5.2 Understanding HSV-2 Infection: Viral Shedding

Before the first sexual contact

Low to middle income countries (LMIC)

Prophylactic vaccine and Therapeutic vaccine

<p>Reduces burden of disease (BoD) and reduces HIV acquisition risk</p> Signup and view all the answers

<p>BioNTech mRNA, Moderna mRNA, GSK Recombinant protein</p> Signup and view all the answers

<p>100 known and 8 relevant</p> Signup and view all the answers

<p>capable of infecting nerve ganglia and preventing viral clearence by the immune system = latancy</p> Signup and view all the answers

<p>Large clinical trials (&gt;10000 participants), pediatric population, potential impact on symptoms and transmission, and no existing immunization platforms</p> Signup and view all the answers

<p>Therapeutic HSV vaccines are given to treat genital herpes signs and symptoms, while prophylactic vaccines are given to prevent infection before exposure to the virus.</p> Signup and view all the answers

<p>Advantages: Reduces burden of disease, reduces HIV acquisition risk, and has the greatest impact in low to middle income countries (LMIC). Disadvantages: Potentially only impact on symptoms but not on transmission, and potentially no impact on HIV acquisition.</p> Signup and view all the answers

<p>Viral shredding</p> Signup and view all the answers

<p>during infancy</p> Signup and view all the answers

<p>to treat genital herpes signs and symptoms</p> Signup and view all the answers

<p>Therapeutic HSV vaccines are given to treat genital herpes signs and symptoms, while prophylactic vaccines are given to prevent infection.</p> Signup and view all the answers