Toxicology and Epidemiology Quiz
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Questions and Answers

What condition is characterized by dizziness, hearing loss, and tinnitus?

  • Meniere's disease (correct)
  • Siderosis
  • Toxicity
  • Bacterial infection
  • What do Threshold Limit Values (TLVs) represent?

  • Conditions safe for nearly all workers over a lifetime (correct)
  • Maximum allowable concentration of toxins in the environment
  • Guidelines for non-governmental organizations
  • The legal limits for exposure to airborne substances
  • Which of the following is true about antibodies?

  • They are proteins produced in response to antigens. (correct)
  • They are produced by all cells in the body.
  • They are a type of enzyme that breaks down foreign substances.
  • They have a cell wall structure.
  • What is a primary concern regarding physical hazards in the workplace?

    <p>They may have immediate or cumulative health effects. (A)</p> Signup and view all the answers

    Which statement correctly describes a virus?

    <p>It is a sub-microscopic infectious agent that requires a host to reproduce. (A)</p> Signup and view all the answers

    What is the term used for the immediate, noticeable response of the body to exposure to hazardous substances?

    <p>Acute effects (D)</p> Signup and view all the answers

    Which of the following describes the route of entry for a substance that is inhaled?

    <p>Enters through the nose or mouth into the alveoli (C)</p> Signup and view all the answers

    What is the effect called when damage occurs at a site other than where a hazardous substance was initially contacted?

    <p>Systemic effects (C)</p> Signup and view all the answers

    What does the latency period refer to in toxicological studies?

    <p>The time between exposure and the first sign of disease (A)</p> Signup and view all the answers

    Atopic dermatitis is commonly known as what condition?

    <p>Eczema (C)</p> Signup and view all the answers

    What is the primary reason substances can enter the body through absorption?

    <p>The presence of lacerations or abrasions increases permeability (D)</p> Signup and view all the answers

    Which layer of skin is NOT part of the main structure in the absorption process?

    <p>Subcutaneous fat (B)</p> Signup and view all the answers

    What is the purpose of blast gates in duct systems?

    <p>To balance airflow in ducts of different sizes (B)</p> Signup and view all the answers

    Which of the following is a qualitative method for measuring local exhaust ventilation (LEV)?

    <p>Visual inspection (A)</p> Signup and view all the answers

    What does a Reynolds number greater than 4000 indicate in fluid dynamics?

    <p>Fully turbulent flow (D)</p> Signup and view all the answers

    Which of the following statements is true regarding isokinetic sampling?

    <p>It ensures particles are collected at the same velocity as the air stream. (D)</p> Signup and view all the answers

    What is the role of an electrostatic precipitator?

    <p>To charge particles and collect them on oppositely charged plates (B)</p> Signup and view all the answers

    Which type of sampling pump would you use to collect respirable airborne particulate matter?

    <p>A pump equipped with a cyclone (A)</p> Signup and view all the answers

    What efficiency equation represents the effectiveness of an electrostatic precipitator?

    <p>Efficiency = (Mass removed / Mass entering) x 100 (C)</p> Signup and view all the answers

    Which of the following is an example of a psychosomatic response in the workplace?

    <p>Feeling sick due to job stress (C)</p> Signup and view all the answers

    What is a significant drawback of baghouses in air pollution control?

    <p>They require frequent cleaning to maintain pressure. (D)</p> Signup and view all the answers

    What is the molar concentration of a substance if its mole is calculated as 0.43 for a volume of 0.5 liters?

    <p>0.87 mol/l (D)</p> Signup and view all the answers

    What is the significance of a combined PPM of 0.9 for a gas mixture containing acetone and MEK?

    <p>It is below the acceptable limit. (B)</p> Signup and view all the answers

    During which seasons are Vibrio parahaemolyticus infections most likely to occur?

    <p>Summer and Fall (D)</p> Signup and view all the answers

    In which type of symbiotic relationship does one species benefit while the other is neither helped nor harmed?

    <p>Commensalism (B)</p> Signup and view all the answers

    What is the purpose of a chemical hygiene plan in a laboratory setting?

    <p>To protect workers from hazardous chemicals. (A)</p> Signup and view all the answers

    What safety measure should be taken when handling contaminated sharps?

    <p>Dispose of without bending or recapping. (B)</p> Signup and view all the answers

    What does biological monitoring assess in terms of toxic substances?

    <p>Absorption levels in body systems. (C)</p> Signup and view all the answers

    What does carburizing refer to in terms of materials treatment?

    <p>Hardening through carbon absorption. (D)</p> Signup and view all the answers

    What is a primary characteristic of Vibrio bacteria?

    <p>It is oxidase positive. (C)</p> Signup and view all the answers

    Which type of biological monitoring results are excluded from assessing toxic substances?

    <p>Results that evaluate biological effects. (B)</p> Signup and view all the answers

    What type of sampler is used to collect airborne particulate matter?

    <p>Sampling pump with an impactor (A)</p> Signup and view all the answers

    Which device is utilized to measure semi-volatile air concentrations?

    <p>Denuder (C)</p> Signup and view all the answers

    What is the primary function of a PID in air sampling?

    <p>To ionize molecules using ultraviolet light (A)</p> Signup and view all the answers

    Which method provides real-time results for measuring air quality?

    <p>Photometer (A)</p> Signup and view all the answers

    What is the primary purpose of using a charcoal tube in air sampling?

    <p>To absorb gases and vapors (B)</p> Signup and view all the answers

    What is essential for maintaining the integrity of water samples received by the lab?

    <p>Proper logging and chain of custody assurance (C)</p> Signup and view all the answers

    Which sampler is primarily used for collecting volatile organic compounds (VOCs)?

    <p>Sampling pump with a charcoal tube (B)</p> Signup and view all the answers

    What is the role of analytical sensitivity in air sampling?

    <p>To decide the required sample volume (B)</p> Signup and view all the answers

    Which device would typically be used throughout the day to sample carbon monoxide (CO) from an individual's breathing zone?

    <p>Detector tube (D)</p> Signup and view all the answers

    How are results from the use of an impinger typically provided?

    <p>After analysis in the lab (B)</p> Signup and view all the answers

    Flashcards

    Absorption

    The process by which a substance enters the body and reaches the bloodstream.

    Local effects

    Harmful effects occurring at the point of contact with a substance, such as burns or irritation.

    Systemic effects

    Harmful effects occurring in a part of the body distant from the point of contact, such as organ damage.

    Target organ

    The organ or tissue that is primarily affected by a substance.

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    Acute effects

    Immediate and obvious responses to exposure to a substance, usually reversible.

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    Chronic effects

    Effects that appear a long time after exposure and can be irreversible.

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    Latency period

    The time period between exposure to a substance and the first symptoms of disease.

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    Blast gate

    A device used to control airflow in ducts of different sizes by balancing the air pressure.

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    Reynold's Number

    The study of how air and fluids flow, particularly about the transition between laminar and turbulent flows.

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    MCE filter

    Airborne particulate matter is collected by a pump with an MCE filter, allowing for analysis of the overall particulate matter.

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    Cyclone

    Airborne particulate matter specifically smaller than 4 microns is collected by a pump with a cyclone, focusing on respirable particles.

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    Isokinetic Sampling

    A method of air sampling where the velocity of the air in the sampling nozzle matches the velocity of the air stream.

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    Psychosomatic Syndrome

    A psychological condition often mistaken for a physical ailment, triggered by stress and often related to indoor air quality (IAQ).

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    Baghouse

    An air pollution control device that captures dust and particulate matter less than 0.25 microns.

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    Electrostatic Precipitator

    A technique used to collect particles in a moving stream by charging particles with a positive or negative charge, then collecting them on oppositely charged plates.

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    Multiple Chemical Sensitivity

    A condition where individuals experience sensitivity or intolerance to extremely low levels of common chemicals.

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    Impactor

    A device used to collect airborne particulate matter by forcing air through a series of stages.

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    Charcoal Tube Sampling

    A sampling method used to collect gases and vapors by adsorbing them onto activated charcoal.

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    Photoionization Detector (PID)

    A device that measures the concentration of airborne particles in real-time using ultraviolet light to ionize molecules.

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    Photometer

    A device used to measure particle concentrations in the air, providing real-time results.

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    Denuder

    A device used to measure concentrations of semi-volatile compounds in air, requiring laboratory analysis.

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    Impinger

    A device used to collect and measure a variety of airborne contaminants, requiring laboratory analysis.

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    Analytical Sensitivity

    The minimum amount of a substance that can be detected by an analytical method.

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    Ecolyzer

    A device used to measure carbon monoxide (CO) concentrations in the air.

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    Detector Tube

    An instrument used to measure multiple parameters, often used in occupational settings.

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    Chain of Custody

    A process used to ensure the proper handling and tracking of samples throughout their lifecycle.

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    Mutualism

    A symbiotic relationship where both species benefit.

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    Commensalism

    A symbiotic relationship where one species benefits and the other is unaffected.

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    Parasitism

    A symbiotic relationship where one species (the parasite) benefits while the other species (the host) is harmed.

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    Vibrio parahaemolyticus

    A bacteria commonly found in seawater, often causing gastroenteritis after consuming undercooked seafood.

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    Carburizing

    A heat treatment process that hardens metal by absorbing carbon monoxide (CO) at high temperatures.

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    Chemical Hygiene Plan

    A plan designed to protect laboratory workers from hazardous chemicals.

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    Employee Exposure Monitoring

    The act of monitoring or measuring the exposure of workers to toxic substances or harmful physical agents.

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    Biological Monitoring

    The measurement of a toxic substance or harmful physical agent in a worker's body, such as blood, urine, or breath.

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    Molar Concentration

    The concentration of a substance in a solution, measured in moles per liter (mol/L).

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    Mole

    A measure of the amount of a substance, equivalent to its molecular weight in grams.

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    Antibodies

    A type of protein made by certain white blood cells in response to a foreign substance (antigen).

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    Siderosis

    Is a lung disease caused by inhalation of FeO or another metallic particle.

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    Toxicity

    The effects of exposure to a substance depend on factors like the dose, rate of exposure, substance's physical state, temperature, absorption site, diet, and overall health.

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    Permissible Exposure Limits (PEL)

    Legal exposure limits to airborne substances in the US established by OSHA, often based on NIOSH TLVs.

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    Virus

    A sub-microscopic infectious agent incapable of growing or reproducing outside a host cell, containing nucleic acid, capsid, envelope, but NOT a cell wall.

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    Study Notes

    Toxicology- Epidemiology

    • Routes of Entry: Inhalation, ingestion, and absorption. Substances enter the body via the digestive system (ingestion), the lungs (inhalation), or through the skin (absorption).
    • Ingestion: Substances are swallowed and enter the digestive system.
    • Absorption: Substances can enter the bloodstream through the skin, especially with lacerations or abrasions.
    • Inhalation: Air enters the body via nose or mouth reaching the alveoli.
    • Local effects: Damage occurs at the site of contact with a substance (e.g., a burn).
    • Systemic effects: Damage occurs at a different target organ other than the point of contact (e.g., lead fumes on the brain).
    • Acute effects: Immediate and obvious reactions (e.g., headache, nausea). These are generally reversible.
    • Chronic effects: Reactions that occur over a long period (e.g., 20-30 years), and are often irreversible.
    • Latency period: The time between exposure and the first sign of disease.
    • Atopic dermatitis: A skin condition characterized by inflammation and tendency to run in families.
    • Contact dermatitis: Inflammation of the skin caused by irritants or allergens.

    Immunisation

    • Immunisation: A process of introducing a weakened form of a disease causing bacteria to a person to build up immunity to the disease.

    LC50 and LD50

    • LC50: The inhaled concentration sufficient to kill 50% of a test population in a fixed time period (usually 4 hours). Usually ml/Kg or mg/L.
    • LD50: The administered oral or dermal dose to a test population that is sufficient to cause death in 50% of the population. Usually in mg/Kg

    Dust types

    • Inhalable dust: Particle size >100 μm.
    • Thoracic dust: Particle size <100 μm.
    • Respirable dust: Particle size <10 μm, able to reach the lower parts of the lungs during normal breathing.
    • NOAEL (No Observed Adverse Effect Level): The highest observed point on the exposure response curve where there was no adverse health effect observed.
    • LOAEL (Lowest Observed Adverse Effect Level): The lowest observed point on the exposure response curve where some adverse effect is noted.

    Other

    • Additive Effect: The combined effect of chemicals is equal to the sum of each chemical acting independently (e.g., 2 + 2 = 4).

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    Description

    Test your knowledge on the routes of entry of toxic substances, their local and systemic effects, and the differences between acute and chronic responses. This quiz covers essential concepts in toxicology and the impact on human health. Ideal for students and professionals in environmental health and safety.

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