Podcast
Questions and Answers
Which enzyme catalyzes the formation of Acyl-CoA during the activation of fatty acids?
Which enzyme catalyzes the formation of Acyl-CoA during the activation of fatty acids?
Which hormone reduces the hydrolysis of triacylglycerols?
Which hormone reduces the hydrolysis of triacylglycerols?
Melanocyte-stimulating hormone (MSH) promotes lipolysis by activating which enzyme?
Melanocyte-stimulating hormone (MSH) promotes lipolysis by activating which enzyme?
Perilipin is involved in which of the following functions?
Perilipin is involved in which of the following functions?
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Which of the following hormones is NOT involved in the promotion of lipolysis?
Which of the following hormones is NOT involved in the promotion of lipolysis?
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The degradation of phospholipids is primarily performed by which enzyme?
The degradation of phospholipids is primarily performed by which enzyme?
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Which of the following is a location where phospholipase can be found?
Which of the following is a location where phospholipase can be found?
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Pathogenic bacteria produce phospholipase to achieve what effect?
Pathogenic bacteria produce phospholipase to achieve what effect?
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Study Notes
Control of Triacylglycerols Metabolism
- Triacylglycerols are stored in adipose tissue lipid droplets and undergo continuous lipolysis and biosynthesis.
- Two main factors regulate the rate of triacylglycerol synthesis and degradation: hormones and perilipin.
Hormonal Regulation
- Insulin stimulates triacylglycerol biosynthesis and reduces hydrolysis.
- Several hormones promote lipolysis by activating hormone-sensitive lipase, including:
- Epinephrine
- Norepinephrine
- Glucagon
- Adrenocorticotropic hormone (ACTH)
- Melanocyte-stimulating hormones (MSH)
- Thyroid-stimulating hormone (TSH)
- Growth hormone (GH)
Perilipin Regulation
- Perilipin is a protein involved in lipid droplet formation in adipocytes, enabling coordinated storage and breakdown of triacylglycerol according to metabolic needs.
Metabolism of Phospholipids
- Phospholipid metabolism involves hydrolysis and biosynthesis, with a focus on hydrolysis.
Hydrolysis of Phospholipids
- Phospholipase enzyme degrades phospholipids and is found in:
- All tissues
- Pancreatic juice
- Toxins
- Pathogenic bacteria (to dissolve cell membranes and spread infection)
- Lysosomes
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Description
Learn about the regulation of triacylglycerols metabolism, including the role of hormones and perilipin in lipolysis and biosynthesis.
