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Questions and Answers
Which of the following tissues is particularly associated with high activity of transaminases?
Which of the following tissues is particularly associated with high activity of transaminases?
What is the main function of transaminases in amino acid metabolism?
What is the main function of transaminases in amino acid metabolism?
Which enzyme is predominantly found in the liver and serves as an indicator of liver injury?
Which enzyme is predominantly found in the liver and serves as an indicator of liver injury?
What does the general reaction of transamination involve?
What does the general reaction of transamination involve?
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Which statement about serum aspartate transaminase (AST) is correct?
Which statement about serum aspartate transaminase (AST) is correct?
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Study Notes
Transamination Reactions
- Transamination reactions combine reversible amination and deamination, mediating the redistribution of amino groups among amino acids.
- These reactions involve the transfer of amino groups from amino acids to α-keto acids, resulting in the formation of new amino acids and α-keto acids.
Transaminases
- Transaminases (also known as aminotransferases) are widely distributed in human tissues, with high activity in heart muscle, liver, skeletal muscle, and kidney.
- Different enzymes are involved in transamination reactions, depending on the specific amino acid and α-keto acid involved.
Examples of Transaminases
Aspartate Transaminase (AST)
- Aspartate transaminase (AST) is an example of a transaminase enzyme.
- AST is involved in transamination reactions, specifically converting aspartate and α-ketoglutarate to oxaloacetate and glutamate.
Alanine Transaminase (ALT)
- Alanine transaminase (ALT) is another example of a transaminase enzyme, with enzymatic activity similar to AST.
- ALT is predominantly found in the liver and plays a crucial role in liver function.
- Elevated ALT levels in the blood can indicate liver injury or disease, such as hepatitis or cirrhosis.
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Description
This quiz covers transamination reactions, which involve the redistribution of amino groups among amino acids. It explains the role of transaminases and the general reaction of transamination.
