Typical Antipsychotics: Classification and Characteristics

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What is the main characteristic of first-generation antipsychotics in terms of their binding affinity?

They bind with high affinity to dopamine D1 receptors

They bind with high potency to dopamine D2 receptors

They bind with low potency to dopamine D2 receptors (correct)

They bind with moderate potency to serotonin receptors

Which of the following antipsychotics is most likely to be associated with extrapyramidal symptoms (EPS)?

Chlorpromazine

Risperidone

Clozapine

Haloperidol (correct)

What is the main difference between first-generation and second-generation antipsychotics in terms of their side effect profiles?

Second-generation antipsychotics have a higher risk of extrapyramidal symptoms

First-generation antipsychotics have a higher risk of metabolic adverse effects

Second-generation antipsychotics have a lower risk of extrapyramidal symptoms (correct)

First-generation antipsychotics have a lower risk of metabolic adverse effects

Which of the following antipsychotic drugs is an inverse agonist of 5-HT2A and antagonist of 5-HT2C?

Pimavanserin (B) Signup and view all the answers

Which of the following receptors is blocked by Clozapine to a lesser extent?

D2 receptor (A) Signup and view all the answers

What is the primary mechanism of antipsychotic action of most antipsychotic drugs?

Blockade of dopamine and/or serotonin receptors (D) Signup and view all the answers

What is the mechanism of action of most second-generation antipsychotics?

Blockade of dopamine D2 receptors and serotonin 5-HT2 receptors (D) Signup and view all the answers

Which of the following symptoms is not improved by typical antipsychotics?

Cognitive impairment (C) Signup and view all the answers

Which of the following antipsychotic drugs is not used as an antiemetic?

Aripiprazole (B) Signup and view all the answers

Which of the following is a characteristic of third-generation antipsychotics?

They are partial agonists at D2 and 5-HT1A receptors (D) Signup and view all the answers

What is the effect of antipsychotic drugs on prolactin release?

Increase prolactin release (B) Signup and view all the answers

What is the mechanism of orthostatic hypotension caused by antipsychotic drugs?

Alpha receptor blockade (D) Signup and view all the answers

What is the primary indication of Pimozide?

Treatment of Tourette's disorder (B) Signup and view all the answers

What is the primary mechanism of action of antipsychotics in relation to the brain?

They have a large volume of distribution and bind well to plasma proteins (D) Signup and view all the answers

What is the primary treatment for tardive dyskinesia?

Vesicular monoamine transporter inhibitors such as valbenazine and deutetrabenazine (D) Signup and view all the answers

What is the primary risk associated with the use of antipsychotics in elderly patients with dementia?

Increased risk of mortality (D) Signup and view all the answers

What is the primary difference between low-potency and high-potency antipsychotics?

Low-potency antipsychotics are highly sedative whereas high-potency drugs cause less sedation (B) Signup and view all the answers

What is the primary mechanism of action of valbenazine and deutetrabenazine in treating tardive dyskinesia?

They are vesicular monoamine transporter inhibitors (D) Signup and view all the answers

What is the primary effect of the anticholinergic properties of Olanzapine?

Causing dryness of mouth and constipation (D) Signup and view all the answers

What is the characteristic of Resiperidone in comparison to Clozapine?

It is a more potent D2 blocker and causes more extrapyramidal symptoms (D) Signup and view all the answers

What is the effect of antipsychotic drugs on motor coordination?

They cause minimal motor incoordination (B) Signup and view all the answers

What is the time frame for the therapeutic effects of antipsychotic drugs to occur?

Within days to weeks (C) Signup and view all the answers

What is the mechanism of action of Olanzapine in reducing spontaneous physical movement?

By reducing corticostriatal pathway activity (B) Signup and view all the answers

What is a characteristic of high potency drugs compared to low potency drugs?

They have lower anticholinergic and autonomic side effects (B) Signup and view all the answers

Which of the following antipsychotic drugs has the strongest anticholinergic activity?

Chloropromazine, thioridazine, and clozapine (D) Signup and view all the answers

What is a characteristic of pimozide?

It selectively blocks D2 receptors without affecting α and muscarinic receptors (D) Signup and view all the answers

What is the most common adverse effect of clozapine?

Sedation (B) Signup and view all the answers

Which of the following antipsychotic drugs is available in an injectable form?

Fluphenazine and haloperidol (C) Signup and view all the answers

What is a characteristic of haloperidol?

It is a highly potent typical antipsychotic drug with a low incidence of extrapyramidal symptoms (B) Signup and view all the answers