Podcast
Questions and Answers
What is the epitope targeted by T cells in Type 1 diabetes?
What is the epitope targeted by T cells in Type 1 diabetes?
Which peptide from Parabacteroides distasonis activated T cells specific to insB:9–23 in T1D patients and NOD mice?
Which peptide from Parabacteroides distasonis activated T cells specific to insB:9–23 in T1D patients and NOD mice?
What effect did colonization with P. distasonis have on the development of T1D in female NOD mice?
What effect did colonization with P. distasonis have on the development of T1D in female NOD mice?
What was observed in the sera of NOD mice colonized with P. distasonis and human T1D patients?
What was observed in the sera of NOD mice colonized with P. distasonis and human T1D patients?
Signup and view all the answers
What effect did colonization with P. distasonis have on the development of T1D in female NOD mice?
What effect did colonization with P. distasonis have on the development of T1D in female NOD mice?
Signup and view all the answers
What is the epitope targeted by T cells in Type 1 diabetes?
What is the epitope targeted by T cells in Type 1 diabetes?
Signup and view all the answers
Which peptide from Parabacteroides distasonis activated T cells specific to insB:9–23 in T1D patients and NOD mice?
Which peptide from Parabacteroides distasonis activated T cells specific to insB:9–23 in T1D patients and NOD mice?
Signup and view all the answers
What was observed in the sera of NOD mice colonized with P. distasonis and human T1D patients?
What was observed in the sera of NOD mice colonized with P. distasonis and human T1D patients?
Signup and view all the answers
Which cell type decreased in female NOD mice colonized with P. distasonis, contributing to the acceleration of T1D development?
Which cell type decreased in female NOD mice colonized with P. distasonis, contributing to the acceleration of T1D development?
Signup and view all the answers
What was the effect of adoptive transfer of splenocytes from P. distasonis–treated mice to NOD/SCID mice?
What was the effect of adoptive transfer of splenocytes from P. distasonis–treated mice to NOD/SCID mice?
Signup and view all the answers
What was identified in the sera of NOD mice colonized with P. distasonis and human T1D patients?
What was identified in the sera of NOD mice colonized with P. distasonis and human T1D patients?
Signup and view all the answers
Which peptide from Parabacteroides distasonis activated T cells specific to insB:9–23 in T1D patients and NOD mice?
Which peptide from Parabacteroides distasonis activated T cells specific to insB:9–23 in T1D patients and NOD mice?
Signup and view all the answers
