Understanding Gene Therapy Quiz
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Understanding Gene Therapy Quiz

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@ExaltingVictory

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Questions and Answers

What is the main goal of gene therapy?

  • To isolate and insert genes into somatic cells
  • To treat loss-of-function genetic disorders by delivering correcting therapeutic DNA sequences into the nucleus of a cell (correct)
  • To amplify diseased cells
  • To introduce therapeutic genes into germ-cells or specific type of embryonal cells

    • What is the division of gene therapy that aims for the introduction of therapeutic genes into germ-cells or specific type of embryonal cells?

  • Hereditary gene therapy
  • Somatic gene therapy
  • Embryonic gene therapy
  • Germ-line gene therapy (correct)

    • Which type of gene therapy allows genetic manipulation of a patient’s somatic cells for the purpose of correcting severe disorders?

  • Somatic gene therapy (correct)
  • Germ-line gene therapy
  • Embryonic gene therapy
  • Hereditary gene therapy

    • What are the principles of gene therapy?

    <p>All of the above</p> Signup and view all the answers

    What is a major limitation of gene therapy, related to the nature of cells?

    <p>Difficulty in rapidly integrating therapeutic DNA into the genome due to rapidly dividing cells</p> Signup and view all the answers

    What was the first disease target for gene therapy?

    <p>SCID (Severe Combined Immunodeficiency)</p> Signup and view all the answers

    What is the first gene therapy product known as Gendicine designed to treat?

    <p>Tumors with mutated p53 genes</p> Signup and view all the answers

    What is the gene therapy approach for treating Cystic Fibrosis?

    <p>Uses viruses (adenoassociated viral vector) and liposomes sprayed into nose &amp; mouth</p> Signup and view all the answers

    What is a characteristic of suicide gene therapy for cancer?

    <p>Uses Herpes simplex virus Thymidine kinase (HSV-tk) gene coupled with Ganciclovir (GCV)</p> Signup and view all the answers

    What is the major concern about using viral vectors in gene therapy?

    <p>Potential toxic, immune, and inflammatory response in patients</p> Signup and view all the answers

    "Hard to rapidly integrate therapeutic DNA into genome" is a limitation of gene therapy due to:

    <p>Rapidly dividing nature of cells</p> Signup and view all the answers

    What is the main challenge in treating multigene disorders with gene therapy?

    <p>&quot;Limitation with multigene disorders&quot;</p> Signup and view all the answers

    "New things introduced into the body leads to immune response" is a limitation related to:

    <p>&quot;Viral Vectors&quot; used in gene therapy</p> Signup and view all the answers

    "The first gene therapy was performed on September 14th, 1990" was targeted at treating which condition?

    <p>&quot;SCID (Severe Combined Immunodeficiency)&quot;</p> Signup and view all the answers

    "Gendicine is a recombinant adenovirus engineered to express wildtype-p53" is designed for treating:

    <p>&quot;Tumors with mutated p53 genes&quot;</p> Signup and view all the answers

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