Tuberculosis Spread of Infection and Organ Affection
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Questions and Answers

What is the basic lesion of tuberculosis?

  • Proliferative tissue reaction (correct)
  • Hypersensitivity reaction
  • Exudative tissue reaction
  • Localized fibrosis

How does the mechanism of caseation occur in tuberculosis?

  • Fibrous replacement
  • Cytotoxic lymphokines (correct)
  • Ischemic necrosis
  • Exudative tissue reaction

Which route is NOT a mechanism for the spread of tuberculosis?

  • Blood spread leading to isolated organ tuberculosis
  • Direct spread to the surroundings
  • Lymphatic spread to the draining lymph nodes
  • Neurological spread to the central nervous system (correct)

What type of immunity is mainly responsible for influencing the course of tuberculosis?

<p>Innate immunity (D)</p> Signup and view all the answers

What characterizes secondary tuberculosis reinfection?

<p>Spread of infection is more common (D)</p> Signup and view all the answers

Where does primary pulmonary tuberculosis commonly develop?

<p>In the lungs (B)</p> Signup and view all the answers

What is the main cause of tuberculosis?

<p>Bacteria and their toxins (C)</p> Signup and view all the answers

Which of the following is NOT a predisposing factor for tuberculosis?

<p>Excess heat and cold (B)</p> Signup and view all the answers

What type of bacteria causes tuberculosis?

<p>Gram-positive, acid-fast bacilli (D)</p> Signup and view all the answers

Which of the following is a non-living irritant that can cause cell injury?

<p>Excess heat (A)</p> Signup and view all the answers

What stain is best used to visualize tubercle bacilli?

<p>Ziehl-Neelsen stain (D)</p> Signup and view all the answers

What is the most common source of infection for tuberculosis of bone?

<p>Blood-borne transmission (B)</p> Signup and view all the answers

Which of the following is a characteristic feature of tertiary syphilis?

<p>Syphilitic gumma and diffuse lesions (B)</p> Signup and view all the answers

What is the pathogenesis of granulomatous reaction in bilharziasis caused by schistosoma mansoni?

<p>Granulomatous reaction due to T-lymphocytes (D)</p> Signup and view all the answers

Which of the following is a microscopic feature of sarcoidosis?

<p>Schaumann bodies (C)</p> Signup and view all the answers

What is the best method for demonstrating fungi in tissues?

<p>PAS stain (B)</p> Signup and view all the answers

What is a common characteristic of granulomas in chronic inflammation?

<p>Nodular collections of modified macrophages (A)</p> Signup and view all the answers

Which type of fungal infection can invade widely and cause systemic disease?

<p>Deep fungal infections (D)</p> Signup and view all the answers

What is the famous name for mycetoma pedis?

<p>Madura foot (D)</p> Signup and view all the answers

What is the most common manifestation of superficial candidiasis?

<p>White oral mucosal patches composed of fungal colonies (A)</p> Signup and view all the answers

Which condition can lead to the pathogenicity of Candida albicans?

<p>Prolonged broad spectrum antibiotic therapy (D)</p> Signup and view all the answers

What represents an example of chronic non-specific inflammation?

<p>Syphilis (C)</p> Signup and view all the answers

What is the mechanism of Type I hypersensitivity?

<p>Introduction of antigen for the first time stimulates IgE formation (A)</p> Signup and view all the answers

Which of the following is NOT a possible route of bronchial spread in tuberculosis?

<p>Ingestion of infected sputum causing secondary intestinal tuberculosis (A)</p> Signup and view all the answers

Which of the following is a characteristic feature of primary complex in tuberculosis?

<p>Enlarged mesenteric lymph nodes with caseating tubercles (B)</p> Signup and view all the answers

What is the fate of primary tuberculosis of tonsils?

<p>Hematogenous spread leading to isolated organ or miliary tuberculosis (B)</p> Signup and view all the answers

What is the main cause of secondary pulmonary tuberculosis?

<p>Reinfection through inhalation or ingestion (B)</p> Signup and view all the answers

Which clinical feature is characteristic of chronic fibrocaseous tuberculosis?

<p>Rupture of cavity into the pleural sac causing pneumothorax (B)</p> Signup and view all the answers

What is a possible complication of secondary tuberculosis of the intestine?

<p>Intestinal hemorrhage and intestinal fistulae (A)</p> Signup and view all the answers

Which type of hypersensitivity reaction involves the production of IgE localized within a certain tissue or organ?

<p>Type I (D)</p> Signup and view all the answers

What is the mechanism of Type II hypersensitivity reaction?

<p>The target cells undergo lysis due to complement activation. (C)</p> Signup and view all the answers

Which condition is an example of Type III hypersensitivity reaction?

<p>Acute proliferative post-streptococcal glomerulonephritis (A)</p> Signup and view all the answers

Which type of hypersensitivity reaction leads to cell-mediated graft rejection?

<p>Type IV (C)</p> Signup and view all the answers

What characterizes collagen diseases such as systemic lupus erythematosus (SLE)?

<p>Pathology resembling a mass of fibrin accompanied by inflammation (C)</p> Signup and view all the answers

Which autoimmune disease results from the destruction of collagen within and around vessels?

<p>Scleroderma (B)</p> Signup and view all the answers

What are some examples of endocrine diseases caused by autoimmune reactions?

<p>1ry myxoedema, 1ry Addison’s disease, male infertility (C)</p> Signup and view all the answers

What is the mechanism of Type IV hypersensitivity reaction?

<p>The antigen stimulates T lymphocytes which then cause necrosis. (B)</p> Signup and view all the answers

What leads to the production of autoantibodies in autoimmune diseases?

<p>Imbalance of suppressor-helper T cell function (A)</p> Signup and view all the answers

What is the hallmark of collagen diseases?

<p>Fibrosis resulting from injury to collagen within and around vessels (D)</p> Signup and view all the answers

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