Transcription Factors, Yamanaka Factors, and Cell Reprogramming Quiz

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What is the name of the transcription factors that can be used to obtain a specific type of cell from fibroblastic cells?

Yamanaki Factors (correct)

Cancer Inducing Factors

Reprogramming Factors

Stem Cell Factors

How can the activity of a transcription factor be regulated?

By changing the level of the transcription factor only

By changing post translational modifications only

By changing the level of the transcription factor and by changing post translational modifications (correct)

By binding of ligand to a ligand binding pocket only

What is a way in which transcription factors can cooperate in activating a specific gene?

By binding to the promoter of the gene

By inhibiting each other

By binding to the same enhancer

By binding to different enhancers that each interact with and activate the promoter (correct)

What is a characteristic of transcription factor c-Myc in cancer cells?

It is expressed at high levels Signup and view all the answers

How can transcription factors antagonize each other?

In different ways, depending on the specific transcription factors involved Signup and view all the answers

What is a potential application of cells obtained by forcing fibroblastic cells to overexpress specific transcription factors?

Biomedical research and therapy Signup and view all the answers

What modification of histone tails is generally associated with repressive chromatin?

Methylation Signup and view all the answers

In which type of chromatin are cytosines in CpGs generally methylated?

Repressive chromatin Signup and view all the answers

What is responsible for spreading repressive chromatin marks to neighboring regions in chromatin?

Rewriter proteins Signup and view all the answers

Which mechanism ensures the maintenance of histone marks after DNA replication?

Spreading of existing marks Signup and view all the answers

How are eukaryotic transcription factors known to regulate the activity of a specific gene?

By binding to and modulating the RNA polymerase activity Signup and view all the answers

In the context of transcription factor cooperation, how do different transcription factors work together to activate a specific gene?

By interacting with different parts of the promoter region Signup and view all the answers

What is one way transcription factors can cooperate?

They help each other to bind to the same enhancer Signup and view all the answers

In a loss-of-function experiment, what is the purpose of transfecting cells with siRNA targeting c-Myc?

To silence the c-Myc gene Signup and view all the answers

What can repressive transcription factors recruit to influence gene expression?

Repressive marks on histones Signup and view all the answers

How can genes be silenced without changing the DNA sequence?

By adding methyl groups to DNA Signup and view all the answers

What effect can high expression of Yamanaki factors have on a fibroblastic cell?

Reprogramming into an induced pluripotent stem cell Signup and view all the answers

How can transcription factors negatively affect each other?

By competing for the same binding site Signup and view all the answers

Transcription Factors, Yamanaka Factors, and Cell Reprogramming Quiz

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