Understanding Minimal Effective Concentration of Antibiotics
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Questions and Answers

What does the minimal effective concentration (MEC) of an antibiotic refer to?

  • The serum drug level that broadens the spectrum of the drug
  • The serum drug level that increases the therapeutic index
  • The serum drug level that is sufficient to halt the growth of the microorganism (correct)
  • The serum drug level that ensures the drug is bacteriostatic

What is the most likely cause of a patient's infection not responding to an antibiotic that has been used successfully several times before?

  • Cross-resistance
  • Inherent bacterial resistance
  • Transferred resistance
  • Acquired bacterial resistance (correct)

A patient has previously experienced a severe rash when taking penicillin. What action should the nurse take when preparing to administer amoxicillin to this patient?

  • Contact the provider to discuss using a different antibiotic (correct)
  • Administer the amoxicillin and have epinephrine available
  • Request an order for a beta-lactamase-resistant drug
  • Ask the provider to order an antihistamine

A patient has been receiving an antibiotic for 2 days after a culture was obtained. What is the nurse's understanding of this situation?

<p>The patient's culture results have not yet been received, but the antibiotic is appropriate (B)</p> Signup and view all the answers

Which of the following statements best describes the concept of cross-resistance in relation to antibiotics?

<p>Cross-resistance occurs when a microorganism becomes resistant to an antibiotic due to its resistance to a different antibiotic (B)</p> Signup and view all the answers

What is the most likely reason for a patient's infection not responding to an antibiotic that has been successfully used before?

<p>The patient's infection has become resistant to the antibiotic (D)</p> Signup and view all the answers

What is the nurse's next best action based on the patient's increased erythema, swelling, and persistent high fever?

<p>Review the sensitivity results from the patient's culture. (D)</p> Signup and view all the answers

Which action is most important before administering the first dose of an antibiotic to a patient admitted for a urinary tract infection?

<p>Obtaining a urine specimen for culture and sensitivity. (C)</p> Signup and view all the answers

Which antibiotic will the nurse expect the provider to order for a patient admitted with pneumonia who was unable to produce sputum for a culture?

<p>A broad-spectrum antibiotic. (A)</p> Signup and view all the answers

Which statement by the nurse is correct when teaching a patient who will be discharged home from the hospital to take amoxicillin twice daily for ten days?

<p>&quot;Stop taking the drug and notify your provider if you develop a rash while taking this drug.&quot; (C)</p> Signup and view all the answers

What is the nurse's next action when reviewing the patient's chart and noting that the patient previously experienced a rash when taking amoxicillin, before administering the first dose of intravenous ceftriaxone?

<p>Administer the drug and observe closely for hypersensitivity reactions. (D)</p> Signup and view all the answers

Which action will the nurse take when preparing to give a dose of cephalosporin medication to a patient who has received the antibiotic for two weeks and the nurse notes ulcers on the patient's tongue and buccal mucosa?

<p>Report a possible side effect of the cephalosporin, such as superinfection. (A)</p> Signup and view all the answers

Which statement by the patient indicates a need for further teaching when the nurse is providing teaching to a patient who will begin taking cephalosporin to treat an infection?

<p>&quot;I may stop taking the medication if my symptoms clear up.&quot; (D)</p> Signup and view all the answers

What is the most important reason for obtaining a urine specimen for culture and sensitivity before starting antibiotic therapy for a urinary tract infection?

<p>To determine the appropriate antibiotic treatment. (B)</p> Signup and view all the answers

Why is a broad-spectrum antibiotic frequently used to treat pneumonia when the offending organism is not identified by culture and sensitivity?

<p>To target a wider range of potential bacterial pathogens. (A)</p> Signup and view all the answers

What is the nurse's primary concern when a patient reports developing a rash while taking amoxicillin?

<p>The patient may have a hypersensitivity reaction to the medication. (B)</p> Signup and view all the answers

If a patient develops a rash while taking an antibiotic, the nurse should instruct them to:

<p>Stop taking the drug and call their provider (C)</p> Signup and view all the answers

Which of the following foods should a patient avoid while taking amoxicillin?

<p>Acidic fruits and juices (C)</p> Signup and view all the answers

If a nurse notices that a penicillin G procaine solution has a milky color, what action should they take?

<p>Administer the medication as ordered by the physician (D)</p> Signup and view all the answers

If a patient is taking azithromycin for an exacerbation of chronic bronchitis and also takes digoxin and warfarin, the nurse should expect:

<p>Increased effectiveness of digoxin (B)</p> Signup and view all the answers

If a patient reports having had a rash when taking penicillin, the nurse should contact the provider to:

<p>Discuss using erythromycin instead of penicillin (D)</p> Signup and view all the answers

If a patient is receiving a high dose of intravenous azithromycin and also taking acetaminophen, which lab values should the nurse monitor for side effects?

<p>Liver enzymes (A)</p> Signup and view all the answers

Which of the following actions does NOT contribute to bacterial resistance to antibiotics?

<p>Taking a full course of antibiotics as prescribed (B)</p> Signup and view all the answers

If a patient is taking penicillin and reports having had a rash in the past, the nurse should NOT:

<p>Administer the penicillin as ordered by the physician (B)</p> Signup and view all the answers

Which of the following foods is safe for a patient to consume while taking amoxicillin?

<p>Green salad (D)</p> Signup and view all the answers

According to the instructions, when should antacids be taken in relation to azithromycin?

<p>2 hours before or 2 hours after taking azithromycin (B)</p> Signup and view all the answers

Why should azithromycin be taken 1 hour before or 2 hours after meals?

<p>Azithromycin is poorly absorbed when taken with food (C)</p> Signup and view all the answers

If a patient experiences watery diarrhea while taking azithromycin, what should they do?

<p>Report it immediately, as it may indicate pseudomembranous colitis (C)</p> Signup and view all the answers

If a patient is taking warfarin and needs to start clarithromycin, what action should the nurse take?

<p>Request an order for INR testing (B)</p> Signup and view all the answers

Which macrolide order should the nurse question for a patient who is allergic to penicillin and plans to take fluconazole?

<p>Erythromycin (B)</p> Signup and view all the answers

Why are serum drug peak and trough levels necessary for certain drugs?

<p>For drugs with a narrow therapeutic index (C)</p> Signup and view all the answers

If a patient's serum drug trough level is below the normal range, what can the nurse expect?

<p>Inadequate therapeutic effects (C)</p> Signup and view all the answers

When should doxycycline be taken in relation to meals?

<p>With food to improve absorption (B)</p> Signup and view all the answers

What is the recommended timing for taking antacids in relation to tetracyclines?

<p>Antacids should be avoided while taking tetracyclines (D)</p> Signup and view all the answers

Why might a high tetracycline dose be prescribed?

<p>To achieve a higher peak level for therapeutic effect (C)</p> Signup and view all the answers

Which laboratory values should the nurse monitor for a patient receiving high doses of tetracycline?

<p>Blood urea nitrogen (BUN) and creatinine levels (D)</p> Signup and view all the answers

What advice should the nurse give to a patient taking oral contraceptives while being prescribed doxycycline?

<p>Use a backup method of contraception (B)</p> Signup and view all the answers

If an infant receiving intravenous gentamicin has not had a wet diaper for several hours, what should the nurse do?

<p>Hold the dose and contact the provider for a serum trough drug level (D)</p> Signup and view all the answers

A 70-kg patient receiving gentamicin reports ringing in the ears. What should the nurse discuss with the provider?

<p>Obtaining a serum drug level to check for toxicity (A)</p> Signup and view all the answers

When administering intravenous ampicillin and gentamicin, what is an important nursing action?

<p>Set up separate tubing sets for each drug labeled with name and date (A)</p> Signup and view all the answers

If a patient's serum gentamicin peak level is 9 mcg/mL and trough level is 2 mcg/mL, what action should the nurse take?

<p>Report possible drug toxicity to the provider (C)</p> Signup and view all the answers

Which statement about administering intravenous gentamicin is correct?

<p>It should be infused over 30-60 minutes (C)</p> Signup and view all the answers

What is a potential adverse effect of gentamicin that the nurse should monitor for?

<p>Nephrotoxicity (B)</p> Signup and view all the answers

When administering intravenous ampicillin and gentamicin, what action should the nurse take to prevent mixing the drugs?

<p>Flush the line with saline between each drug (D)</p> Signup and view all the answers

What should the nurse do if a patient reports ringing in the ears while receiving gentamicin?

<p>Notify the provider and discuss obtaining a serum drug level (D)</p> Signup and view all the answers

According to the concept of minimal effective concentration (MEC) of antibiotics, which statement indicates the nursing student's understanding?

<p>A serum drug level greater than the MEC is sufficient to halt the growth of the microorganism. (A)</p> Signup and view all the answers

What is the most likely cause of a patient's infection not responding to an antibiotic that has been used successfully several times before?

<p>Acquired bacterial resistance (D)</p> Signup and view all the answers

If a patient previously experienced a severe rash when taking penicillin, what action should the nurse take when preparing to administer amoxicillin?

<p>Contact the provider to discuss using a different antibiotic. (D)</p> Signup and view all the answers

If a patient has been receiving an antibiotic for 2 days after a culture was obtained, what is the nurse's understanding of this situation?

<p>The antibiotic is being used empirically before culture results are available. (A)</p> Signup and view all the answers

Which statement about administering intravenous gentamicin is correct?

<p>If a patient reports ringing in the ears while receiving gentamicin, the nurse should discuss the concern with the provider. (C)</p> Signup and view all the answers

Which of the following foods should a patient avoid while taking amoxicillin?

<p>Dairy products (A)</p> Signup and view all the answers

Which statement by the patient indicates an understanding of the teaching regarding azithromycin?

<p>I may take antacids 2 hours before taking this drug. (B)</p> Signup and view all the answers

When the nurse learns that a patient taking warfarin will begin taking clarithromycin, which action should the nurse take?

<p>Request an order for INR testing. (D)</p> Signup and view all the answers

Which macrolide order would the nurse question for a patient allergic to penicillin who plans to take fluconazole?

<p>Erythromycin (B)</p> Signup and view all the answers

For which type of drug are serum drug peak and trough levels necessary?

<p>Drugs with a narrow therapeutic index (A)</p> Signup and view all the answers

If a patient's serum drug trough is below the normal range, what will the nurse expect the patient to experience?

<p>Inadequate therapeutic effects (A)</p> Signup and view all the answers

How should the nurse plan to give doxycycline to a patient?

<p>With food to improve absorption (B)</p> Signup and view all the answers

Which statement by the nurse is correct when teaching a patient who will be discharged home from the hospital to take amoxicillin twice daily for ten days?

<p>All of the above (D)</p> Signup and view all the answers

What is the most likely reason for a patient's infection not responding to an antibiotic that has been successfully used before?

<p>Antibiotic resistance (B)</p> Signup and view all the answers

If a patient is taking azithromycin for an exacerbation of chronic bronchitis and also takes digoxin and warfarin, the nurse should expect:

<p>Increased risk of bleeding (A)</p> Signup and view all the answers

Which antibiotic will the nurse expect the provider to order for a patient admitted with pneumonia who was unable to produce sputum for a culture?

<p>Azithromycin (B)</p> Signup and view all the answers

What should a patient do if they develop a rash while taking an antibiotic?

<p>Stop taking the drug and notify the provider (A)</p> Signup and view all the answers

Which of the following foods should a patient avoid while being treated with amoxicillin?

<p>Acidic fruits and juices (C)</p> Signup and view all the answers

What is the appearance of Penicillin G procaine and how should a nurse respond to it?

<p>Yellow solution; administer as ordered (D)</p> Signup and view all the answers

What effect can azithromycin have on the effectiveness of digoxin and warfarin?

<p>Increased effectiveness of digoxin (B)</p> Signup and view all the answers

If a patient has had a rash when taking penicillin, what alternative drug may be used?

<p>Erythromycin instead of penicillin (B)</p> Signup and view all the answers

Which lab values should be monitored when a patient is taking high doses of intravenous azithromycin along with acetaminophen?

<p>Liver enzymes (D)</p> Signup and view all the answers

Which laboratory values will the nurse expect to monitor while caring for a patient receiving high doses of tetracycline?

<p>Blood urea nitrogen (BUN) and creatinine levels (D)</p> Signup and view all the answers

When teaching a female patient about taking doxycycline to treat a sexually transmitted infection (STI), what important information should the nurse include?

<p>Use a backup method of contraception if taking oral contraceptives. (A)</p> Signup and view all the answers

If an infant receiving intravenous gentamicin has not had a wet diaper for several hours, what should the nurse do?

<p>Hold the dose and contact the provider to request a serum trough drug level. (B)</p> Signup and view all the answers

A 70-kg patient is receiving gentamicin 85 mg 4 times daily and reports experiencing ringing in the ears. What should the nurse discuss with the provider?

<p>Obtaining a serum drug level (A)</p> Signup and view all the answers

When preparing to administer intravenous ampicillin and gentamicin to a patient, what is an important nursing action?

<p>Set up separate tubing sets for each drug labeled with the drug name and date. (C)</p> Signup and view all the answers

The nurse reviews a patient's chart and notes that the last serum peak gentamicin level was 9 mcg/mL and the last trough level was 2 mcg/mL. What action should the nurse take?

<p>Obtain repeat peak and trough levels before giving the next dose. (D)</p> Signup and view all the answers

Which of the following is the most likely cause of a patient's infection not responding to an antibiotic that has been used successfully several times before?

<p>Antibiotic resistance (A)</p> Signup and view all the answers

What is a potential adverse effect of gentamicin that the nurse should monitor for?

<p>Ototoxicity (D)</p> Signup and view all the answers

Why might a high tetracycline dose be prescribed?

<p>To treat a severe bacterial infection (A)</p> Signup and view all the answers

If a patient's serum gentamicin trough level is below the normal range, what can the nurse expect?

<p>Decreased therapeutic effect (B)</p> Signup and view all the answers

What is the nurse's best action when preparing to give a dose of cephalosporin medication to a patient who has received the antibiotic for two weeks and the nurse notes ulcers on the patient's tongue and buccal mucosa?

<p>Hold the drug and notify the provider (A)</p> Signup and view all the answers

What is the most important reason for obtaining a urine specimen for culture and sensitivity before starting antibiotic therapy for a urinary tract infection?

<p>To identify the organism causing the infection (B)</p> Signup and view all the answers

Which statement by the patient indicates a need for further teaching when the nurse is providing instructions to a patient who will begin taking cephalosporin to treat an infection?

<p>&quot;I should avoid food rich in vitamin C while on this medication.&quot; (D)</p> Signup and view all the answers

What should the nurse do if a patient reports ringing in the ears while receiving gentamicin?

<p>Continue administering the medication as prescribed (C)</p> Signup and view all the answers

Which action will the nurse take when reviewing the patient's chart and noting that the patient previously experienced a rash when taking amoxicillin, before administering the first dose of intravenous ceftriaxone?

<p>Administer the drug and observe closely for hypersensitivity reactions (B)</p> Signup and view all the answers

Why is a broad-spectrum antibiotic frequently used to treat pneumonia when the offending organism is not identified by culture and sensitivity?

<p>To ensure rapid treatment without waiting for culture results (B)</p> Signup and view all the answers

What should a patient do if diarrhea occurs while taking amoxicillin?

<p>Stop taking the drug immediately and contact the provider (A)</p> Signup and view all the answers

What is the nurse's next action based on the patient's increased erythema, swelling, and persistent high fever?

<p>Review sensitivity results from the patient's culture (C)</p> Signup and view all the answers

Which intervention is most important before administering an antibiotic to a patient admitted for a urinary tract infection?

<p>Obtaining a urine specimen for culture and sensitivity (D)</p> Signup and view all the answers

What will the nurse expect if a patient admitted for pneumonia could not produce sputum for culture?

<p>A broad-spectrum antibiotic to be given (D)</p> Signup and view all the answers

What is the minimal effective concentration (MEC) of antibiotics primarily responsible for?

<p>Halting the growth of microorganisms (C)</p> Signup and view all the answers

Why might a patient's current urinary tract infection not respond to an antibiotic that was previously effective?

<p>Acquired bacterial resistance (A)</p> Signup and view all the answers

What action should a nurse take when a patient with a history of penicillin allergy needs to take amoxicillin?

<p>Discuss using a different antibiotic with the provider (C)</p> Signup and view all the answers

What should be the nurse's understanding when preparing to administer an antibiotic after 2 days of culture-based treatment?

<p>Resistance to the antibiotic may have developed (D)</p> Signup and view all the answers

Which laboratory values will the nurse expect to monitor while caring for a patient receiving high doses of tetracycline?

<p>Blood urea nitrogen (BUN) and creatinine levels (D)</p> Signup and view all the answers

When teaching a female patient about taking doxycycline for a sexually transmitted infection, what information will the nurse include?

<p>Use a backup method of contraception if taking oral contraceptives. (A)</p> Signup and view all the answers

If an infant receiving intravenous gentamicin has not had a wet diaper for several hours, what should the nurse do?

<p>Hold the dose and contact the provider to request a serum trough drug level. (C)</p> Signup and view all the answers

A 70-kg patient is receiving gentamicin 85 mg 4 times daily and reports experiencing ringing in the ears. What should the nurse discuss with the provider?

<p>Obtaining a serum drug level (D)</p> Signup and view all the answers

When preparing to administer intravenous ampicillin and gentamicin to a patient, what is an important nursing action?

<p>Set up separate tubing sets for each drug labeled with the drug name and date. (A)</p> Signup and view all the answers

The nurse reviews a patient's chart and notes that the last serum peak gentamicin level was 9 mcg/mL and the last trough level was 2 mcg/mL. What action should the nurse take?

<p>Obtain repeat peak and trough levels before giving the next dose. (A)</p> Signup and view all the answers

If a patient is taking azithromycin for an exacerbation of chronic bronchitis and also takes digoxin and warfarin, the nurse should expect:

<p>Increased risk of digoxin and warfarin toxicity. (B)</p> Signup and view all the answers

Which statement by the patient indicates a need for further teaching when the nurse is providing instructions to a patient who will begin taking cephalosporin to treat an infection?

<p>I should take the medication with food to avoid stomach upset. (D)</p> Signup and view all the answers

If a patient has been receiving an antibiotic for 2 days after a culture was obtained, what is the nurse's understanding of this situation?

<p>The antibiotic is being used empirically while awaiting culture results. (A)</p> Signup and view all the answers

What is the most important reason for obtaining a urine specimen for culture and sensitivity before starting antibiotic therapy for a urinary tract infection?

<p>To identify the causative organism. (C)</p> Signup and view all the answers

A patient is prescribed azithromycin and reports developing watery diarrhea while taking it. What should the patient do?

<p>Report the diarrhea to the healthcare provider immediately (B)</p> Signup and view all the answers

A patient taking warfarin is prescribed clarithromycin. What action should the nurse take?

<p>Request an order for INR testing (C)</p> Signup and view all the answers

A patient allergic to penicillin is prescribed erythromycin and plans to take fluconazole for a potential yeast infection. What should the nurse question?

<p>The concurrent use of erythromycin and fluconazole (D)</p> Signup and view all the answers

Why are serum drug peak and trough levels necessary for certain antibiotics?

<p>To monitor antibiotics with a narrow therapeutic index (B)</p> Signup and view all the answers

If a patient's serum drug trough level is below the normal range, what can the nurse expect?

<p>Inadequate therapeutic effects (A)</p> Signup and view all the answers

When should doxycycline, a tetracycline antibiotic, be taken in relation to meals?

<p>With food to improve absorption (B)</p> Signup and view all the answers

If a patient reports ringing in the ears while receiving gentamicin, what should the nurse discuss with the provider?

<p>Discontinuing gentamicin due to potential ototoxicity (B)</p> Signup and view all the answers

A patient is prescribed azithromycin and plans to take antacids for heartburn. When should the antacids be taken in relation to azithromycin?

<p>2 hours before taking azithromycin (C)</p> Signup and view all the answers

What is the most likely cause of a patient's infection not responding to an antibiotic that has been used successfully before?

<p>The causative organism has developed resistance to the antibiotic (C)</p> Signup and view all the answers

When administering intravenous ampicillin and gentamicin, what action should the nurse take to prevent mixing the drugs?

<p>All of the above (D)</p> Signup and view all the answers

What is the appropriate action if a patient develops a rash while taking an antibiotic?

<p>Stop taking the drug and notify the provider (A)</p> Signup and view all the answers

Which food should a patient avoid while being treated with amoxicillin?

<p>Acidic fruits and juices (B)</p> Signup and view all the answers

What should the nurse do if penicillin G procaine appears milky in color?

<p>Administer the medication as ordered by the physician (C)</p> Signup and view all the answers

What effect can azithromycin have on digoxin and warfarin when taken together?

<p>Increased effectiveness of digoxin (D)</p> Signup and view all the answers

If a patient has previously experienced a rash with penicillin, what is the preferred alternative drug?

<p>Using erythromycin instead of penicillin (C)</p> Signup and view all the answers

When should antibiotics be stopped if a rash develops?

<p>As soon as the rash appears (B)</p> Signup and view all the answers

What is the nurse's next best action based on the patient's increased erythema, swelling, and persistent high fever?

<p>Review the sensitivity results from the patient's culture. (B)</p> Signup and view all the answers

Which action is most important before administering the first dose of an antibiotic to a patient admitted for a urinary tract infection?

<p>Obtaining a urine specimen for culture and sensitivity. (B)</p> Signup and view all the answers

Why is a broad-spectrum antibiotic frequently used to treat pneumonia when the offending organism is not identified by culture and sensitivity?

<p>Broad-spectrum antibiotics are effective against a wide range of organisms, including those that may not be detected by culture. (A)</p> Signup and view all the answers

Which statement by the patient indicates a need for further teaching when the nurse is providing teaching to a patient who will begin taking cephalosporin to treat an infection?

<p>&quot;I should eat yogurt while taking this medication.&quot; (C)</p> Signup and view all the answers

What action will the nurse take when preparing to give a dose of cephalosporin medication to a patient who has received the antibiotic for two weeks and the nurse notes ulcers on the patient's tongue and buccal mucosa?

<p>Report a possible side effect of the cephalosporin, such as superinfection. (D)</p> Signup and view all the answers

What is the most important reason for obtaining a urine specimen for culture and sensitivity before starting antibiotic therapy for a urinary tract infection?

<p>To correctly identify the organism and help determine which antibiotic will be most effective. (C)</p> Signup and view all the answers

If a patient has had a rash when taking penicillin, what alternative drug may be used?

<p>Ceftriaxone (B)</p> Signup and view all the answers

What should the nurse do if a patient reports ringing in the ears while receiving gentamicin?

<p>Notify the provider and suggest an oral cephalosporin. (B)</p> Signup and view all the answers

Which laboratory values will the nurse expect to monitor while caring for a patient receiving high doses of tetracycline?

<p>Liver function tests (B)</p> Signup and view all the answers

What is the appearance of Penicillin G procaine and how should a nurse respond to it?

<p>Penicillin G procaine is a cloudy solution, and the nurse should not administer it and should notify the provider. (B)</p> Signup and view all the answers

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