8 Questions
Which of the following PAMORAS is administered via injection?
Methylnaltrexone
Which PAMORAS is indicated for opioid-induced constipation in patients with chronic non-cancer pain, and has a dosing of 0.2 mg daily?
Naldemedine
What is a key contraindication for the use of PAMORAS like Methylnaltrexone?
GI obstruction
What is a common side effect of Methylnaltrexone?
Abdominal pain
Which PAMORAS should be dosed at 25 mg once daily in the morning on an empty stomach for a patient with opioid-induced constipation and chronic non-cancer pain?
Naloxegol
What is the dosing for Lubiprostone in the treatment of opioid-induced constipation?
24 mcg BID
Which of the following drugs should be avoided or used at a reduced dose with CYP3A4 inhibitors?
Naloxegol
Which precaution is common across PAMORAS like Methylnaltrexone, Naloxegol, and Naldemedine?
Monitor for severe abdominal symptoms due to risk of GI perforation
Study Notes
Treatment of Opioid-Induced Constipation (OIC)
- Peripherally-acting mu-opioid receptor antagonists (PAMORAS) are used to treat OIC.
- PAMORAS work by blocking opioid receptors in the gut to reduce constipation.
- PAMORAS do not affect analgesia, which means they do not reduce the pain-relieving effects of opioids.
- PAMORAS are only effective when constipation is caused by the use of opioids.
Drug Dosing and Safety
- PAMORAS have specific dosing regimens.
- Patients taking PAMORAS must be monitored for side effects and safety.
- The safety and side effects of PAMORAS vary depending on the specific drug used.
This quiz covers the treatment of Opioid-Induced Constipation (OIC) using Peripherally-acting mu-opioid receptor antagonists (PAMORAS), including their mechanism of action and dosing regimens.
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