18 Questions
Which type of pili are found in bacteria such as P.aeruginosa and N.gonorrhoeae?
Type IV pili
What do type IV pili bind to on epithelial cell surfaces?
Glycolipids
Which term describes the surface proteins that bind to specific receptor molecules on host cells?
Adhesins
What do MSCRAMMs stand for in the context of bacterial adhesion?
Microbial surface components recognising adhesive matrix molecules
Which mechanism is involved in the binding of MSCRAMMs to their ligands?
'Dock lock latch'
What is the role of type IV pili in Pseudomonas and Neisseria according to the text?
Biofilm formation
Why is adhesion critical for bacterial pathogens?
To evade immune defenses and adhere to different cell types
What is the purpose of pili (fimbriae) in host cell adherence?
To depolymerize and make intimate contact with host cells
What is the role of adhesins in biofilm formation?
To serve as a trigger for synthesizing additional cell wall adhesins
What makes biofilms more resistant to antibiotics and immune defenses compared to planktonic bacteria?
Formation of multicellular communities
Why do bacteria constantly lose and reform pili?
To evade immune defenses by switching adhesive tips
What is the function of the shaft end of pili in host cell adherence?
Attaching to specific receptors on host cells
What is the role of the FimH adhesin in UPEC?
Recognizes mannose on mannosylated proteins of the bladder epithelium
Which statement about the fim operon in UPEC is true?
Encodes type 1 pili and expresses hemagglutinin
What is the function of PapG in P pili of UPEC?
Represents the actual adhesin
Which statement accurately describes Type IV pili?
Enable twitching motility along a solid surface
What happens when mutants lack type 1 pili or FimH adhesin in UPEC?
They are quickly cleared from the bladder
What is the primary function of the PapK subunit in P pili of UPEC?
Connects above subunits to the PapA pilus rod
Test your knowledge on bacteria with type IV pili, including P. aeruginosa, N. gonorrhoeae, Neisseria meningitidis, and V. cholerae. Learn about the structure, assembly, and binding properties of type IV pili.
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