5.2 Understanding HSV-2 Infection: Viral Shedding

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Questions and Answers

What is the recommended timing for administering HSV-2 vaccine?

Before the first sexual contact

What is the most useful setting for administering HSV vaccines?

Low to middle income countries (LMIC)

What are the two kinds of vaccines that could be developed to manage HSV?

Prophylactic vaccine and Therapeutic vaccine

What are the advantages of a prophylactic vaccine for genital herpes?

Reduces burden of disease (BoD) and reduces HIV acquisition risk Signup and view all the answers

What are some candidates already in clinical development for genital herpes vaccine?

BioNTech mRNA, Moderna mRNA, GSK Recombinant protein Signup and view all the answers

How many known herpes viruses are known and how many are clinically relevant

100 known and 8 relevant Signup and view all the answers

what is Hsv capable of

capable of infecting nerve ganglia and preventing viral clearence by the immune system = latancy Signup and view all the answers

What are the WHO preferred product characteristics for herpes simplex virus vaccines?

Large clinical trials (>10000 participants), pediatric population, potential impact on symptoms and transmission, and no existing immunization platforms Signup and view all the answers

What distinguishes a therapeutic HSV vaccine from a prophylactic vaccine?

Therapeutic HSV vaccines are given to treat genital herpes signs and symptoms, while prophylactic vaccines are given to prevent infection before exposure to the virus. Signup and view all the answers

What are the advantages and disadvantages of prophylactic vaccines for genital herpes?

Advantages: Reduces burden of disease, reduces HIV acquisition risk, and has the greatest impact in low to middle income countries (LMIC). Disadvantages: Potentially only impact on symptoms but not on transmission, and potentially no impact on HIV acquisition. Signup and view all the answers

what is a key determinant of transmission

Viral shredding Signup and view all the answers

What is the most suitable timing for administering HSV-1 vaccine?

during infancy Signup and view all the answers

What is the primary focus of therapeutic HSV vaccines?

to treat genital herpes signs and symptoms Signup and view all the answers

What distinguishes a therapeutic HSV vaccine from a prophylactic vaccine?

Therapeutic HSV vaccines are given to treat genital herpes signs and symptoms, while prophylactic vaccines are given to prevent infection. Signup and view all the answers

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