23 Questions
Which molecule is recognised by antigen-specific armed T helper cells?
Peptide:MHC complex
Which molecule binds to CD40 on B cells to help drive the resting B cell into the cell cycle and increase expression of co-stimulatory molecules?
CD40 ligand
Which cytokine induces B cell proliferation?
IL-4
Which antibody is the principal isotype in blood and extracellular fluid?
IgG
Which antibody is found in secretions such as intestine and respiratory tract?
IgA
Which antibody tends to have low affinity and is found in blood and lymphs?
IgM
Which antibody can neutralize bacterial toxins?
IgG and IgA
Which pathway is activated when antibody:antigen complexes bind to C1q?
Classical complement pathway
Which cells are triggered to release stored mediators when Fc receptors are engaged?
NK cells, mast cells, basophils
Which cells can be activated to respond based on the isotype of the antibody?
Different cell types bear Fc receptors for antibodies of different isotypes
Which process involves antibodies binding to infected cells expressing pathogen proteins on their surface, leading to their killing by natural killer (NK) cells?
Antibody-dependent cell-mediated cytotoxicity (ADCC)
What is the main effector function of B cells?
Production of immunoglobulins
What determines the specificity of immunoglobulins?
Hypervariable regions
In what way do antibodies contribute to immunity?
Activation of B cells by T helper cells
Where are antibodies usually produced?
Activated B cells (plasma cells)
What is the role of the B cell receptor (BCR) in B cell activation?
Transmits a signal inside the cell when it binds antigen
Where do most bacteria multiply?
Extracellular spaces
How do antibodies contribute to immunity against intracellular pathogens?
Requires Th2 cells
What do hypervariable regions of antibodies make contact with?
Antigen
What is the difference between antibodies raised against intact proteins and peptide fragments?
Binding characteristics
What is the main function of immunoglobulins on the B cell surface?
Act as the cell's receptor for antigen
How do antibodies usually bind to intact proteins?
Surface binding
What is the specificity of antibodies determined by?
Complementarity-determining regions
Test your knowledge of humoral immunity and B cell antigen recognition with this quiz. Explore the role of immunoglobulins (Ig) and the B cell receptor (BCR) in recognizing antigens.
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