Types of Connective Tissue Proper

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Questions and Answers

What is the primary function of mucous connective tissue?

  • To provide structural support to bones
  • To store energy in fat cells
  • To give rise to all other connective tissue types (correct)
  • To allow for elasticity in blood vessels

Which of the following features is characteristic of dense connective tissue?

  • High cellularity with numerous fibroblasts
  • Abundant amorphous intercellular material
  • Presence of elastic lamina in blood vessels
  • Close packing of fibers and few cells (correct)

Where is dense white collagen connective tissue found?

  • In the dermis of the skin (correct)
  • In the respiratory tract
  • In the lining of arteries
  • In the brain tissue

What distinguishes regular dense white collagenous connective tissue from irregular dense white collagenous connective tissue?

<p>Fibers arranged in a parallel pattern (B)</p> Signup and view all the answers

What type of tissue is Wharton's jelly classified as?

<p>Mucous connective tissue (C)</p> Signup and view all the answers

Which statement correctly describes the umbilical vein in comparison to the arteries?

<p>It has no internal elastic lamina like the arteries. (D)</p> Signup and view all the answers

What is the main distinguishing characteristic of irregular dense white collagenous connective tissue?

<p>Fibers are arranged in an irregular pattern. (D)</p> Signup and view all the answers

Which tissue type is primarily involved in resisting stretching from multiple directions?

<p>Irregular dense white collagen connective tissue (B)</p> Signup and view all the answers

What is the primary function of the fibrocytes in tendons?

<p>To maintain and repair the tendon structure (C)</p> Signup and view all the answers

What characterizes dense yellow elastic connective tissue?

<p>Ability to return to original length after stretching (A)</p> Signup and view all the answers

Which cells develop into chondrocytes once matured?

<p>Chondroblasts (A)</p> Signup and view all the answers

Which type of loose connective tissue primarily serves as the packing and anchoring material for various structures in the body?

<p>Loose areolar connective tissue (B)</p> Signup and view all the answers

Where are chondrocytes primarily located?

<p>Within the lacunae embedded in cartilage (A)</p> Signup and view all the answers

What distinguishes brown adipose connective tissue from white adipose connective tissue?

<p>Higher vascularity and multiple fat droplets (C)</p> Signup and view all the answers

What distinguishes immature chondrocytes from mature ones?

<p>Immature chondrocytes can divide within lacunae (C)</p> Signup and view all the answers

Where is reticular connective tissue predominantly found?

<p>In lymphoid organs and bone marrow (B)</p> Signup and view all the answers

What is the primary function of cartilage?

<p>To provide flexibility and support (D)</p> Signup and view all the answers

Which of the following tissues contains dense yellow elastic connective tissue?

<p>Ligamentum flavum (B)</p> Signup and view all the answers

Which type of connective tissue is characterized by the presence of undifferentiated mesenchymal cells?

<p>Embryonic mesenchymal connective tissue (C)</p> Signup and view all the answers

Chondroblasts are known for their role in which process?

<p>Cartilage formation (A)</p> Signup and view all the answers

What pigment gives white adipose connective tissue its yellow appearance?

<p>Carotene (A)</p> Signup and view all the answers

Which of the following functions is NOT associated with loose areolar connective tissue?

<p>Fat metabolism (B)</p> Signup and view all the answers

Which characteristic is true of white adipose tissue?

<p>It primarily functions in energy storage. (C)</p> Signup and view all the answers

The main cell types found in loose areolar connective tissue include:

<p>Fibroblasts and macrophages (C)</p> Signup and view all the answers

What type of collagen fibers is primarily found in the matrix of elastic cartilage?

<p>Collagen type II (B)</p> Signup and view all the answers

Which of the following locations is elastic cartilage NOT found?

<p>Pubic symphysis (D)</p> Signup and view all the answers

What characteristic distinguishes fibrocartilage from elastic cartilage?

<p>Presence of perichondrium (C)</p> Signup and view all the answers

What is the primary function of fibrocartilage?

<p>To support against great mechanical stress (B)</p> Signup and view all the answers

Which component primarily nourishes cartilage tissue?

<p>Nutrient diffusion from surrounding tissues (D)</p> Signup and view all the answers

What is the structure surrounding the nucleus pulposus in the intervertebral disc?

<p>Annulus fibrosus (B)</p> Signup and view all the answers

How does cartilage grow by appositional growth?

<p>By adding new layers from the outside (C)</p> Signup and view all the answers

In which condition does the nucleus pulposus herniate through the annulus fibrosus?

<p>Prolapsed intervertebral disc (B)</p> Signup and view all the answers

What is the primary function of osteogenic cells in bone tissue?

<p>To divide and differentiate into other cell types (C)</p> Signup and view all the answers

Which component constitutes the majority of the organic part of bone matrix?

<p>Collagen fibers type I (C)</p> Signup and view all the answers

What is the mineral primarily responsible for the hardness of bone?

<p>Calcium phosphate (D)</p> Signup and view all the answers

Which layer of the periosteum is primarily composed of collagen fibers and fibroblasts?

<p>Outer vascular fibrous layer (B)</p> Signup and view all the answers

What is the function of osteoblasts in bone development?

<p>To mature into osteocytes (B)</p> Signup and view all the answers

What is the composition of the inorganic matrix of bone primarily formed of?

<p>Calcium phosphate (C)</p> Signup and view all the answers

Where are osteogenic cells located within the bone structure?

<p>In the endosteum and periosteum (D)</p> Signup and view all the answers

How do osteogenic cells respond to a highly vascular environment?

<p>They become osteoblasts (D)</p> Signup and view all the answers

What characterizes the appearance of osteoblasts at the EM level?

<p>Prominent Golgi apparatus and abundant ribosomes (B)</p> Signup and view all the answers

What happens to osteoblasts when they become trapped in lacunae?

<p>They differentiate into osteocytes (B)</p> Signup and view all the answers

Which component is synthesized by osteoblasts in the bone matrix?

<p>Collagen fibers type I and glycoproteins (D)</p> Signup and view all the answers

What is the main function of osteocytes in mature bone?

<p>Maintain the bone matrix (D)</p> Signup and view all the answers

What distinguishes osteoclasts from osteoblasts at the LM level?

<p>Osteoclasts possess multiple nuclei and have larger sizes (B)</p> Signup and view all the answers

Which structure is unique to osteoclasts that aids in their function?

<p>Ruffled border (B)</p> Signup and view all the answers

Where can osteoclasts typically be found?

<p>On bony surfaces in Howship's lacunae (A)</p> Signup and view all the answers

What distinguishes the nucleus of osteocytes?

<p>It is central and dark (A)</p> Signup and view all the answers

Flashcards

Loose Connective Tissue

A type of connective tissue with a loose arrangement of cells, fibers, and ground substance.

Areolar Connective Tissue

The most common type of loose connective tissue, containing fibroblasts, macrophages, and collagen fibers.

Adipose Tissue

Loose connective tissue dominated by fat cells, with white and brown types.

White Adipose Tissue

Adipose tissue with fat cells containing a large single fat droplet; a major site of fat storage.

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Brown Adipose Tissue

Adipose tissue with fat cells that store fat in multiple droplets and functions to provide heat.

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Reticular Connective Tissue

Connective tissue with a network of reticular fibers, found in lymphoid organs and other places.

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Embryonic Mesenchymal Connective Tissue

An unspecialized connective tissue of early embryonic development.

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Tendons, Aponeuroses, and Ligaments

These connective tissues share similar histological structures, primarily composed of fibrous tissue.

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Fibrocytes (Tendons)

Specialized cells found primarily in the fibrous component of tendons, eye sclera and cornea .

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Dense Yellow Elastic Connective Tissue

Connective tissue rich in elastic fibers, providing flexibility and recoil.

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Yellow Elastic Ligaments

Ligaments characterized by predominance of elastic fibers, allowing for recoil after stretch.

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Ligamentum Nuchae

Elastic ligament located at the back of the neck.

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Ligamentum Flavum

Elastic ligament positioned between adjacent vertebrae.

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Cartilage

Connective tissue with a firm, flexible, and supportive matrix hardened by intercellular substance.

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Chondroblasts

Immature cartilage-forming cells actively synthesizing matrix components.

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Chondrocytes

Mature cartilage cells, residing in lacunae, responsible for maintaining the matrix.

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Lacunae

Spaces in the cartilage matrix containing chondrocytes.

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Matrix

Solid, intercellular material surrounding cells within connective tissue.

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Mucous Connective Tissue

A type of connective tissue found in the embryo and umbilical cord, composed primarily of stellate fibroblasts, abundant ground substance (mucin), and fine collagenous fibers.

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Wharton's Jelly

The gelatinous mass of mucous connective tissue in the umbilical cord, containing collagen fibers and surrounding the umbilical blood vessels.

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Dense Connective Tissue

Connective tissue characterized by tightly packed fibers and few cells, classified into dense white collagenous and dense yellow elastic types.

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Dense White Collagenous Connective Tissue

Dense connective tissue where collagen fibers are predominant, with two arrangements: regular and irregular.

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Irregular Dense White Collagenous C.T.

Dense connective tissue with collagen fibers arranged haphazardly, withstanding tension in multiple directions, found in skin layers and organ capsules.

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Regular Dense White Collagenous C.T.

Dense connective tissue containing collagen fibers aligned in a parallel pattern, providing tensile strength in one direction; found in tendons and ligaments.

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Tendons

Regular dense connective tissue that connects muscle to bone providing strong attachment and unidirectional force transmission.

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Ligaments

Regular dense connective tissue that connects bone to bone, providing stability and limiting movement.

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Elastic Cartilage

A flexible, semi-rigid cartilage with elastic fibers, enabling it to return to its original shape after deformation.

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Perichondrium

A fibrous membrane covering cartilage, providing nutrients and supporting the growth of cartilage.

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Fibrocartilage

A strong cartilage with collagen fibers, resistant to stretching and compression. It allows restricted mobility under stress.

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Collagen fibers in fibrocartilage

Dense, parallel collagen fibers (type I) providing great strength in fibrocartilage.

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Intervertebral Disc structure

A fibrocartilaginous structure between vertebrae, consisting of an outer annulus fibrosus (collagen type I) and an inner nucleus pulposus (collagen type II).

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Avascular Cartilage

Cartilage lacks its own blood supply; nutrients reach the cells through diffusion or surrounding tissues.

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Appositional Growth (Cartilage)

Growth of cartilage by adding new layers on the surface through chondroblasts in the perichondrium.

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Interstitial Growth

Cartilage growth from within, due to chondrocyte division and matrix secretion.

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Bone Matrix

The non-living material of bone, made of organic and inorganic parts

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Osteoid

Organic part of bone matrix, mostly collagen.

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Bone Mineral

Inorganic part of bone matrix, mainly calcium phosphate.

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Osteogenic Cells

Bone stem cells that can become osteoblasts (bone-building cells).

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Periosteum

Connective tissue covering bone (except joints).

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Endosteum

Inner lining of bone marrow cavities.

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Osteoblasts

Bone-forming cells.

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Osteoblast Function

Osteoblasts are bone-forming cells that synthesize the organic bone matrix (osteoid), including collagen type I and glycoproteins. They also secrete alkaline phosphatase which helps deposit calcium salts.

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Osteoblast Structure (LM)

Osteoblasts appear in periosteum and endosteum, have a deeply basophilic cytoplasm and eccentric nucleus.

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Osteoblast Structure (EM)

Osteoblasts have many ribosomes, abundant RER, a prominent Golgi apparatus, secretory vesicles, and mitochondria, indicating active secretion.

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Osteocyte Function

Osteocytes are mature bone cells that maintain the bone matrix by contributing to the organic portion, such as collagen fibers and proteoglycans. They help exchange nutrients and waste with the bloodstream via canaliculi.

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Osteocyte Structure (LM)

Osteocytes are smaller than osteoblasts, found in lacunae, and their processes extend into canaliculi. They connect with each other through canaliculi.

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Osteocyte Structure (EM)

Osteocytes have a large, dark, central nucleus, and their cytoplasm is rich in mitochondria, ribosomes, RER, and Golgi apparatus.

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Osteoclast Function

Osteoclasts are large cells that break down bone tissue, releasing calcium into the bloodstream. They are located in Howship's lacunae.

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Osteoclast Structure (LM)

Osteoclasts are very large, containing multiple nuclei and acidophilic cytoplasm. Their distinctive location is in Howship's lacunae.

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Osteoclast Structure (EM)

Osteoclasts have abundant lysosomes, mitochondria, and a well-developed Golgi apparatus. The bone-facing surface has a ruffled border, forming compartments for bone breakdown.

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Study Notes

Types of Connective Tissue Proper

  • Connective tissue proper is classified according to matrix density and cell/fiber types.
  • Loose connective tissue includes:
    • Loose areolar connective tissue
    • Adipose connective tissue
    • Reticular connective tissue
    • Embryonic mesenchymal connective tissue
    • Mucous connective tissue
  • Dense connective tissue includes:
    • Dense white collagen connective tissue (irregular and regular)
    • Dense yellow elastic connective tissue

Loose Areolar Connective Tissue

  • Composed of cells, fibers, and ground substance
  • Predominantly white collagenous fibers
  • Functions as packing and anchoring material, embedding medium for nerves/blood vessels, and binding other tissues/organs.
  • Found throughout the body.

Adipose Connective Tissue

  • Two types: white and brown
  • White adipose tissue: Contains one large fat droplet per cell, appearing yellow due to carotene. Primarily for fat metabolism/storage. Found throughout the body
  • Brown adipose tissue: Stores fat in multiple droplets; higher vascularity gives it a brown color. Crucial for heat production in newborns. Found in smaller amounts in adults.

Reticular Connective Tissue

  • Primitive connective tissue with a network of reticular fibers (associated with reticular cells).
  • Creates the framework for many organs (lymph nodes, bone marrow, liver).

Embryonic Mesenchymal Connective Tissue

  • Unspecialized tissue in early embryonic development.
  • Composed of undifferentiated mesenchymal cells, ground substance, and fine reticular fibers.
  • Develops into other connective tissue types.

Mucous Connective Tissue

  • Found in the umbilical cord (Wharton's jelly)
  • Composed of stellate fibroblasts, abundant ground substance (mucin-rich), and fine collagenous fibers.
  • Supports umbilical blood vessels and acts as a gelatinous substance.

Dense Connective Tissue

  • Characterized by the close packing of fibers, few cells, and little ground substance.
  • Classified based on fiber type (collagen or elastic).

Dense White Collagen Connective Tissue

  • Irregular: Collagen fibers in various directions. Found in dermis, capsules, and around organs.
  • Regular: Collagen fibers in parallel arrangement. Found in tendons and ligaments.

Dense Yellow Elastic Connective Tissue

  • Predominantly composed of elastic fibers, providing elasticity/ability to return to original shape.
  • Located in ligaments, like ligamentum nuchae and flavum, and walls of large arteries.

Cartilage

  • Firm, flexible, and strong connective tissue
  • Unlike bone, it lacks blood vessels so nutrients are delivered through diffusion.
  • Made up of cells, fibers, and extracellular matrix.
  • Cells: Chondroblasts and chondrocytes
  • Fibers: Collagen fibers (mostly type II)
  • Matrix: Ground substance (cartilage matrix), chondroitin sulfate, glycoproteins, water

Chondroblasts

  • Active cartilage-forming cells.
  • Synthesize collagen fibers and the matrix, producing new cartilage matrix.
  • Located in the inner portion of the perichondrium.
  • Once enclosed in lacunae they are called chondrocytes.

Chondrocytes

  • Mature cartilage cells.
  • Inside cartilage lacunae.
  • Maintain the cartilage matrix.
  • Can divide, creating cell nests of two, four, or more cells.

Cartilage Fibers

  • Collagen fibers (primarily type II)
  • Elastic fibers (present in elastic cartilage only)

Cartilage Matrix

  • Ground substance rich in water & proteins (proteoglycans, chondromucoprotein, chondroitin sulfate).
  • Provides resilience and support.

Types of Cartilage

  • Hyaline: Most common type; smooth surface for joint articulation; found in articular surfaces, respiratory tracts.
  • Elastic: Flexible; ear, epiglottis
  • Fibrocartilage: Strongest; intervertebral discs, pubic symphysis.

Bone

  • Strong, hard, rigid connective tissue. Matrix composed of organic components (osteoid) and inorganic components (bone mineral).
  • Matrix has collagen fibers, ground substance, water

Osteogenic Cells

  • Mesenchymal stem cells
  • Located in periosteum & endosteum
  • Can differentiate into osteoblasts and chondroblasts.

Osteoblasts

  • Bone-forming cells
  • Synthesize and secrete organic components (osteoid)
  • When trapped in matrix, differentiate into osteocytes (mature bone cells)

Osteocytes

  • Mature bone cells residing in lacunae within the bone matrix.
  • Maintain bone matrix and communicate with other osteocytes.

Osteoclasts

  • Bone-resorbing cells
  • Responsible for breaking down and remodeling bone tissue.

Cartilage Nutrition

  • Cartilage is avascular; nutrients, oxygen diffuse through matrix from perichondrium.

Cartilage Growth

  • Appositional: New layers added from perichondrium surface.
  • Interstitial: Growth from within the tissue, due to chondrocyte division.

Clinical Note - Herniated Intervertebral Disc

  • Prolapsed disc: Nucleus pulposus (disc's soft core) herniates through annulus fibrosus (outer ring).
  • Causes inflammation and pain; potentially compresses spinal nerves.

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