre-B cells?
Production of the κ protein and assembly of cell surface IgM
What happens if the rearranged κ chain locus fails to express a functional protein or generates a potentially harmful self-reactive receptor?
The κ chain is eliminated through receptor editing
Which of the following is true about the pre-BCR complex?
It promotes the survival and proliferation of B lineage cells.
What happens to pre-B cells that make nonproductive rearrangements at the heavy-chain locus?
They undergo programmed cell death (apoptosis).
What is the consequence of mutations in the Btk gene in boys?
The failure of pre-B cells to survive and the subsequent absence of B cells.
Test your knowledge on the essential functions of the assembled pre-BCR in B cell maturation. Explore the role of the pre-BCR complex in promoting cell survival and proliferation, and its significance as the first checkpoint in B cell development. Learn about the selection and expansion of pre-B cells expressing a functional μ heavy chain.
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