65 Questions
What are pathogenic microorganisms or pathogens capable of ?
Causing disease in any individual
What are antimicrobials
Chemicals or natural compounds that help kill or prevent growth of microorganisms
What are antimicrobials able to perform
Function as an antibiotic depending on certain factors, but can also function as antiviral, antifungal, and antiparasitic
Coccobacilli are organisms that can look like both cocci and bacilli
True
Gram-stain method/test is a technique used to clarify bacteria into two groups, gram-positive and gram -egative
True
What is an indication of antibiotic success other than zone of inhibition
Minimum in hibitory concentration
As per the book, antibiotics can cause which of the following
Nephrotoxicity and hepatotoxicity
Because some antibiotics can cause nephrotoxicity and hepatotoxicity, what should be monitored
Blood values and clinical symptoms
Instructions regarding withdrawal time should be followed to ensure that the drug will be cleared from the animals body. Otherwise the remainder of the drug, known as __________________, can contaminate meat and dairy products which can lead to antibiotic resistance or even allergic reactions in humans
Antibiotic residue
Inhibition of cell wall synthesis works by:
Attacking the cell walls of the bacteria and prevents the synthesis of peptidoglycan
B Lactam drugs inhibit bacterial cell wall ________
Synthesis
Penicillins can be classified as first-, second-, third-, and fourth generation. The first-generation have a broad spectrum and are effective against gram-positive and negative organisms, while the later generations have a more narrow spectrum and are primarily effective against one type of bacteria.
False
Penicillins can be classified as first-, second-, third-, and fourth generation. The laters generations have a broad spectrum and are effective against both gram-positive and negative organisms, while the first-generation have a more narrow spectrum and are primarily effective against one type of bacteria.
True
By combining certain antimicrobials with another drug that is a B-lactamase inhibitor resistance can be avoided. What are some common B-lactam drugs ?
Penicillins and Cephalosporins
Penicillin can be used to treat various infections, such as soft tissue, urinary tract and general bacteria infections, they can also fight internal and external infections, However what are 3 things that penicillins cannot easily cross or enter?
BBB, prostate and eyeball
Used for UTI, soft tissue infections, pneumonia and other infections. Comes in capsule, injectable, oral solution and tablets. The most common side effect is diarrhea and vomiting.
Amoxicillin
Used for skin and urinary tract infections, infected wounds and respiratory infections, comes in oral, suspension and tablets. Not well absorbed by large animals
Amoxicillin + clavulanate potassium
Used for skin, soft tissue and urinary tract infections as well as pneumonia. Comes in capsule and injectable. Anaphylaxis can occur when given IV
Ampicillin
Used for general bacterial infections, pneumonia and sepsis, and comes as an injectable. Addition of secondary drug provides a broader spectrum and makes it more effective against B-lactamase producing bacteria
Ampicillin + sulbactam
Used for gram-positive cocci respiratory infections, UTIs or abscecess . Comes in injectable or tablet. Pain and tissue reaction are commonly noted when given SQ or IM. Should NEVER be given IV due to severe and potentially fatal reaction
Penicillin G
Large group of antibiotics similar to penicillins and are also used to treat bacterial infections. They kill bacteria directly and can prevent bacterial growth. They are often seen as an alternative to penicillins because they can be more effective at killing certain bacteria
Cephalosporins
Used for surgical prophylaxis, skin and soft tissue infections and UTIs. Comes as an injectable
Cefazolin sodium/ancef
Used for skin/soft tissue infections or UTIs. Comes as an injectable
Cefovecin/convenia
Used on skin and soft tissue infections, comes as an oral suspension or tablet
Cefpodoxime proxetil/simplicef
Used for various infections in cattle, swine and horses. Comes as an injectable
Ceftiofur sodim/naxcel
Bacteria have a cell membrane that separates and protects the cells internal structure from the outside environment. Which of the following is an antibiotic that increases permeability of the bacterial cell membrane, causing it to take up water, which will ultimately kill the bacteria
Polymixin B
Drugs that _________________ prevent certain molecules from binding to selected sites on ribosomes (ribosomes are the site of protein synthesis)
Inhibit protein synthesis
Common drugs used to inhibit protein synthesis
Any/All of the above
This class is most commonly administered parenterally because they are not well absorbed in the GI tract, if IV administration is selected, the patient must be well hydrated.
Aminoglycosides
This class of antibiotics is often combined with penicillins and cephalosporins for greater efficacy, however, they are ineffective in the presence of organic material like pus or necrotic tissue
Aminoglycosides
This class of antiobiotics are bacteriostatic that penetrate most body tissues and fluids and are used to treat both systemic and local infections
Tetracyclines
Aminoglycoside commonly used for gram-negative bacterial infections,injectable form
Both A and C
Aminoglycoside that is generally used for gram-negative bacterial infections and swine dysentery. Comes as an injectable and oral solution for swine
Gentamicin sulfate/Gentacin
Which of the following is not true of tetracyclines
None of the above
Causes defects in tooth and bone formation in tooth and bone formation in young animals. This class should not be used eith dairy products because they affect absorption (durg binds to calcium)
Tetracyclines
Which tetracycline is commonly used for tick borne and bacterial diseases and comes in a capsule, injectable, oral suspension or tablet
Doxycycline /Monodox,Vibramicin
Tetracycline commonly used for respiratory , urinary, skin, and soft tissue infections, common forms are bolus, injectables, powder and tablet
Oxytetracycline
Tetracycline that is commonly used for soft tissue infections, UTIs and pneumonia. Common forms are bolus, capsule, oral suspension and powder
Tetracycline
This class of antibiotics are bacteriostatic and inhibit the growth of bacteria, often prescribed to treat a wide variety of common bacterial infections. They should be used eith caution in hindgut fermenters and ruminants because the can cause a fatal enterotoxemia. May also cause potentially fatal diarrhea in horses and potential thrombophlebitis if given intravenously
Macrolides
IV solution of this macrolide can be stored at room temperature for 48 hours after reconstitution and can be a good choice for patients with penicillin and cephalosporin allergies
Azithromycin/Zithromax
Macrolide commonly used to treat various bacterial infections, particularly gram-positive, comes in capsule, injectable, oral suspension and tablet
Azithromycin
This macrolide can cause diarrhea in large animals
Erythromycin
This macrolide is commonly used to treat respiratory, skin infections and stimulation of intestinal motility
Erythromycin
Horses have had fatal reactions to this macrolide, administration is contraindicated
None of the above
Macrolide commonly used for bovine respiratory disease, cattle foot rot, swine erysepelas, and swine dysentery . Common forms are feed additive, injectable, and soluble powder
Tylosin
This class of drug can be bactericidal or bacteriostatic depending on the concentration. Particularly effective against gram-positive bacteria, especially staphylococci and streptococci
Lincosamides
Lincosamide that can cause esophageal lesions in cats because of its irritating nature. Commonly used for gram-positive anaerobic bacterial infections of skin, mouth and respiratory tract.
Clindamycin hydrochloride
This class is a broad spectrum antibiotic, primarily bacteriostatic, can cause blood abnormalities and bone marrow suppression and should be avoided or used with caution in animals with preexisting blood disorders, prohibited in use on food animals
Chloramphenicols
Precautions must be taken by humans when handling this class of drugs because it can cause permanent damage of the bone marrow like aplastic anemia
Chloramphenicols
This class interferes with bacterial production of folic acid, which is critical for bacterial metabolism. Works against many different gram-neg and pos bacteria.
Sulfonamides
Dobermans, miniature schnauzers and samoyeds seem to have increased sensitivity to this class of drug. Adverse effects in general include KCS, crystaluria, bone marrow suppression and skin rashes
Chloramphenicols
Sulfonamide that commonly treats pneumonia, skin infections, UTIs and soft tissue infections, common form is tablets
Ormetoprim + sulfadimethoxine/Primor
Sulfonamide commonly used for intestinal injections, soft tissue infections, UTIs and commonly comes in injectable form, tablet, and oral suspension
Sulfadimethoxine/Albon
Sulfonamide commonly used to treat various bacterial infections in dogs, cats, horses and exotics, common forms are injectables, powder and tablet
Ttrimethoprim + sulfadiazine
Used for UTIs, skin and soft tissue infections in dogs, cats, horses and exotics, comes as an injectable, oral suspension, and tablet
Trimethoprim + sulfamethoxazole
This class prevents DNA replication or inhibit RNA synthesis, effective towards a wide variety of gram neg and pos bacteria, often used to treat resp and UTI
Fluoroquinolones
Adverse effects of this class includes blidness or retinopathy in cats and increased risk for tendonitis and ruptured tendons, neurotoxicity, renal toxicity and cartilage damage particularly in young/growing animals. Not all drugs in this class are approved for food animals
Fluoroquinolones
Fluoroquinolone used for skin and soft tissue infections, respiratory infections, and bovine respiratory disease, DO NOT use in young animals because of potential for cartilage damage and CNS toxicity
Enrofloxacin/Baytril
Fluoroquinolone used for bacterial infections in dogs and cats. DO NOT use in young animals because of potential for cartilage damage and CNS toxicity
Marbofloxacin/Zeniquin
Fluoroquinolone often used for skin and soft tissue infections, UTIs in dogs, cats, and horses. DO NOT use in young animals due to potential for cartilage damage and CNS toxicity
Orbifloxacin/Orbax
Inhibition of cell wall synthesis
Penicillins, Cephalosporins
Damage to cell membrane
Polymixin B
Interference of metabolism
Sulfonamides
Impairment of nucleic acids (DNA and RNA)
Fluoroquinolones
Inhibition of protein synthesis
Macrolides, Aminoglycosides, Lincosamide, Tetracyclines, Chloramphenicol
Study Notes
Pathogenic Microorganisms
- Capable of causing disease or infection
Antimicrobials
- Capable of killing or inhibiting microorganisms
- Perform various functions, including:
- Inhibiting cell wall synthesis
- Inhibiting protein synthesis
- Increasing permeability of bacterial cell membrane
Bacterial Classification
- Coccobacilli: organisms that can resemble both cocci and bacilli
- Gram-stain method: classifies bacteria into two groups, gram-positive and gram-negative
Antibiotics
- Can cause nephrotoxicity and hepatotoxicity, requiring monitoring of kidney and liver function
- Can cause antibiotic resistance or allergic reactions in humans if not used properly
- Inhibition of cell wall synthesis: works by preventing bacterial cell wall formation
B-Lactam Drugs
- Inhibit bacterial cell wall synthesis
- Examples include:
- Penicillins
- Cephalosporins
- Combined with B-lactamase inhibitors to avoid resistance
Penicillins
- Classified into four generations:
- First-generation: broad spectrum, effective against gram-positive and gram-negative organisms
- Later generations: narrower spectrum, effective against specific types of bacteria
- Used to treat various infections, including:
- Soft tissue infections
- Urinary tract infections
- General bacterial infections
- Cannot easily cross or enter:
- Blood-brain barrier
- Eye tissue
- Prostate gland
Other Antibiotics
- Cephalosporins: used for skin and urinary tract infections, infected wounds, and respiratory infections
- Macrolides: used to treat bacterial infections, including respiratory, skin, and soft tissue infections
- Aminoglycosides: used to treat gram-negative bacterial infections, including:
- Gentamicin
- Neomycin
- Tetracyclines: used to treat bacterial infections, including:
- Doxycycline
- Oxytetracycline
- Chlortetracycline
- Lincosamides: used to treat gram-positive anaerobic bacterial infections
- Sulfonamides: used to treat bacterial infections, including:
- Sulfamethoxazole
- Sulfadimethoxine
- Fluoroquinolones: used to treat bacterial infections, including:
- Ciprofloxacin
- Enrofloxacin
- Orbifloxacin
Test your knowledge of pathogenic microorganisms, also known as pathogens, and their capabilities. Learn about the different types of microorganisms and how they affect human health.
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