Seizure therapeutics 1
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Questions and Answers

Awareness that a seizure is about to occur _______

prodrome

At least ONE seizure that is not provoked and that can occur again _______

epilepsy

Refractory seizures occur if failure of 2 or more ASMs AND 1 or more seizures per month over _______

18 months

status epilepticus: Continuous seizure lasting _____ or more OR 2 or more seizure without full recovery

<p>5 min</p> Signup and view all the answers

What is the T1 for absense seizures? ______ mins

<p>15</p> Signup and view all the answers

Diazepam rectal gel is a seizure ______ medication.

<p>rescue</p> Signup and view all the answers

Which of the following is NOT a known cause of seizures?

<p>Excessive carbohydrate intake</p> Signup and view all the answers

Prodrome in relation to seizures refers to:

<p><em>Awareness that a seizure is about to occur</em></p> Signup and view all the answers

Which of the following is a negative predictor of discontinuation of anti-seizure medications?

<p>Multiple seizure types in the same person</p> Signup and view all the answers

What is a risk associated with the abrupt withdrawal of anti-seizure medications?

<p>Seizure recurrence</p> Signup and view all the answers

When should carbamazepine (Tegretol) be avoided?

<p>In absence seizures</p> Signup and view all the answers

What is the major active metabolite shared by eslicarbazepine acetate and oxcarbazepine?

<p>Carbamazepine</p> Signup and view all the answers

Which of the following dermatologic risks is associated with eslicarbazepine acetate?

<p>Stevens-Johnson Syndrome</p> Signup and view all the answers

What is the black box warning associated with lamotrigine (Lamictal)?

<p>Risk of serious skin rashes including SJS and TEN</p> Signup and view all the answers

When does SJS and TEN typically develop in patients taking lamotrigine (Lamictal)?

<p>Within 2-8 weeks</p> Signup and view all the answers

What are the warnings and precautions associated with levetiracetam (Keppra) and brivaracetam?

<p>Behavioral and psychiatric disturbances</p> Signup and view all the answers

What is a serious adverse effect associated with carbamazepine (Tegretol)?

<p>Agranulocytosis</p> Signup and view all the answers

Why should carbamazepine (Tegretol) be taken with food?

<p>To decrease stomach upset</p> Signup and view all the answers

Which of the following is true about carbazepine ?

<p>It can induce its own metabolism</p> Signup and view all the answers

What should be closely monitored in patients taking oxcarbazepine (Trileptal)?

<p>CMP levels</p> Signup and view all the answers

Which statement is true regarding the risk of hyponatremia between carbamazepine (Tegretol) and oxcarbazepine (Trileptal)?

<p><strong>Hyponatremia</strong> is more common with oxcarbazepine (Trileptal)</p> Signup and view all the answers

Which medication significantly decreases lamotrigine serum concentrations?

<p>Oral contraceptions</p> Signup and view all the answers

What is not an AE associated with valproate (Depakote) ?

<p>Weight loss</p> Signup and view all the answers

When is the typical timeframe for the development of serious skin rashes, including SJS and TEN, with lamotrigine (Lamictal)?

<p>2-8 weeks</p> Signup and view all the answers

Which of the following is a specific warning/precaution for levetiracetam (Keppra) and brivaracetam?

<p>Potential behavioral and psychiatric disturbances</p> Signup and view all the answers

Which drug DOES NOT require renal dose adjustments?

<p>Lamotrigine</p> Signup and view all the answers

What is the schedule classification of brivaracetam?

<p>CV</p> Signup and view all the answers

What is a common first-line agent for focal seziures according to the text?

<p>Levetiracetam (Keppra)</p> Signup and view all the answers

Which medication is most commonly used in the treatment of neuropathic pain?

<p>Gabapentin</p> Signup and view all the answers

Which is not a Boxed warning for Valproate?

<p>New onset aggression and psychiatric disturbances</p> Signup and view all the answers

Valproate is contraindicated in ____ ____?

<p>Mitochondrial Disorders</p> Signup and view all the answers

Valproate Therapeutic Range

<p>50-125 mcg/ml</p> Signup and view all the answers

IV use of Brivaracetam is limited to ___ consecutive days

<p>4</p> Signup and view all the answers

What is a contraindication for phenytoin and fosphenytoin?

<p>Sinus bradychardia</p> Signup and view all the answers

Match the drug with the Box warning

<p>Phenytoin = CV risk rapid infusion Perampanel = psychiatric and behavioral disturbances Felbamate = Aplastic Anemia Valproate = Pancreatits</p> Signup and view all the answers

Felbamate should be discontinued if ___ are 2x normal upper limit normal

<p>LFTs</p> Signup and view all the answers

Which drug is an NMDA-R blocker

<p>Felbamate</p> Signup and view all the answers

T/F: Pentobarbital is a GABA-A Pam that increases channel opening time

<p>True</p> Signup and view all the answers

Primidone is metablized by CYP____ into Phentobarbital and PEMA

<p>CYP2C9</p> Signup and view all the answers

Which ASM is NOT contraindicated in Familial Short QT syndrome

<p>Epidolex</p> Signup and view all the answers

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