Understanding Autoimmune Diseases
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Questions and Answers

What happens in an autoimmune disease?

  • The immune system attacks foreign invaders only
  • The immune system recognizes self and non-self-antigens clearly
  • The immune system targets the body's own tissues (correct)
  • The immune system protects the body from pathogens effectively

How do genetic variations in MHC genes contribute to autoimmune diseases?

  • They prevent tissue inflammation
  • They increase susceptibility to autoimmune diseases (correct)
  • They stimulate anti-inflammatory responses
  • They enhance regulatory T cell function

What role do environmental factors play in triggering autoimmune responses?

  • They prevent the activation of DCs
  • They reduce inflammation in affected tissues
  • They have no impact on autoimmune diseases
  • They can cause tissue inflammation leading to autoimmune responses (correct)

In autoimmune diseases, what can dysfunction in regulatory T cells lead to?

<p>Imbalance between pro-inflammatory and anti-inflammatory responses (C)</p> Signup and view all the answers

What happens when the immune system fails to distinguish between foreign invaders and the body's own cells?

<p>Tissue inflammation, damage, and organ dysfunction occur (C)</p> Signup and view all the answers

What initiates the activation of self-reactive T lymphocytes in autoimmune diseases?

<p>Tissue inflammation due to environmental factors (A)</p> Signup and view all the answers

______ is a condition in which the body's immune system mistakenly attacks its own tissues

<p>Autoimmune disease</p> Signup and view all the answers

The immune system identifies and targets foreign substances such as bacteria, viruses, and other pathogens to protect the body from ______

<p>foreign invaders</p> Signup and view all the answers

Dysfunction in the regulatory mechanisms of the immune system, including impaired function of regulatory T cells, can lead to an imbalance between pro-inflammatory and anti-inflammatory responses, contributing to the development of ______ diseases

<p>autoimmune</p> Signup and view all the answers

Certain genetic variations in the major histocompatibility complex (MHC) genes can increase susceptibility to autoimmune diseases by influencing how the immune system recognises self and ______

<p>non-self-antigens</p> Signup and view all the answers

Environmental factors such as viral infections can trigger autoimmune responses by causing tissue ______

<p>inflammation</p> Signup and view all the answers

In autoimmune diseases, the immune system fails to distinguish between foreign invaders and the body’s own cells, leading to ______, tissue damage, and dysfunction of affected organs or systems

<p>inflammation</p> Signup and view all the answers

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