Hormone Replacement Therapy and Breast Cancer Risk Quiz
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Questions and Answers

What is the structural analogue of spironolactone?

  • Levonorgestrel
  • Desogestrel
  • Drospirenone (correct)
  • Norethindrone
  • Which of the following is a C-19 progestin with anti-androgenic activity?

  • Drospirenone (correct)
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • What is the main mechanism of action of Clomiphene citrate?

  • Estrogen receptor antagonist
  • GnRH agonist
  • LH agonist
  • FSH inhibitor (correct)
  • Which C-19 progestin has minimal or no overall androgenic side effects?

    <p>Drospirenone</p> Signup and view all the answers

    How do hormonal contraceptives like birth control pills affect FSH and LH release from the pituitary?

    <p>Decrease FSH and LH release</p> Signup and view all the answers

    What is the main reason why estrogen is used alone should be given in a cyclic administration?

    <p>To mimic natural hormone fluctuations</p> Signup and view all the answers

    In what condition should estrogen therapy be used in combination with progesterone?

    <p>Primary hypogonadism</p> Signup and view all the answers

    Which hormone replacement therapy is increasingly discouraged in postmenopausal women due to increased risks of breast cancer and cardiovascular events?

    <p>Combination of estrogen and progesterone</p> Signup and view all the answers

    What is the primary function of continual administration of combination estrogen/progestin oral contraceptives for acne?

    <p>Decreases ovarian androgen synthesis</p> Signup and view all the answers

    Which condition does estrogen primarily target by inhibiting bone resorption but not stimulating new bone synthesis?

    <p>Post-menopausal osteoporosis</p> Signup and view all the answers

    What is the mechanism of action of drugs that block the production of ovarian-stimulating hormones?

    <p>Lower estrogen levels</p> Signup and view all the answers

    Which drug can relieve endometriosis signs and symptoms by halting menstrual periods and the growth of endometrial implants?

    <p>Depo-Provera</p> Signup and view all the answers

    Which type of C-19 progestins has anti-androgenic activity?

    <p>Drospirenone</p> Signup and view all the answers

    What is the concern related to the duration of therapy limitation for GnRH agonists in treating pelvic pain caused by endometriosis?

    <p>Significant bone loss</p> Signup and view all the answers

    Which contraceptive method can help inhibit endometrial tissue growth by causing initial decidualization and then atrophy?

    <p>Intrauterine device with levonorgestrel (Mirena)</p> Signup and view all the answers

    How do combination oral contraceptives help reduce dermatological manifestations in women with PCOS?

    <p>By inhibiting gonadotropin secretion and ovarian androgen secretion</p> Signup and view all the answers

    Which enzyme is more commonly known as 'Aromatase'?

    <p>CYP19</p> Signup and view all the answers

    What is one of the overall goals of therapy for women with PCOS?

    <p>To prevent endometrial hyperplasia and carcinoma</p> Signup and view all the answers

    How do high and low GnRH pulse frequencies affect LH and FSH release, respectively?

    <p>Low GnRH pulse frequencies favor LH release</p> Signup and view all the answers

    Which medication is commonly used for ovulation induction in women pursuing pregnancy?

    <p>Clomiphene citrate</p> Signup and view all the answers

    Which class of enzymes is important in the growth and implantation of ectopic endometrium?

    <p>Matrix metalloproteinases</p> Signup and view all the answers

    Which medication acts as an antagonist at estrogen receptors in the breast but a partial agonist at estrogen receptors in the endometrium and bone?

    <p>Tamoxifen</p> Signup and view all the answers

    Which drug is primarily used for the treatment of breast cancers that are estrogen receptor-positive?

    <p>Toremifene</p> Signup and view all the answers

    Which medication is a structural analogue of spironolactone?

    <p>Drospirenone</p> Signup and view all the answers

    Which type of progestins have minimal or no overall androgenic side effects?

    <p>C-19 Progestins with anti-androgenic activity</p> Signup and view all the answers

    Which contraceptive method involves inserting a T-shaped piece of plastic that releases the progestin levonorgestrel?

    <p>IUD</p> Signup and view all the answers

    Which contraceptive method contains ethinyl estradiol and norelgestromin in a patch form?

    <p>Patch</p> Signup and view all the answers

    Which contraceptive method involves capsules of etonorgestrel placed under the skin for slow release up to 3 years?

    <p>Subdermal implant</p> Signup and view all the answers

    Which contraceptive method is reusable for one year and consists of segesterone and ethinyl estradiol?

    <p>Annovera®</p> Signup and view all the answers

    Which contraceptive method is administered as an injection every 3 months and contains medroxyprogesterone acetate?

    <p>Depo-Provera®</p> Signup and view all the answers

    Which medication is commonly used in women for the treatment of endometriosis, uterine fibroids, POCS, and hirsutism?

    <p>Goserelin</p> Signup and view all the answers

    What are the side effects commonly experienced by women using medications like leuprolide, goserelin, and nafarelin?

    <p>Hot flashes/sweats and depression</p> Signup and view all the answers

    Which medication is contraindicated in pregnancy and breastfeeding?

    <p>Goserelin</p> Signup and view all the answers

    What is the main use of GnRH antagonists like Cetrorelix and Ganirelix?

    <p>Assisted reproduction to suppress FSH/LH release</p> Signup and view all the answers

    What is the purpose of using GnRH antagonists in fertility treatment?

    <p>Prevent LH surge to avoid premature ovulation</p> Signup and view all the answers

    Which medication is approved for the treatment of advanced prostate cancer?

    <p>Degarelix</p> Signup and view all the answers

    What is the primary side effect associated with GnRH antagonists when used in fertility treatments?

    <p>Abdominal pain</p> Signup and view all the answers

    What is the main reason GnRH antagonists are used in vitro fertilization?

    <p>To prevent LH surge for laproscopic harvest of ova</p> Signup and view all the answers

    What is the common side effect associated with Drospirenone use in women?

    <p>Headache and nausea</p> Signup and view all the answers

    Which medication suppresses endogenous FSH/LH release to give exogenous FSH followed by midcycle LH for fertilization?

    <p>Bromocriptine mesylate</p> Signup and view all the answers

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