Podcast
Questions and Answers
What is the purpose of liquid-assisted grinding (LAG) in cocrystal formation?
What is the purpose of liquid-assisted grinding (LAG) in cocrystal formation?
- To form amorphous phases in the solid state.
- To prevent molecular reactions from occurring.
- To increase the rate of cocrystal formation. (correct)
- To decrease the rate of cocrystal formation.
Which type of molecules are more likely to form cocrystals under mechanochemical conditions by forming amorphous phases?
Which type of molecules are more likely to form cocrystals under mechanochemical conditions by forming amorphous phases?
- Molecules with high vapor pressures.
- Molecules with weak lattice positions and low reactivity.
- Molecules with low melting points.
- Molecules with strong lattice positions and substantial hydrogen bonding. (correct)
What kind of solid-based method is hot melt extrusion (HME) for cocrystal formation?
What kind of solid-based method is hot melt extrusion (HME) for cocrystal formation?
- A high-pressure method involving vaporization.
- A method using polymer assistance for grinding.
- A method for cocrystal formation using heat and pressure. (correct)
- A method involving the addition of ionic liquids.
In liquid-assisted grinding, what role does the small amount of liquid play?
In liquid-assisted grinding, what role does the small amount of liquid play?
Which type of reactants are suitable for liquid-assisted grinding to form cocrystals?
Which type of reactants are suitable for liquid-assisted grinding to form cocrystals?
What is the primary difference between liquid-assisted grinding (LAG) and neat grinding in cocrystal formation?
What is the primary difference between liquid-assisted grinding (LAG) and neat grinding in cocrystal formation?
Which of the following is a major advantage of mechanochemical synthesis?
Which of the following is a major advantage of mechanochemical synthesis?
What is the primary reason for the potential failure of cocrystal formation during dry grinding?
What is the primary reason for the potential failure of cocrystal formation during dry grinding?
Which of the following mechanisms is NOT proposed to describe cocrystallization by solid-state grinding?
Which of the following mechanisms is NOT proposed to describe cocrystallization by solid-state grinding?
Which grinding method is described as 'neat grinding' in the context of mechanochemical synthesis?
Which grinding method is described as 'neat grinding' in the context of mechanochemical synthesis?
Which factor should be considered when selecting drugs for cocrystallization using dry grinding?
Which factor should be considered when selecting drugs for cocrystallization using dry grinding?
Which of the following is NOT a commonly used process for mechanochemical synthesis mentioned in the text?
Which of the following is NOT a commonly used process for mechanochemical synthesis mentioned in the text?
What is the main difference between a hydrate/solvate and a cocrystal?
What is the main difference between a hydrate/solvate and a cocrystal?
What is the purpose of formulating an active pharmaceutical ingredient (API) in its crystalline form?
What is the purpose of formulating an active pharmaceutical ingredient (API) in its crystalline form?
What is polymorphism in the context of solid-state pharmaceuticals?
What is polymorphism in the context of solid-state pharmaceuticals?
Which of the following statements about amorphous solids is true?
Which of the following statements about amorphous solids is true?
What are Hansen solubility parameters (HSPs) used for in the context of cocrystal formation?
What are Hansen solubility parameters (HSPs) used for in the context of cocrystal formation?
Which of the following techniques is used for cocrystal screening?
Which of the following techniques is used for cocrystal screening?
