Podcast
Questions and Answers
Which condition is associated with severe organ dysfunction?
Which condition is associated with severe organ dysfunction?
- Acute sinusitis
- Renal failure (correct)
- Seasonal allergies
- Hemophilia
What is the most common laboratory finding associated with the condition described?
What is the most common laboratory finding associated with the condition described?
- Thrombocytopenia (correct)
- Eosinophilia
- Leukopenia
- Neutrophilia
What is a less common condition mentioned that can occur due to disseminated intravascular coagulopathy?
What is a less common condition mentioned that can occur due to disseminated intravascular coagulopathy?
- Pulmonary embolism
- Hepatic fibrosis
- Pericardial effusion (correct)
- Chronic cough
Which of the following is a potential consequence of the condition in utero?
Which of the following is a potential consequence of the condition in utero?
Which of the following is a symptom associated with ascites?
Which of the following is a symptom associated with ascites?
Which laboratory finding indicates liver involvement in the described condition?
Which laboratory finding indicates liver involvement in the described condition?
What condition reflects severe dysfunction of the hepatic system?
What condition reflects severe dysfunction of the hepatic system?
Which of the following is NOT a characteristic finding in the laboratory results?
Which of the following is NOT a characteristic finding in the laboratory results?
Which condition is the rarest form of organ failure mentioned?
Which condition is the rarest form of organ failure mentioned?
What is the relevance of bone marrow examination in the context described?
What is the relevance of bone marrow examination in the context described?
What type of observations are described in the content?
What type of observations are described in the content?
Which of the following disorders are mentioned as being associated with non-specific observations?
Which of the following disorders are mentioned as being associated with non-specific observations?
Which process is NOT mentioned in connection with the non-specific observations?
Which process is NOT mentioned in connection with the non-specific observations?
What is a characteristic of the observations discussed?
What is a characteristic of the observations discussed?
Which statement best describes the context of the observations?
Which statement best describes the context of the observations?
Which of the following is a poor prognostic factor for early death?
Which of the following is a poor prognostic factor for early death?
What elevated laboratory finding is associated with poor prognosis for early death?
What elevated laboratory finding is associated with poor prognosis for early death?
Which of the following factors does NOT indicate a poor prognosis for early death?
Which of the following factors does NOT indicate a poor prognosis for early death?
Among the following, which finding is indicative of a poor prognosis for early mortality?
Among the following, which finding is indicative of a poor prognosis for early mortality?
Which of these conditions is associated with an adverse prognosis for early death?
Which of these conditions is associated with an adverse prognosis for early death?
What antigen is positively expressed in the blast population of AML and TAM in DS patients?
What antigen is positively expressed in the blast population of AML and TAM in DS patients?
Which antigens are negatively expressed in the blast population of AML and TAM in DS patients?
Which antigens are negatively expressed in the blast population of AML and TAM in DS patients?
What similarity is observed between the blast population of AML and TAM in DS patients based on immunophenotyping?
What similarity is observed between the blast population of AML and TAM in DS patients based on immunophenotyping?
Which of the following antigens indicates megakaryocytic differentiation in the studied populations?
Which of the following antigens indicates megakaryocytic differentiation in the studied populations?
What technique was used to perform the immunophenotyping study in DS patients?
What technique was used to perform the immunophenotyping study in DS patients?
Study Notes
Clinical Manifestations of Transient Myeloproliferative Disorder (TAM)
- Can be observed in other disorders like trisomy 15 and 13, leukemias, inflammatory processes, chemotherapy.
- Possible symptoms: ascites, pericardial or pleural effusions, hepatic fibrosis, disseminated intravascular coagulopathy (DIC), renal, hepatic or cardiopulmonary failure, and hydrops fetalis.
Laboratory Findings of TAM
- Presence of megakaryoblasts in peripheral blood.
- Thrombocytopenia is the most common finding.
- Moderate leukocytosis with myeloid left shift.
- Basophilia is present.
- Coagulopathy, specifically DIC (10%).
- Elevated conjugated bilirubin, secondary to liver involvement.
- Bone marrow examination is not necessary but often done to rule out leukemia.
Prognostic Factors of TAM
- Poor prognostic factors for early death include:
- High WBC count.
- Increased bilirubin.
- Elevated liver function tests (LFTs).
- Failure to normalize blood counts.
Immunophenotyping Study of TAM
- Immunophenotyping study using multiparameter flow cytometry in TAM and Acute Myeloid Leukemia (AML) in Down syndrome patients suggests that the blast population shares similar characteristics:
- Positive reaction for CD45, CD33, CD41, CD61, CD34.
- Negative reaction for CD14 and CD64 antigens, indicating megakaryocytic differentiation.
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Description
This quiz explores the clinical manifestations, laboratory findings, and prognostic factors associated with Transient Myeloproliferative Disorder (TAM). Participants will gain insights into the symptoms, laboratory results, and outcomes related to this condition. Perfect for medical students or professionals looking to deepen their understanding of TAM.
