Understanding Airway Resistance

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Questions and Answers

Which of the following is the correct equation to determine airway resistance (AWR)?

  • AWR = Air flow / Cross sectional area
  • AWR = Driving pressure / Cross sectional area
  • AWR = (Driving pressure / Air flow) x Cross sectional area
  • AWR = Driving pressure / Air flow (correct)

In healthy individuals, where is the major site of resistance to flow of air?

  • Smaller airways
  • Larger airways (correct)
  • All airways have equal resistance
  • Mid-size airways

In most common disease states, where is the major site of resistance to flow of air?

  • Larger airways
  • All airways have equal resistance
  • Mid-size airways
  • Smaller airways (correct)

What are some factors that can cause a reduction in the luminal size of the smaller airways?

<p>All of the above (D)</p> Signup and view all the answers

What is airway resistance (AWR)?

<p>The force to reduce the air flow (in opposite air flow direction) during respiration (B)</p> Signup and view all the answers

Which factor indicates high airway resistance?

<p>Slow air flow and high driving pressure (D)</p> Signup and view all the answers

What causes airway resistance?

<p>The friction between the walls of the airway and the airflow (C)</p> Signup and view all the answers

In which generation of the bronchi have the greatest airway resistance?

<p>Generation 3 (C)</p> Signup and view all the answers

What factors can affect airway diameter?

<p>All of the above (D)</p> Signup and view all the answers

What is the mechanism of mechanical tethering in relation to airway diameter?

<p>It stretches and distends the airways during lung inflation (D)</p> Signup and view all the answers

What can cause the narrowing of the airway lumen during massive mucus secretion?

<p>Inflammation (C)</p> Signup and view all the answers

Which factor helps keep the alveoli open?

<p>Alveolar Interdependence (D)</p> Signup and view all the answers

What is a characteristic of asthma in terms of airway inflammation?

<p>Chronic inflammation (D)</p> Signup and view all the answers

Which condition is associated with higher airway resistance (AWR)?

<p>Chronic bronchitis/COPD (D)</p> Signup and view all the answers

Which neurotransmitter is responsible for parasympathetic stimulation in the autonomic nervous system?

<p>Acetylcholine (C)</p> Signup and view all the answers

Which neurotransmitter is responsible for sympathetic stimulation in the autonomic nervous system?

<p>Noradrenaline (D)</p> Signup and view all the answers

Which type of mediator is responsible for non-adrenergic non-cholinergic (NANC) stimulation in the autonomic nervous system?

<p>Vasoactive intestinal peptide (D)</p> Signup and view all the answers

Which type of drug can reduce airway resistance by blocking parasympathetic stimulation?

<p>Anticholinergic (B)</p> Signup and view all the answers

Which receptors are abundantly expressed on human airway smooth muscle and their stimulation causes bronchodilation?

<p>β-adrenergic receptors (D)</p> Signup and view all the answers

Which part of the airways has high density parasympathetic innervation?

<p>Bronchial smooth muscle (C)</p> Signup and view all the answers

What is the effect of sympathetic stimulation on airway smooth muscle?

<p>bronchodilation and less secretion (D)</p> Signup and view all the answers

What is the effect of parasympathetic stimulation on airway smooth muscle?

<p>Bronchoconstriction and secretion (A)</p> Signup and view all the answers

Which receptor is responsible for the contraction of airway smooth muscle when acetylcholine binds to it?

<p>M3 muscarinic receptor (D)</p> Signup and view all the answers

Which receptor limits further acetylcholine release in the parasympathetic nervous system?

<p>M2 muscarinic receptor (C)</p> Signup and view all the answers

What is the cause of histamine release in the airways?

<p>All of the above (D)</p> Signup and view all the answers

Which neurotransmitter is responsible for parasympathetic stimulation in the autonomic nervous system?

<p>Acetylcholine (A)</p> Signup and view all the answers

Which reflex mechanism is triggered by parasympathetic stimulation and helps cough out irritant particles?

<p>Increased mucus production (A)</p> Signup and view all the answers

Which molecule is responsible for increasing smooth muscle contraction, vascular permeability, and mucus secretion?

<p>Histamine (D)</p> Signup and view all the answers

Which type of stimulation is important for the cough reflex?

<p>Parasympathetic stimulation (B)</p> Signup and view all the answers

What happens to bronchospasm and reflex mechanisms in asthma?

<p>They are exaggerated (C)</p> Signup and view all the answers

What is the role of increased mucus production in the airways during parasympathetic stimulation?

<p>It helps to cough out particles (A)</p> Signup and view all the answers

Which receptors are targeted by β2-adrenergic agonists to induce bronchodilation?

<p>Beta-adrenergic receptors (C)</p> Signup and view all the answers

Which type of stimulation is responsible for the release of histamine from mast cells in the airways?

<p>Parasympathetic stimulation (B)</p> Signup and view all the answers

Which class of drugs acts on muscarinic receptors in the parasympathetic stimulation to counteract bronchoconstriction?

<p>M3 muscarinic antagonists (C)</p> Signup and view all the answers

Which type of stimulation leads to bronchodilation and less secretion in the airways?

<p>Sympathetic stimulation (A)</p> Signup and view all the answers

What is the role of NANC (non-adrenergic non-cholinergic) neurotransmitters in the autonomic nervous system?

<p>They are part of the parasympathetic nervous system (B)</p> Signup and view all the answers

Which of the following is NOT an example of a β2-adrenoceptor agonist used for bronchodilation?

<p>Atropine (C)</p> Signup and view all the answers

What is the effect of β2-adrenoceptor agonists on mediator release from mast cells?

<p>Inhibition of mediator release (B)</p> Signup and view all the answers

Which type of pharmacological intervention acts on muscarinic receptors to block the effects of parasympathetic stimulation?

<p>M3 muscarinic antagonists (C)</p> Signup and view all the answers

Which type of receptor is targeted by anti-histamines in the context of parasympathetic stimulation?

<p>H1 receptor (D)</p> Signup and view all the answers

Select the correct statement on airway resistance:

<p>Increased muscle tone of respiratory tract results in higher airway resistance (D)</p> Signup and view all the answers

Select the correct statement on autonomic nervous system of respiratory system:

<p>There is no sympathetic innervation on the smooth muscle of respiratory tract (B)</p> Signup and view all the answers

Select the best statement on parasympathetic nervous system on respiratory system.

<p>The mast cells release the histamine and cause bronchoconstriction when one is inhaling the cold air or contacted with air-borne allergens (C)</p> Signup and view all the answers

Select the correct statement on sympathetic nervous system on respiratory system.

<p>Stimulation of sympathetic nervous system increases the cAMP level in respiratory tract smooth muscle (D)</p> Signup and view all the answers

Select the correct statement on drug in reducing the airway resistance.

<p>Parasympathetic antagonist like atropine is helpful in inhibiting the bronchial muscle tone and secretion (A)</p> Signup and view all the answers

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