14 Questions
What is the recommended timing for administering HSV-2 vaccine?
Before the first sexual contact
What is the most useful setting for administering HSV vaccines?
Low to middle income countries (LMIC)
What are the two kinds of vaccines that could be developed to manage HSV?
Prophylactic vaccine and Therapeutic vaccine
What are the advantages of a prophylactic vaccine for genital herpes?
Reduces burden of disease (BoD) and reduces HIV acquisition risk
What are some candidates already in clinical development for genital herpes vaccine?
BioNTech mRNA, Moderna mRNA, GSK Recombinant protein
How many known herpes viruses are known and how many are clinically relevant
100 known and 8 relevant
what is Hsv capable of
capable of infecting nerve ganglia and preventing viral clearence by the immune system = latancy
What are the WHO preferred product characteristics for herpes simplex virus vaccines?
Large clinical trials (>10000 participants), pediatric population, potential impact on symptoms and transmission, and no existing immunization platforms
What distinguishes a therapeutic HSV vaccine from a prophylactic vaccine?
Therapeutic HSV vaccines are given to treat genital herpes signs and symptoms, while prophylactic vaccines are given to prevent infection before exposure to the virus.
What are the advantages and disadvantages of prophylactic vaccines for genital herpes?
Advantages: Reduces burden of disease, reduces HIV acquisition risk, and has the greatest impact in low to middle income countries (LMIC). Disadvantages: Potentially only impact on symptoms but not on transmission, and potentially no impact on HIV acquisition.
what is a key determinant of transmission
Viral shredding
What is the most suitable timing for administering HSV-1 vaccine?
during infancy
What is the primary focus of therapeutic HSV vaccines?
to treat genital herpes signs and symptoms
What distinguishes a therapeutic HSV vaccine from a prophylactic vaccine?
Therapeutic HSV vaccines are given to treat genital herpes signs and symptoms, while prophylactic vaccines are given to prevent infection.
This quiz will test your knowledge about the natural history of HSV-2 infection, particularly focusing on viral shedding. Questions will cover the frequency of shedding, symptomatic and asymptomatic shedding, and the impact of unawareness of infection on transmission rates.
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