Tumor Markers and Cancer Diagnosis
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Questions and Answers

Which marker is used primarily for follow-up and not early diagnosis of ovarian carcinoma?

  • CA-125 (correct)
  • AFP
  • PSA
  • CEA
  • Markers of host response to tumor are characterized by which two features?

  • Low sensitivity and low specificity (correct)
  • Low sensitivity and high specificity
  • High sensitivity and low specificity
  • High sensitivity and high specificity
  • Steroid receptors bind which of the following hormones in malignant breast tissues?

  • Estrogen and progesterone (correct)
  • Thyroxine and glucagon
  • Cortisol and prolactin
  • Testosterone and insulin
  • Which type of tumor marker is used exclusively through tumor tissue biopsy?

    <p>Cellular markers related to prognosis</p> Signup and view all the answers

    Uric acid is an example of which type of biochemical marker?

    <p>Product of metabolism</p> Signup and view all the answers

    The presence of steroid receptors in malignant breast tissues is an indicator of what?

    <p>Good response to endocrine therapy</p> Signup and view all the answers

    Study Notes

    Tumor Markers

    • Cell Surface Glycoproteins and Mucins:
      • Used for follow-up of certain tumors, not for early diagnosis
      • Example: CA-125 is used in ovarian carcinoma

    Markers of Host Response to Tumor:

    • Characterized by low sensitivity and specificity
    • May be the only biochemical markers for follow-up in some tumors
    • Examples:
      • Acute phase reactants, such as α1 acid glycoprotein and c-reactive protein
      • Products of metabolism, such as uric acid
    • Detected only on tumor tissue biopsy
    • Related to prognosis of tumors

    Steroid Receptors:

    • Cytoplasmic receptors that bind estrogen and progesterone
    • Present in normal and malignant breast tissues
    • Higher percentage found in postmenopausal women
    • Presence in malignant breast tissues indicates good response to endocrine therapy

    Genes and Nucleic Acid:

    • Patterns of genes or alterations in nucleic acid structures used for tumor detection
    • Specifically, looks at changes in genes or nucleic acid structures that occur in certain tumors

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    Description

    This quiz covers tumor markers, including cell surface glycoproteins, mucins, and markers of host response to tumor. Learn about their uses and limitations in cancer diagnosis and follow-up.

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