Toxicology and Epidemiology Quiz

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Questions and Answers

What condition is characterized by dizziness, hearing loss, and tinnitus?

  • Meniere's disease (correct)
  • Siderosis
  • Toxicity
  • Bacterial infection

What do Threshold Limit Values (TLVs) represent?

  • Conditions safe for nearly all workers over a lifetime (correct)
  • Maximum allowable concentration of toxins in the environment
  • Guidelines for non-governmental organizations
  • The legal limits for exposure to airborne substances

Which of the following is true about antibodies?

  • They are proteins produced in response to antigens. (correct)
  • They are produced by all cells in the body.
  • They are a type of enzyme that breaks down foreign substances.
  • They have a cell wall structure.

What is a primary concern regarding physical hazards in the workplace?

<p>They may have immediate or cumulative health effects. (A)</p> Signup and view all the answers

Which statement correctly describes a virus?

<p>It is a sub-microscopic infectious agent that requires a host to reproduce. (A)</p> Signup and view all the answers

What is the term used for the immediate, noticeable response of the body to exposure to hazardous substances?

<p>Acute effects (D)</p> Signup and view all the answers

Which of the following describes the route of entry for a substance that is inhaled?

<p>Enters through the nose or mouth into the alveoli (C)</p> Signup and view all the answers

What is the effect called when damage occurs at a site other than where a hazardous substance was initially contacted?

<p>Systemic effects (C)</p> Signup and view all the answers

What does the latency period refer to in toxicological studies?

<p>The time between exposure and the first sign of disease (A)</p> Signup and view all the answers

Atopic dermatitis is commonly known as what condition?

<p>Eczema (C)</p> Signup and view all the answers

What is the primary reason substances can enter the body through absorption?

<p>The presence of lacerations or abrasions increases permeability (D)</p> Signup and view all the answers

Which layer of skin is NOT part of the main structure in the absorption process?

<p>Subcutaneous fat (B)</p> Signup and view all the answers

What is the purpose of blast gates in duct systems?

<p>To balance airflow in ducts of different sizes (B)</p> Signup and view all the answers

Which of the following is a qualitative method for measuring local exhaust ventilation (LEV)?

<p>Visual inspection (A)</p> Signup and view all the answers

What does a Reynolds number greater than 4000 indicate in fluid dynamics?

<p>Fully turbulent flow (D)</p> Signup and view all the answers

Which of the following statements is true regarding isokinetic sampling?

<p>It ensures particles are collected at the same velocity as the air stream. (D)</p> Signup and view all the answers

What is the role of an electrostatic precipitator?

<p>To charge particles and collect them on oppositely charged plates (B)</p> Signup and view all the answers

Which type of sampling pump would you use to collect respirable airborne particulate matter?

<p>A pump equipped with a cyclone (A)</p> Signup and view all the answers

What efficiency equation represents the effectiveness of an electrostatic precipitator?

<p>Efficiency = (Mass removed / Mass entering) x 100 (C)</p> Signup and view all the answers

Which of the following is an example of a psychosomatic response in the workplace?

<p>Feeling sick due to job stress (C)</p> Signup and view all the answers

What is a significant drawback of baghouses in air pollution control?

<p>They require frequent cleaning to maintain pressure. (D)</p> Signup and view all the answers

What is the molar concentration of a substance if its mole is calculated as 0.43 for a volume of 0.5 liters?

<p>0.87 mol/l (D)</p> Signup and view all the answers

What is the significance of a combined PPM of 0.9 for a gas mixture containing acetone and MEK?

<p>It is below the acceptable limit. (B)</p> Signup and view all the answers

During which seasons are Vibrio parahaemolyticus infections most likely to occur?

<p>Summer and Fall (D)</p> Signup and view all the answers

In which type of symbiotic relationship does one species benefit while the other is neither helped nor harmed?

<p>Commensalism (B)</p> Signup and view all the answers

What is the purpose of a chemical hygiene plan in a laboratory setting?

<p>To protect workers from hazardous chemicals. (A)</p> Signup and view all the answers

What safety measure should be taken when handling contaminated sharps?

<p>Dispose of without bending or recapping. (B)</p> Signup and view all the answers

What does biological monitoring assess in terms of toxic substances?

<p>Absorption levels in body systems. (C)</p> Signup and view all the answers

What does carburizing refer to in terms of materials treatment?

<p>Hardening through carbon absorption. (D)</p> Signup and view all the answers

What is a primary characteristic of Vibrio bacteria?

<p>It is oxidase positive. (C)</p> Signup and view all the answers

Which type of biological monitoring results are excluded from assessing toxic substances?

<p>Results that evaluate biological effects. (B)</p> Signup and view all the answers

What type of sampler is used to collect airborne particulate matter?

<p>Sampling pump with an impactor (A)</p> Signup and view all the answers

Which device is utilized to measure semi-volatile air concentrations?

<p>Denuder (C)</p> Signup and view all the answers

What is the primary function of a PID in air sampling?

<p>To ionize molecules using ultraviolet light (A)</p> Signup and view all the answers

Which method provides real-time results for measuring air quality?

<p>Photometer (A)</p> Signup and view all the answers

What is the primary purpose of using a charcoal tube in air sampling?

<p>To absorb gases and vapors (B)</p> Signup and view all the answers

What is essential for maintaining the integrity of water samples received by the lab?

<p>Proper logging and chain of custody assurance (C)</p> Signup and view all the answers

Which sampler is primarily used for collecting volatile organic compounds (VOCs)?

<p>Sampling pump with a charcoal tube (B)</p> Signup and view all the answers

What is the role of analytical sensitivity in air sampling?

<p>To decide the required sample volume (B)</p> Signup and view all the answers

Which device would typically be used throughout the day to sample carbon monoxide (CO) from an individual's breathing zone?

<p>Detector tube (D)</p> Signup and view all the answers

How are results from the use of an impinger typically provided?

<p>After analysis in the lab (B)</p> Signup and view all the answers

Flashcards

Absorption

The process by which a substance enters the body and reaches the bloodstream.

Local effects

Harmful effects occurring at the point of contact with a substance, such as burns or irritation.

Systemic effects

Harmful effects occurring in a part of the body distant from the point of contact, such as organ damage.

Target organ

The organ or tissue that is primarily affected by a substance.

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Acute effects

Immediate and obvious responses to exposure to a substance, usually reversible.

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Chronic effects

Effects that appear a long time after exposure and can be irreversible.

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Latency period

The time period between exposure to a substance and the first symptoms of disease.

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Blast gate

A device used to control airflow in ducts of different sizes by balancing the air pressure.

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Reynold's Number

The study of how air and fluids flow, particularly about the transition between laminar and turbulent flows.

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MCE filter

Airborne particulate matter is collected by a pump with an MCE filter, allowing for analysis of the overall particulate matter.

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Cyclone

Airborne particulate matter specifically smaller than 4 microns is collected by a pump with a cyclone, focusing on respirable particles.

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Isokinetic Sampling

A method of air sampling where the velocity of the air in the sampling nozzle matches the velocity of the air stream.

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Psychosomatic Syndrome

A psychological condition often mistaken for a physical ailment, triggered by stress and often related to indoor air quality (IAQ).

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Baghouse

An air pollution control device that captures dust and particulate matter less than 0.25 microns.

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Electrostatic Precipitator

A technique used to collect particles in a moving stream by charging particles with a positive or negative charge, then collecting them on oppositely charged plates.

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Multiple Chemical Sensitivity

A condition where individuals experience sensitivity or intolerance to extremely low levels of common chemicals.

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Impactor

A device used to collect airborne particulate matter by forcing air through a series of stages.

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Charcoal Tube Sampling

A sampling method used to collect gases and vapors by adsorbing them onto activated charcoal.

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Photoionization Detector (PID)

A device that measures the concentration of airborne particles in real-time using ultraviolet light to ionize molecules.

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Photometer

A device used to measure particle concentrations in the air, providing real-time results.

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Denuder

A device used to measure concentrations of semi-volatile compounds in air, requiring laboratory analysis.

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Impinger

A device used to collect and measure a variety of airborne contaminants, requiring laboratory analysis.

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Analytical Sensitivity

The minimum amount of a substance that can be detected by an analytical method.

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Ecolyzer

A device used to measure carbon monoxide (CO) concentrations in the air.

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Detector Tube

An instrument used to measure multiple parameters, often used in occupational settings.

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Chain of Custody

A process used to ensure the proper handling and tracking of samples throughout their lifecycle.

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Mutualism

A symbiotic relationship where both species benefit.

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Commensalism

A symbiotic relationship where one species benefits and the other is unaffected.

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Parasitism

A symbiotic relationship where one species (the parasite) benefits while the other species (the host) is harmed.

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Vibrio parahaemolyticus

A bacteria commonly found in seawater, often causing gastroenteritis after consuming undercooked seafood.

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Carburizing

A heat treatment process that hardens metal by absorbing carbon monoxide (CO) at high temperatures.

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Chemical Hygiene Plan

A plan designed to protect laboratory workers from hazardous chemicals.

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Employee Exposure Monitoring

The act of monitoring or measuring the exposure of workers to toxic substances or harmful physical agents.

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Biological Monitoring

The measurement of a toxic substance or harmful physical agent in a worker's body, such as blood, urine, or breath.

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Molar Concentration

The concentration of a substance in a solution, measured in moles per liter (mol/L).

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Mole

A measure of the amount of a substance, equivalent to its molecular weight in grams.

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Antibodies

A type of protein made by certain white blood cells in response to a foreign substance (antigen).

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Siderosis

Is a lung disease caused by inhalation of FeO or another metallic particle.

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Toxicity

The effects of exposure to a substance depend on factors like the dose, rate of exposure, substance's physical state, temperature, absorption site, diet, and overall health.

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Permissible Exposure Limits (PEL)

Legal exposure limits to airborne substances in the US established by OSHA, often based on NIOSH TLVs.

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Virus

A sub-microscopic infectious agent incapable of growing or reproducing outside a host cell, containing nucleic acid, capsid, envelope, but NOT a cell wall.

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Study Notes

Toxicology- Epidemiology

  • Routes of Entry: Inhalation, ingestion, and absorption. Substances enter the body via the digestive system (ingestion), the lungs (inhalation), or through the skin (absorption).
  • Ingestion: Substances are swallowed and enter the digestive system.
  • Absorption: Substances can enter the bloodstream through the skin, especially with lacerations or abrasions.
  • Inhalation: Air enters the body via nose or mouth reaching the alveoli.
  • Local effects: Damage occurs at the site of contact with a substance (e.g., a burn).
  • Systemic effects: Damage occurs at a different target organ other than the point of contact (e.g., lead fumes on the brain).
  • Acute effects: Immediate and obvious reactions (e.g., headache, nausea). These are generally reversible.
  • Chronic effects: Reactions that occur over a long period (e.g., 20-30 years), and are often irreversible.
  • Latency period: The time between exposure and the first sign of disease.
  • Atopic dermatitis: A skin condition characterized by inflammation and tendency to run in families.
  • Contact dermatitis: Inflammation of the skin caused by irritants or allergens.

Immunisation

  • Immunisation: A process of introducing a weakened form of a disease causing bacteria to a person to build up immunity to the disease.

LC50 and LD50

  • LC50: The inhaled concentration sufficient to kill 50% of a test population in a fixed time period (usually 4 hours). Usually ml/Kg or mg/L.
  • LD50: The administered oral or dermal dose to a test population that is sufficient to cause death in 50% of the population. Usually in mg/Kg

Dust types

  • Inhalable dust: Particle size >100 μm.
  • Thoracic dust: Particle size <100 μm.
  • Respirable dust: Particle size <10 μm, able to reach the lower parts of the lungs during normal breathing.
  • NOAEL (No Observed Adverse Effect Level): The highest observed point on the exposure response curve where there was no adverse health effect observed.
  • LOAEL (Lowest Observed Adverse Effect Level): The lowest observed point on the exposure response curve where some adverse effect is noted.

Other

  • Additive Effect: The combined effect of chemicals is equal to the sum of each chemical acting independently (e.g., 2 + 2 = 4).

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