Understanding Humoral Immunity
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Questions and Answers

Which molecule is recognised by antigen-specific armed T helper cells?

  • IL-4
  • Peptide:MHC complex (correct)
  • CD30
  • CD40 ligand
  • Which molecule binds to CD40 on B cells to help drive the resting B cell into the cell cycle and increase expression of co-stimulatory molecules?

  • 41BB
  • CD30
  • IL-4
  • CD40 ligand (correct)
  • Which cytokine induces B cell proliferation?

  • IL-4 (correct)
  • IL-5
  • IL-6
  • CD30
  • Which antibody is the principal isotype in blood and extracellular fluid?

    <p>IgG</p> Signup and view all the answers

    Which antibody is found in secretions such as intestine and respiratory tract?

    <p>IgA</p> Signup and view all the answers

    Which antibody tends to have low affinity and is found in blood and lymphs?

    <p>IgM</p> Signup and view all the answers

    Which antibody can neutralize bacterial toxins?

    <p>IgG and IgA</p> Signup and view all the answers

    Which pathway is activated when antibody:antigen complexes bind to C1q?

    <p>Classical complement pathway</p> Signup and view all the answers

    Which cells are triggered to release stored mediators when Fc receptors are engaged?

    <p>NK cells, mast cells, basophils</p> Signup and view all the answers

    Which cells can be activated to respond based on the isotype of the antibody?

    <p>Different cell types bear Fc receptors for antibodies of different isotypes</p> Signup and view all the answers

    Which process involves antibodies binding to infected cells expressing pathogen proteins on their surface, leading to their killing by natural killer (NK) cells?

    <p>Antibody-dependent cell-mediated cytotoxicity (ADCC)</p> Signup and view all the answers

    What is the main effector function of B cells?

    <p>Production of immunoglobulins</p> Signup and view all the answers

    What determines the specificity of immunoglobulins?

    <p>Hypervariable regions</p> Signup and view all the answers

    In what way do antibodies contribute to immunity?

    <p>Activation of B cells by T helper cells</p> Signup and view all the answers

    Where are antibodies usually produced?

    <p>Activated B cells (plasma cells)</p> Signup and view all the answers

    What is the role of the B cell receptor (BCR) in B cell activation?

    <p>Transmits a signal inside the cell when it binds antigen</p> Signup and view all the answers

    Where do most bacteria multiply?

    <p>Extracellular spaces</p> Signup and view all the answers

    How do antibodies contribute to immunity against intracellular pathogens?

    <p>Requires Th2 cells</p> Signup and view all the answers

    What do hypervariable regions of antibodies make contact with?

    <p>Antigen</p> Signup and view all the answers

    What is the difference between antibodies raised against intact proteins and peptide fragments?

    <p>Binding characteristics</p> Signup and view all the answers

    What is the main function of immunoglobulins on the B cell surface?

    <p>Act as the cell's receptor for antigen</p> Signup and view all the answers

    How do antibodies usually bind to intact proteins?

    <p>Surface binding</p> Signup and view all the answers

    What is the specificity of antibodies determined by?

    <p>Complementarity-determining regions</p> Signup and view all the answers

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