Transamination Process Overview
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Questions and Answers

What is the primary role of transamination in amino acid metabolism?

  • It is the sole mechanism for catabolism of all amino acids.
  • It is responsible for the synthesis of all essential amino acids.
  • It facilitates the conversion of one amino acid to another by transferring an amino group. (correct)
  • It is the initial step in the deamination process for all amino acids.

Which of the following statements about the enzyme glutamate dehydrogenase is correct?

  • It is responsible for the transamination of glutamate and pyruvate.
  • It is involved in the oxidative deamination of glutamate, liberating ammonia. (correct)
  • It catalyzes the non-oxidative deamination of glutamate.
  • It is a PLP-dependent enzyme involved in the deamination of serine and threonine.

Which of the following statements about the role of transamination in amino acid metabolism is incorrect?

  • It produces substrates for gluconeogenesis.
  • It is the first step in the catabolism of amino acids.
  • It is involved in the synthesis of essential amino acids. (correct)
  • It facilitates the synthesis of non-essential amino acids.

Which of the following enzymes is responsible for the deamination of serine, threonine, and homoserine?

<p>Amino acid dehydrases (A)</p> Signup and view all the answers

What is the significance of glutamate acting as a 'collection center' for amino groups from other amino acids?

<p>It facilitates the catabolism of amino acids by removing their amino groups. (A)</p> Signup and view all the answers

Which of the following enzymes is responsible for the deamination of histidine?

<p>Histidase (B)</p> Signup and view all the answers

What is the main pathway by which the body can get rid of ammonia?

<p>Formation of urea (D)</p> Signup and view all the answers

Where does the urea biosynthesis occur?

<p>Liver (A)</p> Signup and view all the answers

What is the source of the two nitrogen atoms in urea?

<p>Ammonia and aspartic acid (D)</p> Signup and view all the answers

Which of the following is a source of ammonia in the body?

<p>Transdeamination of amino acids (B)</p> Signup and view all the answers

What is the significance of the urea cycle?

<p>It converts highly toxic ammonia to less toxic urea (B)</p> Signup and view all the answers

How is the ammonia formed in the kidneys used?

<p>Regulation of acid-base balance (C)</p> Signup and view all the answers

What is the primary function of converting ammonia to nontoxic metabolites?

<p>To prevent the accumulation of toxic ammonia in tissues (B)</p> Signup and view all the answers

Which form is ammonia transported in from peripheral tissues to the liver?

<p>Both glutamine and alanine (D)</p> Signup and view all the answers

What is the role of the enzyme glutaminase in the transport of ammonia?

<p>It converts glutamine to glutamate and ammonia in the liver (D)</p> Signup and view all the answers

What is the significance of the glucose-alanine cycle in the transport of ammonia?

<p>It transports ammonia from muscles to the liver (D)</p> Signup and view all the answers

What is the role of the enzyme glutamine synthetase in the transport of ammonia?

<p>It converts glutamate to glutamine in peripheral tissues (C)</p> Signup and view all the answers

What is the final fate of ammonia transported to the liver?

<p>It is excreted as urea (B)</p> Signup and view all the answers

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