Podcast
Questions and Answers
What is the initial event in the process of carcinogenesis?
What is the initial event in the process of carcinogenesis?
- Genetic damage (correct)
- Neoplastic proliferation
- Inherited carcinogenesis
- Environmental factors
Which type of genes are the main targets of genetic damage in carcinogenesis?
Which type of genes are the main targets of genetic damage in carcinogenesis?
- Apoptosis inhibiting genes
- Metastatic genes
- DNA repair genes
- Growth promoting protooncogenes (correct)
What are the main changes in cell physiology that lead to the formation of the malignant phenotype?
What are the main changes in cell physiology that lead to the formation of the malignant phenotype?
- Insensitivity to growth-inhibitory signals
- Limitless replicative potential
- Sustained angiogenesis
- All of the above (correct)
What do oncogenes promote in cancer cells?
What do oncogenes promote in cancer cells?
Which of the following is characterized by the ability to promote cell growth in the absence of normal growth-promoting signals?
Which of the following is characterized by the ability to promote cell growth in the absence of normal growth-promoting signals?
What is the main function of oncoproteins?
What is the main function of oncoproteins?
What is the effect of mutations in protooncogenes?
What is the effect of mutations in protooncogenes?
What is the role of growth-inhibiting (suppressor) genes in carcinogenesis?
What is the role of growth-inhibiting (suppressor) genes in carcinogenesis?
What is the consequence of sustained angiogenesis in carcinogenesis?
What is the consequence of sustained angiogenesis in carcinogenesis?
Which gene type plays a role in regulating apoptosis in carcinogenesis?
Which gene type plays a role in regulating apoptosis in carcinogenesis?
What is the primary function of DNA repair genes in carcinogenesis?
What is the primary function of DNA repair genes in carcinogenesis?
What is meant by clonal expansion in the context of neoplastic proliferation?
What is meant by clonal expansion in the context of neoplastic proliferation?
What is a common characteristic of cancer cells related to growth factors?
What is a common characteristic of cancer cells related to growth factors?
How can mutation in receptors contribute to cancer cell growth?
How can mutation in receptors contribute to cancer cell growth?
What role do signal-transducing proteins play in cancer cell development?
What role do signal-transducing proteins play in cancer cell development?
Which gene, when disrupted by mutation, can cause insensitivity to growth inhibition in cancer cells?
Which gene, when disrupted by mutation, can cause insensitivity to growth inhibition in cancer cells?
What is the main function of the TP53 gene?
What is the main function of the TP53 gene?
What is the consequence of losing TP53 function in cancer cells?
What is the consequence of losing TP53 function in cancer cells?
What is one of the main effects of sustained angiogenesis in cancer cells?
What is one of the main effects of sustained angiogenesis in cancer cells?
What role does neovascularization play in cancer metastasis?
What role does neovascularization play in cancer metastasis?
What are the two phases involved in the ability of cancer cells to invade and metastasize?
What are the two phases involved in the ability of cancer cells to invade and metastasize?
What are the main changes in cell physiology that lead to formation of the malignant phenotype?
What are the main changes in cell physiology that lead to formation of the malignant phenotype?
What is telomerase's role in tumor cells?
What is telomerase's role in tumor cells?
