Toxicology Overview Quiz
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Questions and Answers

What is Siderosis primarily caused by?

  • Inhalation of cotton dust
  • Exposure to high noise levels
  • Inhalation of metal fumes (correct)
  • Age-related changes
  • Which biosafety level involves the highest potential hazards?

  • Level 2
  • Level 1
  • Level 4 (correct)
  • Level 3
  • What is the primary function of a Local Exhaust Ventilation (LEV) system?

  • Mix contaminated air with fresh air
  • Increase overall ventilation flow
  • Remove contaminated air at the source (correct)
  • Supply fresh air to an area
  • What is the standard permissible noise level according to OSHA for 8 hours?

    <p>90 dBA (B)</p> Signup and view all the answers

    What is the first step in adding noise levels together?

    <p>Arrange in ascending order (A)</p> Signup and view all the answers

    Which class of biosafety cabinets offers maximum protection?

    <p>Class 3 (C)</p> Signup and view all the answers

    What is the primary consideration for LEV's recommendation?

    <p>High generation of contaminants (B)</p> Signup and view all the answers

    What is defined as any unwanted sound?

    <p>Noise (A)</p> Signup and view all the answers

    How is noise dosage for a worker calculated?

    <p>By summing exposure over time (C)</p> Signup and view all the answers

    What is the effective noise level of 80 dBA combined with 85 dBA after applying the noise thump rule?

    <p>84 dBA (B)</p> Signup and view all the answers

    What is the permissible exposure time for a worker exposed to 100 dBA?

    <p>30 minutes (B)</p> Signup and view all the answers

    Which type of radiation is least penetrative?

    <p>Alpha rays (D)</p> Signup and view all the answers

    What is the allowable exposure time at an 8 hr shift for noise levels at 93 dBA?

    <p>5.2 hours (B)</p> Signup and view all the answers

    What is the highest sound level at which OSHA requires a hearing conservation program?

    <p>85 dBA (D)</p> Signup and view all the answers

    Which of the following statements is true regarding beta particles?

    <p>More penetrative than alpha rays (B)</p> Signup and view all the answers

    Which equation is used to calculate the unknown sound level at a second location?

    <p>dB1 = dB0 + 20 Log10 (d0/d1) (D)</p> Signup and view all the answers

    What type of radiation can damage DNA?

    <p>Gamma rays (A)</p> Signup and view all the answers

    Which equipment is commonly used to measure radiation?

    <p>Geiger counter (A)</p> Signup and view all the answers

    What does STS stand for in hearing conservation programs?

    <p>Standard Threshold Shift (D)</p> Signup and view all the answers

    What is the threshold for a dose that necessitates the reporting of STS?

    <p>10 dBA (A)</p> Signup and view all the answers

    What is the primary route of entry for toxic substances that involves the respiratory system?

    <p>Inhalation (A)</p> Signup and view all the answers

    Which of the following substances is classified as a hepatotoxin?

    <p>Carbon Tetrachloride (C)</p> Signup and view all the answers

    What does the term 'Lethal Dose (LD 50)' refer to?

    <p>Dosage that can produce death in 50% of test animals (A)</p> Signup and view all the answers

    Which of the following represents a route of entry that involves skin puncture?

    <p>Injection (D)</p> Signup and view all the answers

    Which type of toxin is known to cause permanent changes to DNA?

    <p>Mutagens (C)</p> Signup and view all the answers

    Brucellosis is primarily transmitted through which of the following?

    <p>Cattles and unpasteurized milk (A)</p> Signup and view all the answers

    Which of the following is a characteristic of chronic toxicity?

    <p>Repeated long-term exposure (A)</p> Signup and view all the answers

    What do neurotoxins specifically affect?

    <p>Nervous System (C)</p> Signup and view all the answers

    What is the primary reservoir of Q fever?

    <p>Cattle, sheep, and goats (B)</p> Signup and view all the answers

    Which chemical is classified as an ototoxin?

    <p>Styrene (A)</p> Signup and view all the answers

    Flashcards

    What is a toxic substance?

    Substances causing harm to normal human physiological function.

    Acute Toxicity

    Toxicity occurring over a short period.

    Chronic Toxicity

    Toxicity occurring over a long period due to repeated exposure.

    Dosage

    Amount of chemical per body weight.

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    Lethal Dose (LD 50)

    Dosage killing 50% of test animals. Unit: mg/kg.

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    Lethal Concentration (LC 50)

    Concentration in air killing 50% of test animals. Unit: PPM or mg/m3.

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    Hepatotoxins

    Chemicals damaging the liver.

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    Neurotoxins

    Chemicals damaging the nervous system.

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    Mutagens

    Chemicals causing permanent DNA changes.

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    Teratogens

    Chemicals damaging a developing fetus.

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    Siderosis

    Inhalation of metal fumes, for example, magnesium and zinc during welding.

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    Byssinosis

    Inhalation of cotton dust leading to lung issues.

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    Presbycusis

    Age-related hearing loss.

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    Biosafety Levels

    A system classifying biological agents based on their risk levels.

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    Biosafety Cabinets

    Enclosed workstations designed to protect workers and the environment from hazardous materials.

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    Dilution Ventilation

    A type of ventilation where fresh air is mixed with contaminated air to reduce the concentration of contaminants below the Occupational Exposure Limit (OEL).

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    Local Exhaust Ventilation (LEV)

    A type of ventilation that removes contaminated air directly from the source of generation.

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    Air Changes Per Hour

    A measure of the number of times the air in a space is completely replaced with fresh air per hour.

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    Noise

    Any unwanted sound.

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    Decibels (dBA)

    A logarithmic scale used to measure the intensity of sound, with higher decibels representing louder sounds.

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    Permissible Noise Exposure Time

    The time a worker is allowed to be exposed to a specific noise level without exceeding OSHA limits. This is based on the inverse square law, where noise intensity decreases with increasing distance from the source.

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    Sound Attenuation - Inverse Square Law

    A formula used to calculate the decrease in sound pressure level as the distance from the noise source increases. It's based on the inverse square law.

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    Outer Ear

    The outer ear's primary function is to gather sound waves and channel them towards the middle ear. It acts as a funnel for sound.

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    Middle Ear

    The middle ear amplifies sound vibrations using tiny bones called ossicles. This allows for efficient transmission to the inner ear.

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    Inner Ear

    The inner ear is responsible for converting sound vibrations into electrical signals, which are sent to the brain for interpretation. This is where we actually hear sounds.

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    OSHA's Hearing Conservation Program

    A program mandated by OSHA to protect workers from hearing damage due to prolonged exposure to excessive noise levels.

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    Standard Threshold Shift (STS)

    A change in hearing threshold measured by comparing an audiogram taken after noise exposure to a baseline audiogram. It indicates hearing loss.

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    Radiation

    Energy or particles traveling through space or a medium. It can be classified as ionizing or non-ionizing, depending on its ability to cause ionization in matter.

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    Ionizing Radiation

    Radiation that has enough energy to remove electrons from atoms, creating ions. Ionizing radiation can damage living tissue.

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    Non-ionizing Radiation

    Radiation that does not have enough energy to create ions in matter. It's generally less harmful than ionizing radiation but can still have biological effects.

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    Study Notes

    Toxicology

    • Toxic substances negatively affect normal human physiological functions. Examples include lead, mercury, alcohol, and hexavalent chromium.
    • Acute toxicity involves a relatively short time frame.
    • Chronic toxicity results from repeated exposure over a long period.
    • Routes of entry include ingestion (eating/drinking), inhalation (breathing), skin absorption, and injection (through cuts/punctures).

    Dosage

    • Dosage is the amount of a chemical administered per unit of body weight.
    • Lethal Dose (LD50) is the dosage of a toxic chemical that causes death in 50% of test animals. The unit is mg/kg.
    • Lethal Concentration (LC50) is the concentration of a toxic chemical in air that kills 50% of test animals. The unit is ppm or mg/m³. Route of entry is inhalation.

    Target Organ Chemicals

    • Hepatotoxins affect the liver. Carbon tetrachloride is an example.
    • Neurotoxins affect the nervous system. Lead is an example.

    Reproductive Toxins

    • Mutagens cause permanent changes to DNA. Radioactive materials and benzene are examples.
    • Teratogens harm a developing fetus, and effects cannot be passed to future generations. Examples include nicotine and alcohol.
    • Ototoxins affect hearing and balance. Styrene and antibiotics are examples.

    Biological Hazards

    • Biological hazards include infections (viral or bacterial).
    • Symptoms, transmission methods (e.g., animal contact), and affected organs (e.g., CNS, lungs) are factors.
    • Common biological hazards include Brucellosis, Leptospirosis, Tuberculosis, Hepatitis A/B, Q fever.

    Biosafety Levels

    • Biosafety levels are categorized for potential hazards.
    • Levels range from minimal to high. COVID-19 is at Level 4, Class 3.

    Ventilation

    • Ventilation types include dilution and local exhaust.
    • Dilution ventilation mixes contaminated air with fresh air, while local exhaust removes contaminated air directly from the source.
    • Hood design is a critical component of Local Exhaust Ventilation (LEV).

    Noise

    • Noise is any unwanted sound.
    • Noise levels are measured in decibels (dB).
    • OSHA guidelines exist regarding noise exposure for 8 hours in specific decibel levels.
    • Noise addition rules allow combining noise levels with a specified formula or rules.

    Radiation and Dosage Calculation

    • Radiation is energy from a source that travels through space.
    • Ionizing radiation affects matter, while non-ionizing radiation does not. (Alpha, Beta, Gamma)
    • Radiation exposure is measured in units such as curies, becquerels, roentgens and Sieverts.
    • Radiation exposure is calculated using inverse square law, or formulas for dosage, considering time exposure in specific decibel levels.
    • Exposure standards exist for worker safety.
    • The Nuclear Regulatory Commission (NRC) regulates radioactive material exposure.

    Control Measures

    • Duration, Distance, and Shielding are used to minimize exposure to radiation risks.

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    Description

    Test your knowledge on toxic substances and their effects on human health. This quiz covers acute and chronic toxicity, dosage calculations, and target organ chemicals. Gain a deeper understanding of how toxic agents interact with the body and their potential hazards.

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