Types of Lymphadenitis by Dr. Rasha Samir

Sinus histiocytosis = Sinuses are prominent and lined by hyperplastic sinus histiocytes Mixed patterns in one lymph node = Follicular, diffuse, and sinus patterns coexist in one lymph node Capsule inflammation or fibrosis = Follicular hyperplasia Partial architectural effacement = Marked sinusoidal and capsular changes due to infectious mononucleosis

Acute lymphadenitis = Enlarged painful/tender lymph nodes, redness of overlying skin, low-grade fever, malaise Chronic lymphadenitis = Enlarged lymph nodes by palpation or imaging, painless

Biopsy and clinical history = Diagnosis of chronic lymphadenitis Special stains, electron microscopy, etc. = Identification of specific causative factors

<p>Teenager/young adult with fever, sore throat = Infectious mononucleosis caused by EBV Enlarged painful/tender lymph nodes = Acute lymphadenitis</p> Signup and view all the answers

<p>Reactive lymphoid hyperplasia = Enlarged follicles with mixed small and large lymphocytes Reactive follicular hyperplasia = T cell zones expanded with a population of cells resulting in a starry sky appearance Diffuse paracortical hyperplasia = Enlarged, soft lymph node with tan homogenous cut surfaces Sinus histiocytosis = Proliferation of high endothelial venules</p> Signup and view all the answers

<p>Viruses = Possible cause of reactive lymphadenitis Drugs: phenytoin, allopurinol, atenolol, gold, penicillin, quinidine = Potential inducers of lymph node enlargement Environmental pollutants = One of the multiple etiologic factors for lymphadenitis Fungi = Agent that can lead to hyperplasia of cellular components in lymph nodes</p> Signup and view all the answers

<p>Prominent germinal center and mantle zone = Characteristic feature of reactive follicular hyperplasia Numerous tingible body macrophages = Common in enlarged follicles displaying different configurations Immunoblasts resembling Reed-Sternberg cells = Feature sometimes seen in diffuse paracortical hyperplasia Mitotic figures are frequent = Characteristic finding in reactive follicular hyperplasia</p> Signup and view all the answers

<p>Enlarged, soft, lymph node with tan homogenous cut surfaces = Description matching the term 'Sinus histiocytosis' Star-like or moth eaten appearance = Gross description of 'Diffuse paracortical hyperplasia' Lymph node with varied size and shape follicles = Gross description fitting 'Reactive follicular hyperplasia' Homogeneous cut surfaces with enlarged follicles = Description corresponding to 'Reactive lymphoid hyperplasia'</p> Signup and view all the answers