Understanding Humoral Immunity
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Questions and Answers

Which molecule is recognised by antigen-specific armed T helper cells?

  • IL-4
  • Peptide:MHC complex (correct)
  • CD30
  • CD40 ligand

Which molecule binds to CD40 on B cells to help drive the resting B cell into the cell cycle and increase expression of co-stimulatory molecules?

  • 41BB
  • CD30
  • IL-4
  • CD40 ligand (correct)

Which cytokine induces B cell proliferation?

  • IL-4 (correct)
  • IL-5
  • IL-6
  • CD30

Which antibody is the principal isotype in blood and extracellular fluid?

<p>IgG (A)</p> Signup and view all the answers

Which antibody is found in secretions such as intestine and respiratory tract?

<p>IgA (D)</p> Signup and view all the answers

Which antibody tends to have low affinity and is found in blood and lymphs?

<p>IgM (B)</p> Signup and view all the answers

Which antibody can neutralize bacterial toxins?

<p>IgG and IgA (C)</p> Signup and view all the answers

Which pathway is activated when antibody:antigen complexes bind to C1q?

<p>Classical complement pathway (B)</p> Signup and view all the answers

Which cells are triggered to release stored mediators when Fc receptors are engaged?

<p>NK cells, mast cells, basophils (A)</p> Signup and view all the answers

Which cells can be activated to respond based on the isotype of the antibody?

<p>Different cell types bear Fc receptors for antibodies of different isotypes (D)</p> Signup and view all the answers

Which process involves antibodies binding to infected cells expressing pathogen proteins on their surface, leading to their killing by natural killer (NK) cells?

<p>Antibody-dependent cell-mediated cytotoxicity (ADCC) (A)</p> Signup and view all the answers

What is the main effector function of B cells?

<p>Production of immunoglobulins (B)</p> Signup and view all the answers

What determines the specificity of immunoglobulins?

<p>Hypervariable regions (B)</p> Signup and view all the answers

In what way do antibodies contribute to immunity?

<p>Activation of B cells by T helper cells (A)</p> Signup and view all the answers

Where are antibodies usually produced?

<p>Activated B cells (plasma cells) (B)</p> Signup and view all the answers

What is the role of the B cell receptor (BCR) in B cell activation?

<p>Transmits a signal inside the cell when it binds antigen (B)</p> Signup and view all the answers

Where do most bacteria multiply?

<p>Extracellular spaces (C)</p> Signup and view all the answers

How do antibodies contribute to immunity against intracellular pathogens?

<p>Requires Th2 cells (D)</p> Signup and view all the answers

What do hypervariable regions of antibodies make contact with?

<p>Antigen (C)</p> Signup and view all the answers

What is the difference between antibodies raised against intact proteins and peptide fragments?

<p>Binding characteristics (C)</p> Signup and view all the answers

What is the main function of immunoglobulins on the B cell surface?

<p>Act as the cell's receptor for antigen (A)</p> Signup and view all the answers

How do antibodies usually bind to intact proteins?

<p>Surface binding (A)</p> Signup and view all the answers

What is the specificity of antibodies determined by?

<p>Complementarity-determining regions (B)</p> Signup and view all the answers

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