18 Questions
What is the primary role of transamination in amino acid metabolism?
It facilitates the conversion of one amino acid to another by transferring an amino group.
Which of the following statements about the enzyme glutamate dehydrogenase is correct?
It is involved in the oxidative deamination of glutamate, liberating ammonia.
Which of the following statements about the role of transamination in amino acid metabolism is incorrect?
It is involved in the synthesis of essential amino acids.
Which of the following enzymes is responsible for the deamination of serine, threonine, and homoserine?
Amino acid dehydrases
What is the significance of glutamate acting as a 'collection center' for amino groups from other amino acids?
It facilitates the catabolism of amino acids by removing their amino groups.
Which of the following enzymes is responsible for the deamination of histidine?
Histidase
What is the main pathway by which the body can get rid of ammonia?
Formation of urea
Where does the urea biosynthesis occur?
Liver
What is the source of the two nitrogen atoms in urea?
Ammonia and aspartic acid
Which of the following is a source of ammonia in the body?
Transdeamination of amino acids
What is the significance of the urea cycle?
It converts highly toxic ammonia to less toxic urea
How is the ammonia formed in the kidneys used?
Regulation of acid-base balance
What is the primary function of converting ammonia to nontoxic metabolites?
To prevent the accumulation of toxic ammonia in tissues
Which form is ammonia transported in from peripheral tissues to the liver?
Both glutamine and alanine
What is the role of the enzyme glutaminase in the transport of ammonia?
It converts glutamine to glutamate and ammonia in the liver
What is the significance of the glucose-alanine cycle in the transport of ammonia?
It transports ammonia from muscles to the liver
What is the role of the enzyme glutamine synthetase in the transport of ammonia?
It converts glutamate to glutamine in peripheral tissues
What is the final fate of ammonia transported to the liver?
It is excreted as urea
Learn about the process of transamination, where the transfer of α-amino group between amino acids and keto acids occurs, resulting in the formation of new amino acids and ketoacids. Understand the significance of transamination in both amino acid synthesis and catabolism.
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