Understanding Hormone Therapy

• It is important to understand women's hormones
• Menopause can be the best time in a woman's life if her hormones are balanced

Defining Objectives of Hormone Therapy

• The activity of hormone therapy aims to educate on hormones from the steroidogenic pathway, sex hormones, replacing hormones, melatonin functions, insulin, adrenal hormones, estrogen, progesterone, and testosterone

Individual Hormone Response

• Each unique hormone responds and is unique to the individual, like fingerprints
• Thorough understanding is required between all hormones in the body, especially when replacing hormones

Synthetic HRT Issues

• Half of women commonly quit synthetic hormone replacement within the first year due to being unable to tolerate side effects
• Synthetic hormones can waste energy by providing incomplete signals to cells which fail to output a balanced response

Benefits of HRT

• HRT can be considered for relief from symptoms, the prevention of memory loss, and to support heart health, bone production, growth and repair

Hormones for Growth and Repair

• Important hormones for growth and repair are Insulin, growth hormone, testosterone, estrogens, and DHEA

Symptoms of Menopause

• Common symptoms of menopause are hot flashes, night sweats, vaginal dryness, anxiety, mood swings, irritability, insomnia, and depression
• Additional symptoms can include low sexual interest, hair growth on the face, painful intercourse, panic attacks, weird dreams, UTIs, and vaginal itching, lower back pain, and bloating
• Additional symptoms can include flatulence, indigestion, osteoporosis, aching joints, hair loss, frequent urination, snoring, and sore breasts
• Palpitations, varicose veins, urinary leakage, dizzy spells, anxiety, skin feeling crawly, migraine headaches, memory lapses, and weight gain are additional symptoms

Estrogen

• Estrogen is responsible for approximately 400 duties in the body, including the production of choline acetyltransferase, which has been shown to prevent Alzheimer's disease and increase metabolic rate
• Estrogen improves insulin sensitivity, regulates body temperature, prevents muscle damage, maintains muscle mass, and improves sleep
• It may also reduce the risk of cataracts, maintain artery elasticity, dilate small arteries, and increase blood flow with platelet stickiness
• Estrogen can enhance magnesium uptake, maintain skin collagen, decrease blood pressure, and prevent LDL oxidation
• Memory, reasoning, fine motor skills are improved as well skin thickness and softness, nerve-growth factor production and a positive effect on emotions
• It increases HDL by 10-15% and reduces heart disease risk by 40-50%
• By acting as the body's natural calcium channel blocker, arteries stay open and energy concentration improves; mood is also improved
• Maintains bone density and is shown to help prevent glaucoma
• Enhances sexual interest, reduces homocysteine, and decreases wrinkles
• Aids in the formation of neurotransmitters like serotonin to decrease depression, irritability, anxiety, and pain sensitivity

Estrogen Excess

• Cervical dysplasia, depression with anxiety or agitation are all symptoms of high estrogen, including a high risk of uterine cancer
• Weight gain and water retention are common
• Symptoms of heavy periods, increased rates of breast cancer and autoimmune diseases, and hypothyroidism
• Irritability, mood swings, fatigue, uterine fibroids, or bloating

Causes of Increased Estrogen

• Increased elimination and low exercise intake
• Low intake of grains and fiber with presence of environmental estrogens

Synthetic Estrogen

• It is not the same chemical structure as naturally produced estrogen
• the most commonly available are estrone and sodium equilin sulfate

Alpha-Dihydroequilin, Alpha-Estradiol, Beta-Dihydroequilin

• These are common components of synthetic estrogen

Natural Estrogen

• Has the same chemical make-up as that is naturally produced
• Natural estrogen may not originate from plants
• Aids in protection against endothelial dysfunction by increasing endothelial nitric oxide

Endothelial Nitric and Equine Estrogens

• Endothelial nitric oxide synthase is crucial in the production of nitric oxide synthase in cells
• Compared, gene transcription of endothelial nitric oxide synthase was 30-50% lower in reaction to equine hormones

Estrogen Types

• E1 (Estrone)
  • The prominent estrogen that the body produces after menopause
  • Several researchers suggest that its high levels may contribute to a higher risk of breast cancer for women
• E2 (Estradiol)
  • HDL is increased and LDL is decreased when total cholesterol is made, as well as Decreased triglycerides
  • Helps maintain bone structure and boost serotonin, also helping minimize fatigue and is an antioxidant
  • Supports memory and absorption of calcium, magnesium, and zinc
    • A recent trial reveals it has a direct effect in reducing atherosclerosis by reducing cholesterol accumulation in the arterial wall
• E3 (Estriol)
  • Due to its 80x weaker level than E2, it has a lesser stimulatory effect
  • Ample evidence to defends against cancer
  • Being used on breast cancer patients experimentally
  • Does not have the bone defenses of estradiol
• E3's function within the body:
  • Used to support pregnancy and benefits the vaginal lining
  • Blocks E1 by filling the estrogen receptor locations
  • Used to govern menopausal symptoms
  • Decreasing LDL while increasing HDL
  • Can help eliminate pathogenic bacterias, restore the body's pH balance, & protect against UTIs
  • Can help ensure the GI tract is in the right condition

Importance of Estriol

• Estriol, discusses emerging roles for estriol in the treatment of menopausal symptoms, osteoporosis, cancer, hyperlipidemia, vascular disease, and multiple sclerosis

Types of Estrogen Receptor Alpha and Beta

• Estrogen comes with two main receptors
  • Alpha estrogen receptors can cause increased growth in reproductive tissues
  • Beta estrogen receptor works to limit cells in growth, can hinder cancer progression and gives advantages to the dermis, bones, encephalon and other fiber

Estrogen and HRT

• E2 equally activates the alpha and beta estrogen-receptors
• Cell proliferation is increased because E1 estrogen receptor stimulates the alpha selectivity at a 5:1 ratio
• The estrogen-receptor beta is bonded in preferential to E3 at a 3:1 ratio, which has been shown to prevent breast cancer
• Siberian rhubarb is shown to stimulate receptor ER beta at an advanced range when compared to ER-alpha receptors

Estrogen Metabolism

• The rate of metabolism can change after menopause, indicating a women may react different in estrogen replacment

Estrogen Metabolism Pathways

• 2OH estrone
  • Does not trigger cell growth
  • Blocks the process of stronger estrogen fibers
  • Serves as protection against dangerous elements when methylated by COMT methyltransferase by the 2 methoxyestrone
  • The amount methoxyestrone / hydroxyestrone can be assessed in urine and used as an indicator of methylation function
• The body is able to evaluate when homocysteine has increased
• Low ratios of 2/16 hydroxy estrogen are also associated with an increased rate of developing lupus

Methylation Factors

• SAMe, Methionine, B2, B6, B12 and TMG
• Supplementing Folic, Folinic, and 5-methyltetrahydrofolate Acids are ways to factor Methylation, also decreasing stress and catecholamine production assists in balancing Estrone/Methylation

Estrone

• Displays impressive strong hormone properties and experiments show its likely to to be related with higher risk of breast cell damages
• Elevated density can give rise to:
  • Obesity
  • Hypothyroidism
  • Poisoning from insecticides
  • Raised amounts of lipids
  • Inflammatory Cytokines

Estrone studies show

• Harm DNA
• Equine like Premarin, trigger metabolism to 4OH estrones, an accumulation caused from deficits from methionine and folate, individuals affected from fiber tumors may output advanced proportions of 4OH Estrone

Assistance to Estrone

• Exercise
  • Greens like broccoli
  • Kudzu
  • Flax
  • Supplements with doses of 200/300 every day to help with I3C amounts
    • Omega 3 fatty acids, b6,b13 and folate is very effective

Factors Causing Impact

• Gaining weight can make lower 2OH amounts and high 16OH amounts because of low glucose

Xenoestrogens

• 50 Toxic compounds that can lead to hazardous results in the body
  • Pesticides, Hormones and Cosmetics and Plastics also factor
• It can create issues when extracting the right compounds because certain medications increase estrogen's capacity

Alcohol and Estrogen

• Interfere through disrupting the Liver's proficiency to detox and increases levels of estrone that contribute to harmful results like breast ailments

Estrogen and the Brain

• Most individuals have similar reactions of:
  • Lack of thought
  • The body functions different
  • Losing a certain skill with spells
  • Misplacing things
• Low volume increase in blood flow, glucose, defense of neurotransmitters and sustains the barrier for an effective stream

Estrogen and the Heart

• With benefits from treatment and results from Cardiovascular function and WHI/ELITE trials shows that menopausal hormone care to protect the heart of ladies without harm between 6/10 years

Progesterone Information

• This steroid is one of the main sex drivers to protect the system during pregnancy and protect women's bodies, especially after menopause
  • There are issues, and there are also artificial compounds used, natural ways are more beneficial

Progesterone Functionality

• Works as agent to fight inflammations
• Support estrogen count and hormone responses
  • A major factor to preserve hydration, oxygen and functions
  • Increase scalp hair and make the body more functional and adaptive
• Elevating amounts lowers cholesterol/blood values

Common Symptoms of Declining Levels

• Triggered actions around feelings like nervousness that can cause headaches
• Actions are weight increase, reduced excitement and reduced HDL functions

Factors Leading to Reduced Capacity

• Stress is an issue and can increase or impact with
  • Low intake of amino acids that influence function, hormones needed, or fiber and vitamin imbalances

Risks of Using Other Types for Care

• Does not display similar functions like the other type of protection
  • Actions have been related too, more appetite, mass gain a headache to protect the system instead

Progesterone

• A common process has replication to increase, leading to higher risk and can impact in the long run

Treatment to improve

• Supplementation/Creams and P.O. types that assist receptors from experts that will allow greater aid versus applied types

Testosterone facts

• Will add stimulation/interest towards actions plus give better sensation and well feeling
• Also help to be more acute or present while defending the bone with elevation to mood by controlling the effect Low testosterone has common factors
• Actions like fatigue, low actions with self esteem will become present or have thinning skin will trigger reactions
• Hair or even bad memories start to fail by those results
• Conditions triggered are high hormone production and disorders