Types of Eutectic Systems Quiz

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What is the purpose of liquid-assisted grinding (LAG) in cocrystal formation?

To form amorphous phases in the solid state.

To prevent molecular reactions from occurring.

To increase the rate of cocrystal formation. (correct)

To decrease the rate of cocrystal formation.

Which type of molecules are more likely to form cocrystals under mechanochemical conditions by forming amorphous phases?

Molecules with high vapor pressures.

Molecules with weak lattice positions and low reactivity.

Molecules with low melting points.

Molecules with strong lattice positions and substantial hydrogen bonding. (correct)

What kind of solid-based method is hot melt extrusion (HME) for cocrystal formation?

A high-pressure method involving vaporization.

A method using polymer assistance for grinding.

A method for cocrystal formation using heat and pressure. (correct)

A method involving the addition of ionic liquids.

In liquid-assisted grinding, what role does the small amount of liquid play?

It increases the rate of cocrystal formation. (D) Signup and view all the answers

Which type of reactants are suitable for liquid-assisted grinding to form cocrystals?

Reactants with low melting points. (C) Signup and view all the answers

What is the primary difference between liquid-assisted grinding (LAG) and neat grinding in cocrystal formation?

LAG increases the rate of cocrystal formation, while neat grinding does not. (C) Signup and view all the answers

Which of the following is a major advantage of mechanochemical synthesis?

It facilitates fast reaction rates and is environmentally friendly (B) Signup and view all the answers

What is the primary reason for the potential failure of cocrystal formation during dry grinding?

Inability to form crystal arrangement due to poor grinding (D) Signup and view all the answers

Which of the following mechanisms is NOT proposed to describe cocrystallization by solid-state grinding?

Formation of a supersaturated solution (D) Signup and view all the answers

Which grinding method is described as 'neat grinding' in the context of mechanochemical synthesis?

Dry grinding (D) Signup and view all the answers

Which factor should be considered when selecting drugs for cocrystallization using dry grinding?

High melting point (B) Signup and view all the answers

Which of the following is NOT a commonly used process for mechanochemical synthesis mentioned in the text?

Solvent evaporation (B) Signup and view all the answers

What is the main difference between a hydrate/solvate and a cocrystal?

A hydrate/solvate contains one component that exists as a liquid at room temperature, while a cocrystal does not. (D) Signup and view all the answers

What is the purpose of formulating an active pharmaceutical ingredient (API) in its crystalline form?

To improve the stability and ease of administration of the API. (C) Signup and view all the answers

What is polymorphism in the context of solid-state pharmaceuticals?

The ability of a single-component material to exist with different underlying crystal structures. (D) Signup and view all the answers

Which of the following statements about amorphous solids is true?

Amorphous solids do not have a regular repeating array of atoms. (A) Signup and view all the answers

What are Hansen solubility parameters (HSPs) used for in the context of cocrystal formation?

To identify potential cocrystal formers based on their intermolecular interactions. (B) Signup and view all the answers

Which of the following techniques is used for cocrystal screening?

Both solution-based and solid-based crystallization (D) Signup and view all the answers