Understanding Mutagens and DNA Repair Mechanisms
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Questions and Answers

Which type of mutagen directly impacts bases resulting in depurination or loss of a purine?

  • Alkylators (correct)
  • Gamma radiation
  • UV radiation
  • Human papillomavirus (HPV)

What is the main cause of the condition xeroderma pigmentosum?

  • Lack of an enzyme needed to remove thymine dimers from DNA sequences (correct)
  • Increased exposure to ultraviolet radiation
  • Presence of nitrous acid in the environment
  • Mutation due to biological mutagens

Which virus is associated with long-term infections that can lead to cancer in the reproductive tract?

  • Helicobacter pylori
  • Human papillomavirus (HPV) (correct)
  • Epstein Barr virus
  • Hepatitis B virus

What effect does nitrosoguanidine have on DNA?

<p>Results in depurination and base mispairing (A)</p> Signup and view all the answers

How do mutagens primarily create damage to DNA?

<p>By replacing normal DNA polymerase with Y-family polymerases (C)</p> Signup and view all the answers

During which stage of the cell cycle does base excision repair remove a damaged base from the DNA?

<p>G1 (A)</p> Signup and view all the answers

Which repair mechanism occurs in both the G1 and G2 stages of the cell cycle to delete lesions on nucleotide sequences in DNA?

<p>Nucleotide excision repair (D)</p> Signup and view all the answers

What is the primary role of mismatch repair in DNA replication?

<p>Maintaining base pair matching within the DNA (B)</p> Signup and view all the answers

Which of the following is NOT an example of a physical mutagen?

<p>Viruses (B)</p> Signup and view all the answers

What type of biological agents are capable of initiating changes in an individual's DNA?

<p>Viruses and bacteria (C)</p> Signup and view all the answers

What is the primary effect of alkylation in DNA?

<p>Addition of alkyl groups to bases, leading to increased DNA mutations (D)</p> Signup and view all the answers

Which of the following mutations can have a beneficial effect on human health?

<p>Mutations that reduce the risk of neurodegenerative disorders like Parkinson's disease (B)</p> Signup and view all the answers

What is the primary role of mutations in the process of evolution?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is NOT a specific action of mutagens on DNA?

<p>Replication leading to the formation of new DNA strands (D)</p> Signup and view all the answers

What is the effect of coordination by heavy metal ions on DNA?

<p>Crosslinking of DNA, blocking replication, repair, and transcription (C)</p> Signup and view all the answers

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