Typical Antipsychotics: Classification and Characteristics
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Questions and Answers

What is the main characteristic of first-generation antipsychotics in terms of their binding affinity?

  • They bind with high affinity to dopamine D1 receptors
  • They bind with high potency to dopamine D2 receptors
  • They bind with low potency to dopamine D2 receptors (correct)
  • They bind with moderate potency to serotonin receptors

Which of the following antipsychotics is most likely to be associated with extrapyramidal symptoms (EPS)?

  • Chlorpromazine
  • Risperidone
  • Clozapine
  • Haloperidol (correct)

What is the main difference between first-generation and second-generation antipsychotics in terms of their side effect profiles?

  • Second-generation antipsychotics have a higher risk of extrapyramidal symptoms
  • First-generation antipsychotics have a higher risk of metabolic adverse effects
  • Second-generation antipsychotics have a lower risk of extrapyramidal symptoms (correct)
  • First-generation antipsychotics have a lower risk of metabolic adverse effects

Which of the following antipsychotic drugs is an inverse agonist of 5-HT2A and antagonist of 5-HT2C?

<p>Pimavanserin (B)</p> Signup and view all the answers

Which of the following receptors is blocked by Clozapine to a lesser extent?

<p>D2 receptor (A)</p> Signup and view all the answers

What is the primary mechanism of antipsychotic action of most antipsychotic drugs?

<p>Blockade of dopamine and/or serotonin receptors (D)</p> Signup and view all the answers

What is the mechanism of action of most second-generation antipsychotics?

<p>Blockade of dopamine D2 receptors and serotonin 5-HT2 receptors (D)</p> Signup and view all the answers

Which of the following symptoms is not improved by typical antipsychotics?

<p>Cognitive impairment (C)</p> Signup and view all the answers

Which of the following antipsychotic drugs is not used as an antiemetic?

<p>Aripiprazole (B)</p> Signup and view all the answers

Which of the following is a characteristic of third-generation antipsychotics?

<p>They are partial agonists at D2 and 5-HT1A receptors (D)</p> Signup and view all the answers

What is the effect of antipsychotic drugs on prolactin release?

<p>Increase prolactin release (B)</p> Signup and view all the answers

What is the mechanism of orthostatic hypotension caused by antipsychotic drugs?

<p>Alpha receptor blockade (D)</p> Signup and view all the answers

What is the primary indication of Pimozide?

<p>Treatment of Tourette's disorder (B)</p> Signup and view all the answers

What is the primary mechanism of action of antipsychotics in relation to the brain?

<p>They have a large volume of distribution and bind well to plasma proteins (D)</p> Signup and view all the answers

What is the primary treatment for tardive dyskinesia?

<p>Vesicular monoamine transporter inhibitors such as valbenazine and deutetrabenazine (D)</p> Signup and view all the answers

What is the primary risk associated with the use of antipsychotics in elderly patients with dementia?

<p>Increased risk of mortality (D)</p> Signup and view all the answers

What is the primary difference between low-potency and high-potency antipsychotics?

<p>Low-potency antipsychotics are highly sedative whereas high-potency drugs cause less sedation (B)</p> Signup and view all the answers

What is the primary mechanism of action of valbenazine and deutetrabenazine in treating tardive dyskinesia?

<p>They are vesicular monoamine transporter inhibitors (D)</p> Signup and view all the answers

What is the primary effect of the anticholinergic properties of Olanzapine?

<p>Causing dryness of mouth and constipation (D)</p> Signup and view all the answers

What is the characteristic of Resiperidone in comparison to Clozapine?

<p>It is a more potent D2 blocker and causes more extrapyramidal symptoms (D)</p> Signup and view all the answers

What is the effect of antipsychotic drugs on motor coordination?

<p>They cause minimal motor incoordination (B)</p> Signup and view all the answers

What is the time frame for the therapeutic effects of antipsychotic drugs to occur?

<p>Within days to weeks (C)</p> Signup and view all the answers

What is the mechanism of action of Olanzapine in reducing spontaneous physical movement?

<p>By reducing corticostriatal pathway activity (B)</p> Signup and view all the answers

What is a characteristic of high potency drugs compared to low potency drugs?

<p>They have lower anticholinergic and autonomic side effects (B)</p> Signup and view all the answers

Which of the following antipsychotic drugs has the strongest anticholinergic activity?

<p>Chloropromazine, thioridazine, and clozapine (D)</p> Signup and view all the answers

What is a characteristic of pimozide?

<p>It selectively blocks D2 receptors without affecting α and muscarinic receptors (D)</p> Signup and view all the answers

What is the most common adverse effect of clozapine?

<p>Sedation (B)</p> Signup and view all the answers

Which of the following antipsychotic drugs is available in an injectable form?

<p>Fluphenazine and haloperidol (C)</p> Signup and view all the answers

What is a characteristic of haloperidol?

<p>It is a highly potent typical antipsychotic drug with a low incidence of extrapyramidal symptoms (B)</p> Signup and view all the answers

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