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Questions and Answers
What is the name of the transcription factors that can be used to obtain a specific type of cell from fibroblastic cells?
What is the name of the transcription factors that can be used to obtain a specific type of cell from fibroblastic cells?
- Yamanaki Factors (correct)
- Cancer Inducing Factors
- Reprogramming Factors
- Stem Cell Factors
How can the activity of a transcription factor be regulated?
How can the activity of a transcription factor be regulated?
- By changing the level of the transcription factor only
- By changing post translational modifications only
- By changing the level of the transcription factor and by changing post translational modifications (correct)
- By binding of ligand to a ligand binding pocket only
What is a way in which transcription factors can cooperate in activating a specific gene?
What is a way in which transcription factors can cooperate in activating a specific gene?
- By binding to the promoter of the gene
- By inhibiting each other
- By binding to the same enhancer
- By binding to different enhancers that each interact with and activate the promoter (correct)
What is a characteristic of transcription factor c-Myc in cancer cells?
What is a characteristic of transcription factor c-Myc in cancer cells?
How can transcription factors antagonize each other?
How can transcription factors antagonize each other?
What is a potential application of cells obtained by forcing fibroblastic cells to overexpress specific transcription factors?
What is a potential application of cells obtained by forcing fibroblastic cells to overexpress specific transcription factors?
What modification of histone tails is generally associated with repressive chromatin?
What modification of histone tails is generally associated with repressive chromatin?
In which type of chromatin are cytosines in CpGs generally methylated?
In which type of chromatin are cytosines in CpGs generally methylated?
What is responsible for spreading repressive chromatin marks to neighboring regions in chromatin?
What is responsible for spreading repressive chromatin marks to neighboring regions in chromatin?
Which mechanism ensures the maintenance of histone marks after DNA replication?
Which mechanism ensures the maintenance of histone marks after DNA replication?
How are eukaryotic transcription factors known to regulate the activity of a specific gene?
How are eukaryotic transcription factors known to regulate the activity of a specific gene?
In the context of transcription factor cooperation, how do different transcription factors work together to activate a specific gene?
In the context of transcription factor cooperation, how do different transcription factors work together to activate a specific gene?
What is one way transcription factors can cooperate?
What is one way transcription factors can cooperate?
In a loss-of-function experiment, what is the purpose of transfecting cells with siRNA targeting c-Myc?
In a loss-of-function experiment, what is the purpose of transfecting cells with siRNA targeting c-Myc?
What can repressive transcription factors recruit to influence gene expression?
What can repressive transcription factors recruit to influence gene expression?
How can genes be silenced without changing the DNA sequence?
How can genes be silenced without changing the DNA sequence?
What effect can high expression of Yamanaki factors have on a fibroblastic cell?
What effect can high expression of Yamanaki factors have on a fibroblastic cell?
How can transcription factors negatively affect each other?
How can transcription factors negatively affect each other?
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