Seizure therapeutics 1

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Awareness that a seizure is about to occur _______

prodrome

At least ONE seizure that is not provoked and that can occur again _______

epilepsy

Refractory seizures occur if failure of 2 or more ASMs AND 1 or more seizures per month over _______

18 months

status epilepticus: Continuous seizure lasting _____ or more OR 2 or more seizure without full recovery

5 min Signup and view all the answers

What is the T1 for absense seizures? ______ mins

15 Signup and view all the answers

Diazepam rectal gel is a seizure ______ medication.

rescue Signup and view all the answers

Which of the following is NOT a known cause of seizures?

Excessive carbohydrate intake Signup and view all the answers

Prodrome in relation to seizures refers to:

Awareness that a seizure is about to occur Signup and view all the answers

Which of the following is a negative predictor of discontinuation of anti-seizure medications?

Multiple seizure types in the same person Signup and view all the answers

What is a risk associated with the abrupt withdrawal of anti-seizure medications?

Seizure recurrence Signup and view all the answers

When should carbamazepine (Tegretol) be avoided?

In absence seizures Signup and view all the answers

What is the major active metabolite shared by eslicarbazepine acetate and oxcarbazepine?

Carbamazepine Signup and view all the answers

Which of the following dermatologic risks is associated with eslicarbazepine acetate?

Stevens-Johnson Syndrome Signup and view all the answers

What is the black box warning associated with lamotrigine (Lamictal)?

Risk of serious skin rashes including SJS and TEN Signup and view all the answers

When does SJS and TEN typically develop in patients taking lamotrigine (Lamictal)?

Within 2-8 weeks Signup and view all the answers

What are the warnings and precautions associated with levetiracetam (Keppra) and brivaracetam?

Behavioral and psychiatric disturbances Signup and view all the answers

What is a serious adverse effect associated with carbamazepine (Tegretol)?

Agranulocytosis Signup and view all the answers

Why should carbamazepine (Tegretol) be taken with food?

To decrease stomach upset Signup and view all the answers

Which of the following is true about carbazepine ?

It can induce its own metabolism Signup and view all the answers

What should be closely monitored in patients taking oxcarbazepine (Trileptal)?

CMP levels Signup and view all the answers

Which statement is true regarding the risk of hyponatremia between carbamazepine (Tegretol) and oxcarbazepine (Trileptal)?

Hyponatremia is more common with oxcarbazepine (Trileptal) Signup and view all the answers

Which medication significantly decreases lamotrigine serum concentrations?

Oral contraceptions Signup and view all the answers

What is not an AE associated with valproate (Depakote) ?

Weight loss Signup and view all the answers

When is the typical timeframe for the development of serious skin rashes, including SJS and TEN, with lamotrigine (Lamictal)?

2-8 weeks Signup and view all the answers

Which of the following is a specific warning/precaution for levetiracetam (Keppra) and brivaracetam?

Potential behavioral and psychiatric disturbances Signup and view all the answers

Which drug DOES NOT require renal dose adjustments?

Lamotrigine Signup and view all the answers

What is the schedule classification of brivaracetam?

CV Signup and view all the answers

What is a common first-line agent for focal seziures according to the text?

Levetiracetam (Keppra) Signup and view all the answers

Which medication is most commonly used in the treatment of neuropathic pain?

Gabapentin Signup and view all the answers

Which is not a Boxed warning for Valproate?

New onset aggression and psychiatric disturbances Signup and view all the answers

Valproate is contraindicated in ?

Mitochondrial Disorders Signup and view all the answers

Valproate Therapeutic Range

50-125 mcg/ml Signup and view all the answers

IV use of Brivaracetam is limited to ___ consecutive days

4 Signup and view all the answers

What is a contraindication for phenytoin and fosphenytoin?

Sinus bradychardia Signup and view all the answers

Match the drug with the Box warning

Phenytoin = CV risk rapid infusion Perampanel = psychiatric and behavioral disturbances Felbamate = Aplastic Anemia Valproate = Pancreatits Signup and view all the answers