18 Questions
What is the purpose of liquid-assisted grinding (LAG) in cocrystal formation?
To increase the rate of cocrystal formation.
Which type of molecules are more likely to form cocrystals under mechanochemical conditions by forming amorphous phases?
Molecules with strong lattice positions and substantial hydrogen bonding.
What kind of solid-based method is hot melt extrusion (HME) for cocrystal formation?
A method for cocrystal formation using heat and pressure.
In liquid-assisted grinding, what role does the small amount of liquid play?
It increases the rate of cocrystal formation.
Which type of reactants are suitable for liquid-assisted grinding to form cocrystals?
Reactants with low melting points.
What is the primary difference between liquid-assisted grinding (LAG) and neat grinding in cocrystal formation?
LAG increases the rate of cocrystal formation, while neat grinding does not.
Which of the following is a major advantage of mechanochemical synthesis?
It facilitates fast reaction rates and is environmentally friendly
What is the primary reason for the potential failure of cocrystal formation during dry grinding?
Inability to form crystal arrangement due to poor grinding
Which of the following mechanisms is NOT proposed to describe cocrystallization by solid-state grinding?
Formation of a supersaturated solution
Which grinding method is described as 'neat grinding' in the context of mechanochemical synthesis?
Dry grinding
Which factor should be considered when selecting drugs for cocrystallization using dry grinding?
High melting point
Which of the following is NOT a commonly used process for mechanochemical synthesis mentioned in the text?
Solvent evaporation
What is the main difference between a hydrate/solvate and a cocrystal?
A hydrate/solvate contains one component that exists as a liquid at room temperature, while a cocrystal does not.
What is the purpose of formulating an active pharmaceutical ingredient (API) in its crystalline form?
To improve the stability and ease of administration of the API.
What is polymorphism in the context of solid-state pharmaceuticals?
The ability of a single-component material to exist with different underlying crystal structures.
Which of the following statements about amorphous solids is true?
Amorphous solids do not have a regular repeating array of atoms.
What are Hansen solubility parameters (HSPs) used for in the context of cocrystal formation?
To identify potential cocrystal formers based on their intermolecular interactions.
Which of the following techniques is used for cocrystal screening?
Both solution-based and solid-based crystallization
Test your knowledge on eutectic systems that involve molecules loosely held in lattices and reactants with low melting points. Learn about formation of undercooled or metastable eutectic liquid phases through grinding or energy transfer.
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