Transamination Process Overview
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Questions and Answers

What is the primary role of transamination in amino acid metabolism?

  • It is the sole mechanism for catabolism of all amino acids.
  • It is responsible for the synthesis of all essential amino acids.
  • It facilitates the conversion of one amino acid to another by transferring an amino group. (correct)
  • It is the initial step in the deamination process for all amino acids.

    • Which of the following statements about the enzyme glutamate dehydrogenase is correct?

  • It is responsible for the transamination of glutamate and pyruvate.
  • It is involved in the oxidative deamination of glutamate, liberating ammonia. (correct)
  • It catalyzes the non-oxidative deamination of glutamate.
  • It is a PLP-dependent enzyme involved in the deamination of serine and threonine.

    • Which of the following statements about the role of transamination in amino acid metabolism is incorrect?

  • It produces substrates for gluconeogenesis.
  • It is the first step in the catabolism of amino acids.
  • It is involved in the synthesis of essential amino acids. (correct)
  • It facilitates the synthesis of non-essential amino acids.

    • Which of the following enzymes is responsible for the deamination of serine, threonine, and homoserine?

    <p>Amino acid dehydrases</p> Signup and view all the answers

    What is the significance of glutamate acting as a 'collection center' for amino groups from other amino acids?

    <p>It facilitates the catabolism of amino acids by removing their amino groups.</p> Signup and view all the answers

    Which of the following enzymes is responsible for the deamination of histidine?

    <p>Histidase</p> Signup and view all the answers

    What is the main pathway by which the body can get rid of ammonia?

    <p>Formation of urea</p> Signup and view all the answers

    Where does the urea biosynthesis occur?

    <p>Liver</p> Signup and view all the answers

    What is the source of the two nitrogen atoms in urea?

    <p>Ammonia and aspartic acid</p> Signup and view all the answers

    Which of the following is a source of ammonia in the body?

    <p>Transdeamination of amino acids</p> Signup and view all the answers

    What is the significance of the urea cycle?

    <p>It converts highly toxic ammonia to less toxic urea</p> Signup and view all the answers

    How is the ammonia formed in the kidneys used?

    <p>Regulation of acid-base balance</p> Signup and view all the answers

    What is the primary function of converting ammonia to nontoxic metabolites?

    <p>To prevent the accumulation of toxic ammonia in tissues</p> Signup and view all the answers

    Which form is ammonia transported in from peripheral tissues to the liver?

    <p>Both glutamine and alanine</p> Signup and view all the answers

    What is the role of the enzyme glutaminase in the transport of ammonia?

    <p>It converts glutamine to glutamate and ammonia in the liver</p> Signup and view all the answers

    What is the significance of the glucose-alanine cycle in the transport of ammonia?

    <p>It transports ammonia from muscles to the liver</p> Signup and view all the answers

    What is the role of the enzyme glutamine synthetase in the transport of ammonia?

    <p>It converts glutamate to glutamine in peripheral tissues</p> Signup and view all the answers

    What is the final fate of ammonia transported to the liver?

    <p>It is excreted as urea</p> Signup and view all the answers

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