Type IV Pili in Bacteria Quiz

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Questions and Answers

Which type of pili are found in bacteria such as P.aeruginosa and N.gonorrhoeae?

  • Type III pili
  • Type I pili
  • Type IV pili (correct)
  • Type II pili

What do type IV pili bind to on epithelial cell surfaces?

  • Carbohydrates
  • Proteins
  • Glycolipids (correct)
  • Nucleic acids

Which term describes the surface proteins that bind to specific receptor molecules on host cells?

  • Enzymes
  • Flagella
  • Adhesins (correct)
  • Pili

What do MSCRAMMs stand for in the context of bacterial adhesion?

<p>Microbial surface components recognising adhesive matrix molecules (A)</p> Signup and view all the answers

Which mechanism is involved in the binding of MSCRAMMs to their ligands?

<p>'Dock lock latch' (A)</p> Signup and view all the answers

What is the role of type IV pili in Pseudomonas and Neisseria according to the text?

<p>Biofilm formation (C)</p> Signup and view all the answers

Why is adhesion critical for bacterial pathogens?

<p>To evade immune defenses and adhere to different cell types (B)</p> Signup and view all the answers

What is the purpose of pili (fimbriae) in host cell adherence?

<p>To depolymerize and make intimate contact with host cells (C)</p> Signup and view all the answers

What is the role of adhesins in biofilm formation?

<p>To serve as a trigger for synthesizing additional cell wall adhesins (C)</p> Signup and view all the answers

What makes biofilms more resistant to antibiotics and immune defenses compared to planktonic bacteria?

<p>Formation of multicellular communities (C)</p> Signup and view all the answers

Why do bacteria constantly lose and reform pili?

<p>To evade immune defenses by switching adhesive tips (C)</p> Signup and view all the answers

What is the function of the shaft end of pili in host cell adherence?

<p>Attaching to specific receptors on host cells (B)</p> Signup and view all the answers

What is the role of the FimH adhesin in UPEC?

<p>Recognizes mannose on mannosylated proteins of the bladder epithelium (C)</p> Signup and view all the answers

Which statement about the fim operon in UPEC is true?

<p>Encodes type 1 pili and expresses hemagglutinin (D)</p> Signup and view all the answers

What is the function of PapG in P pili of UPEC?

<p>Represents the actual adhesin (D)</p> Signup and view all the answers

Which statement accurately describes Type IV pili?

<p>Enable twitching motility along a solid surface (B)</p> Signup and view all the answers

What happens when mutants lack type 1 pili or FimH adhesin in UPEC?

<p>They are quickly cleared from the bladder (C)</p> Signup and view all the answers

What is the primary function of the PapK subunit in P pili of UPEC?

<p>Connects above subunits to the PapA pilus rod (B)</p> Signup and view all the answers

Flashcards

Type IV Pili

Type IV pili are found in bacteria such as Pseudomonas aeruginosa and Neisseria gonorrhoeae.

Type IV Pili Binding

Type IV pili bind to glycolipids on epithelial cell surfaces.

Adhesins

Surface proteins that bind to specific receptor molecules on host cells.

MSCRAMMs

Microbial surface components recognizing adhesive matrix molecules.

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'Dock lock latch' Mechanism

The mechanism involved in the binding of MSCRAMMs to their ligands.

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Type IV Pili Role

Type IV pili in Pseudomonas and Neisseria are involved in biofilm formation.

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Importance of Adhesion

Adhesion is critical for bacterial pathogens because it helps them evade immune defenses and adhere to different cell types.

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Pili (fimbriae) purpose

Pili (fimbriae) purpose in host cell adherence is to depolymerize and make intimate contact with host cells

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Adhesins Role in Biofilm Formation

Adhesins in biofilm formation serve as a trigger for synthesizing additional cell wall adhesins.

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Biofilm Resistance

Formation of multicellular communities makes biofilms more resistant to antibiotics and immune defenses compared to planktonic bacteria.

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Pili Dynamics

Bacteria constantly lose and reform pili to evade immune defenses by switching adhesive tips.

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Pili Shaft Function

The shaft end of pili attaches to specific receptors on host cells.

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FimH Adhesin Role

FimH adhesin in UPEC recognizes mannose on mannosylated proteins of the bladder epithelium.

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fim Operon in UPEC

The fim operon encodes type 1 pili and expresses hemagglutinin.

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PapG Function

PapG represents the actual adhesin.

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Type IV Pili Function

Type IV pili enable twitching motility along a solid surface.

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Consequence of Pili/Adhesin Deficiency

Mutants that lack type 1 pili or FimH adhesin in UPEC are quickly cleared from the bladder.

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PapK Subunit Function

The PapK subunit connects above subunits to the PapA pilus rod.

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