Podcast
Questions and Answers
What is the core feature of obesity?
What is the core feature of obesity?
Chronic energy imbalance
How does chronic low-grade inflammation in obesity affect metabolic health?
How does chronic low-grade inflammation in obesity affect metabolic health?
It can lead to insulin resistance, dyslipidemia, and hypertension.
What are the factors that can influence susceptibility to obesity?
What are the factors that can influence susceptibility to obesity?
Genetic predisposition, environmental factors
Name two obesity-related complications other than type 2 diabetes and cardiovascular disease.
Name two obesity-related complications other than type 2 diabetes and cardiovascular disease.
What are some lifestyle modifications used in managing obesity?
What are some lifestyle modifications used in managing obesity?
How do excess FFAs contribute to inflammation in adipocytes and macrophages?
How do excess FFAs contribute to inflammation in adipocytes and macrophages?
What role do adipokines like adiponectin and leptin play in obesity-related inflammation?
What role do adipokines like adiponectin and leptin play in obesity-related inflammation?
How does dysregulated lipid metabolism in obesity lead to ectopic lipid deposition?
How does dysregulated lipid metabolism in obesity lead to ectopic lipid deposition?
What impact does intracellular lipid accumulation have on insulin signaling pathways in target tissues?
What impact does intracellular lipid accumulation have on insulin signaling pathways in target tissues?
How does lipid-induced inflammation in the liver affect insulin action?
How does lipid-induced inflammation in the liver affect insulin action?
What are the two pro-inflammatory cytokines increased in obesity that activate inflammatory signaling pathways?
What are the two pro-inflammatory cytokines increased in obesity that activate inflammatory signaling pathways?
What is the consequence of excessive lipid accumulation in the liver due to obesity?
What is the consequence of excessive lipid accumulation in the liver due to obesity?
How does lipid-induced insulin resistance in skeletal muscle affect glucose uptake?
How does lipid-induced insulin resistance in skeletal muscle affect glucose uptake?
Which adipokines are mentioned to antagonize insulin action in obesity?
Which adipokines are mentioned to antagonize insulin action in obesity?
How does obesity contribute to dysregulated appetite regulation and energy balance?
How does obesity contribute to dysregulated appetite regulation and energy balance?
What are the key features of obesity-related complications?
What are the key features of obesity-related complications?
How does obesity contribute to hepatic steatosis?
How does obesity contribute to hepatic steatosis?
What is the impact of intramyocellular lipids on insulin signaling pathways?
What is the impact of intramyocellular lipids on insulin signaling pathways?
How does lipid accumulation in beta cells contribute to impaired insulin secretion?
How does lipid accumulation in beta cells contribute to impaired insulin secretion?
What role does adipose tissue inflammation play in systemic insulin resistance?
What role does adipose tissue inflammation play in systemic insulin resistance?
